4Z5T

The nucleosome containing human H3.5

Summary for 4Z5T

• Entry DOI: 10.2210/pdb4z5t/pdb
• Descriptor: Histone H3.3C, Histone H4, Histone H2A type 1-B/E, ... (5 entities in total)
• Functional Keywords: histone fold, dna binding, nucleus, spermatogenesis, structural protein-dna complex, structural protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 201845.95

Authors

Urahama, T.,Harada, A.,Maehara, K.,Horikoshi, N.,Sato, K.,Sato, Y.,Shiraishi, K.,Sugino, N.,Osakabe, A.,Tachiwana, H.,Kagawa, W.,Kimura, H.,Ohkawa, Y.,Kurumizaka, H. (deposition date: 2015-04-03, release date: 2016-02-10, Last modification date: 2023-11-08)

Primary citation

Urahama, T.,Harada, A.,Maehara, K.,Horikoshi, N.,Sato, K.,Sato, Y.,Shiraishi, K.,Sugino, N.,Osakabe, A.,Tachiwana, H.,Kagawa, W.,Kimura, H.,Ohkawa, Y.,Kurumizaka, H.
Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis.
Epigenetics Chromatin, 9:2-2, 2016

PubMed Abstract: Human histone H3.5 is a non-allelic H3 variant evolutionally derived from H3.3. The H3.5 mRNA is highly expressed in human testis. However, the function of H3.5 has remained poorly understood.

PubMed: 26779285
DOI: 10.1186/s13072-016-0051-y

Experimental method

X-RAY DIFFRACTION (2.8 Å)