6TRO

Crystal structure of the T-cell receptor GVY01 bound to HLA A2*01-GVYDGREHTV

Summary for 6TRO

• Entry DOI: 10.2210/pdb6tro/pdb
• Related: 6TRN
• Descriptor: MHC class I antigen, Beta-2-microglobulin, MAGE-A4 peptide (amino acids 230-239), ... (6 entities in total)
• Functional Keywords: human leukocyte antigen, mage-a4, t-cell receptor, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 96383.17

Authors

Coles, C.H.,McMurran, C.,Lloyd, A.,Hibbert, L.,Lupardus, P.J.,Cole, D.K.,Harper, S. (deposition date: 2019-12-19, release date: 2020-06-24, Last modification date: 2024-01-24)

• Primary citation: Coles, C.H.,McMurran, C.,Lloyd, A.,Hock, M.,Hibbert, L.,Raman, M.C.C.,Hayes, C.,Lupardus, P.,Cole, D.K.,Harper, S.; T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.; J.Biol.Chem., 295:11486-11494, 2020; PubMed: 32532817; DOI: 10.1074/jbc.RA120.014016

Experimental method

X-RAY DIFFRACTION (3 Å)