Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1FPV
DownloadVisualize
BU of 1fpv by Molmil
STRUCTURE DETERMINATION OF FELINE PANLEUKOPENIA VIRUS EMPTY PARTICLES
Descriptor: FELINE PANLEUKOPENIA VIRUS (STRAIN B) VIRAL PROTEIN 2
Authors:Agbandje, M, Rossmann, M.G.
Deposit date:1993-03-04
Release date:1994-01-31
Last modified:2023-04-19
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure determination of feline panleukopenia virus empty particles.
Proteins, 16, 1993
8RD2
DownloadVisualize
BU of 8rd2 by Molmil
Trypanosoma brucei Invariant Surface Glycoprotein 75 (ISG75)
Descriptor: Invariant surface glycoprotein
Authors:Stodkilde-Jorgensen, K, Mikkelsen, J.H.
Deposit date:2023-12-07
Release date:2024-02-14
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Trypanosoma brucei Invariant Surface Glycoprotein 75 Is an Immunoglobulin Fc Receptor Inhibiting Complement Activation and Antibody-Mediated Cellular Phagocytosis.
J Immunol., 212, 2024
1JVW
DownloadVisualize
BU of 1jvw by Molmil
TRYPANOSOMA CRUZI MACROPHAGE INFECTIVITY POTENTIATOR (TCMIP)
Descriptor: MACROPHAGE INFECTIVITY POTENTIATOR
Authors:Pereira, P.J.B, Vega, M.C, Gonzalez-Rey, E, Fernandez-Carazo, R, Macedo-Ribeiro, S, Gomis-Rueth, F.X, Gonzalez, A, Coll, M.
Deposit date:2001-08-31
Release date:2002-06-05
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Trypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed alpha-helix.
EMBO Rep., 3, 2002
2CNB
DownloadVisualize
BU of 2cnb by Molmil
Trypanosoma brucei UDP-galactose-4-epimerase in ternary complex with NAD and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-GALACTOSE-4-EPIMERASE, URIDINE-5'-DIPHOSPHATE-4-DEOXY-4-FLUORO-ALPHA-D-GALACTOSE
Authors:Alphey, M.S, Ferguson, M.A.J, Hunter, W.N.
Deposit date:2006-05-18
Release date:2006-06-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Trypanosoma Brucei Udp-Galactose-4-Epimerase in Ternary Complex with Nad+ and the Substrate Analogue Udp-4-Deoxy-4-Fluoro-Alpha-D-Galactose
Acta Crystallogr.,Sect.F, 62, 2006
7F8J
DownloadVisualize
BU of 7f8j by Molmil
Cryo-EM structure of human pannexin-1 in a nanodisc
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1
Authors:Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A.
Deposit date:2021-07-02
Release date:2022-01-26
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids.
Sci.Signal., 15, 2022
7F8N
DownloadVisualize
BU of 7f8n by Molmil
Human pannexin-1 showing a conformational change in the N-terminal domain and blocked pore
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1
Authors:Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A.
Deposit date:2021-07-02
Release date:2022-01-26
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids.
Sci.Signal., 15, 2022
1QJC
DownloadVisualize
BU of 1qjc by Molmil
Phosphopantetheine Adenylyltransferase from Escherichia coli in complex with 4'-phosphopantetheine
Descriptor: 4'-PHOSPHOPANTETHEINE, PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE, SULFATE ION
Authors:Izard, T.
Deposit date:1999-06-23
Release date:2001-06-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:The Crystal Structures of Phosphopantetheine Adenylyltransferase with Bound Substrates Reveal the Enzyme'S Catalytic Mechanism
J.Mol.Biol., 315, 2001
6CI9
DownloadVisualize
BU of 6ci9 by Molmil
RMM microcompartment-associated aminopropanol dehydrogenase NADP + aminoacetone holo-structure
Descriptor: 1-aminopropan-2-one, 3-oxoacyl-[acyl-carrier-protein] reductase, CHLORIDE ION, ...
Authors:Mallette, E, Kimber, M.S.
Deposit date:2018-02-23
Release date:2018-05-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Kinetics of the S-(+)-1-Amino-2-propanol Dehydrogenase from the RMM Microcompartment of Mycobacterium smegmatis.
Biochemistry, 57, 2018
1NL6
DownloadVisualize
BU of 1nl6 by Molmil
Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor
Descriptor: 5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ACID ((S)-3-METHYL-1-{(S)-3-OXO-1-[2-(3-PYRIDIN-2-YLPHENYL)ACETYL]AZEPAN-4-YLCARBAMOYL}BUTYL)AMIDE, Cathepsin K
Authors:Smith, W.W, Janson, C.A, Zhao, B.
Deposit date:2003-01-06
Release date:2003-01-14
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Azepanone-based inhibitors of human and rat cathepsin K
J.Med.Chem., 44, 2001
1NLJ
DownloadVisualize
BU of 1nlj by Molmil
CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT AZEPANONE INHIBITOR
Descriptor: BENZOFURAN-2-CARBOXYLIC ACID {(S)-3-METHYL-1-[3-OXO-1-(PYRIDIN-2-YLSULFONYL)AZEPAN-4-YLCARBAMOYL]BUTYL}AMIDE, CATHEPSIN K
Authors:Smith, W.W, Janson, C.A, Zhao, B.
Deposit date:2003-01-07
Release date:2003-01-14
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Azepanone-Based Inhibitors of Human and Rat Cathepsin K
J.Med.Chem., 44, 2001
1OY0
DownloadVisualize
BU of 1oy0 by Molmil
The crystal Structure of the First Enzyme of Pantothenate Biosynthetic Pathway, Ketopantoate Hydroxymethyltransferase from Mycobacterium Tuberculosis Shows a Decameric Assembly and Terminal Helix-Swapping
Descriptor: Ketopantoate hydroxymethyltransferase, MAGNESIUM ION
Authors:Chaudhuri, B.N, Sawaya, M.R, Kim, C.Y, Waldo, G.S, Park, M.S, Terwilliger, T.C, Yeates, T.O, TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-04-03
Release date:2003-07-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of the First Enzyme in the Pantothenate Biosynthetic Pathway, Ketopantoate Hydroxymethyltransferase, from M. tuberculosis
Structure, 11, 2003
3BEX
DownloadVisualize
BU of 3bex by Molmil
Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate
Descriptor: PANTOTHENOIC ACID, PHOSPHATE ION, Type III pantothenate kinase
Authors:Yang, K, Huerta, C, Strauss, E, Zhang, H.
Deposit date:2007-11-20
Release date:2008-06-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.
Biochemistry, 47, 2008
2OO0
DownloadVisualize
BU of 2oo0 by Molmil
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane
Descriptor: 3-AMINOOXY-1-AMINOPROPANE, ACETATE ION, Ornithine decarboxylase, ...
Authors:Dufe, V.T, Ingner, D, Khomutov, A.R, Heby, O, Persson, L, Al-Karadaghi, S.
Deposit date:2007-01-25
Release date:2007-07-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.
Biochem.J., 405, 2007
5DXU
DownloadVisualize
BU of 5dxu by Molmil
p110delta/p85alpha with GDC-0326
Descriptor: (2S)-2-({2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}oxy)propanamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Authors:Heffron, T.P, Heald, R.A, Ndubaku, C, Wei, B.Q, Augustin, M, Do, S, Edgar, K, Eigenbrot, C, Friedman, L, Gancia, E, Jackson, P.S, Jones, G, Kolesnikov, A, Lee, L.B, Lesnick, J.D, Lewis, C, McLean, N, Mortle, M, Nonomiya, J, Pang, J, Price, S, Prior, W.W, Salphati, L, Sideris, S, Staben, S.T, Steinbacher, S, Tsui, V, Wallin, J, Sampath, D, Olivero, A.
Deposit date:2015-09-23
Release date:2016-01-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
J.Med.Chem., 59, 2016
5DXT
DownloadVisualize
BU of 5dxt by Molmil
p110alpha with GDC-0326
Descriptor: (2S)-2-({2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}oxy)propanamide, 1,2-ETHANEDIOL, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Heffron, T.P, Heald, R.A, Ndubaku, C, Wei, B.Q, Augustin, M, Do, S, Edgar, K, Eigenbrot, C, Friedman, L, Gancia, E, Jackson, P.S, Jones, G, Kolesnikov, A, Lee, L.B, Lesnick, J.D, Lewis, C, McLean, N, Mortle, M, Nonomiya, J, Pang, J, Price, S, Prior, W.W, Salphati, L, Sideris, S, Staben, S.T, Steinbacher, S, Tsui, V, Wallin, J, Sampath, D, Olivero, A.
Deposit date:2015-09-23
Release date:2016-01-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
J.Med.Chem., 59, 2016
2ON3
DownloadVisualize
BU of 2on3 by Molmil
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane
Descriptor: 3-AMINOOXY-1-AMINOPROPANE, Ornithine decarboxylase
Authors:Dufe, V.T, Ingner, D, Heby, O, Khomutov, A.R, Persson, L, Al-Karadaghi, S.
Deposit date:2007-01-23
Release date:2007-07-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.
Biochem.J., 405, 2007
8GTR
DownloadVisualize
BU of 8gtr by Molmil
CryoEM structure of human Pannexin isoform 3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATIDYLETHANOLAMINE, Pannexin-3
Authors:Hussain, N, Penmatsa, A.
Deposit date:2022-09-08
Release date:2024-02-28
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms.
Nat Commun, 15, 2024
7UE6
DownloadVisualize
BU of 7ue6 by Molmil
PANK3 complex structure with compound PZ-3802
Descriptor: 1,2-ETHANEDIOL, 6-(4-{[5-fluoro-6-(propan-2-yl)pyridin-3-yl]acetyl}piperazin-1-yl)pyridazine-3-carbonitrile, ACETATE ION, ...
Authors:White, S.W, Yun, M, Lee, R.E.
Deposit date:2022-03-21
Release date:2023-04-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Discovery of hPANK Activators with Improved Pharmacological Properties
To Be Published
7UE5
DownloadVisualize
BU of 7ue5 by Molmil
PANK3 complex structure with compound PZ-3741
Descriptor: 6-[4-({4-[(2R)-1,1,1-trifluoropropan-2-yl]phenyl}acetyl)piperazin-1-yl]pyridazine-3-carbonitrile, 6-[4-({4-[(2S)-1,1,1-trifluoropropan-2-yl]phenyl}acetyl)piperazin-1-yl]pyridazine-3-carbonitrile, MAGNESIUM ION, ...
Authors:White, S.W, Yun, M, Lee, R.E.
Deposit date:2022-03-21
Release date:2023-03-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Discovery of hPANK Activators with Improved Pharmacological Properties
To Be Published
7UE3
DownloadVisualize
BU of 7ue3 by Molmil
PANK3 complex structure with compound PZ-3804
Descriptor: 1,2-ETHANEDIOL, 6-[4-({4-[(2R)-1-hydroxypropan-2-yl]phenyl}acetyl)piperazin-1-yl]pyridazine-3-carbonitrile, MAGNESIUM ION, ...
Authors:White, S.W, Yun, M, Lee, R.E.
Deposit date:2022-03-21
Release date:2023-03-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Discovery of hPANK Activators with Improved Pharmacological Properties
To Be Published
3AVP
DownloadVisualize
BU of 3avp by Molmil
Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with Pantothenol
Descriptor: (2S)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, CITRATE ANION, GLYCEROL, ...
Authors:Chetnani, B, Kumar, P, Abhinav, K.V, Chhibber, M, Surolia, A, Vijayan, M.
Deposit date:2011-03-06
Release date:2011-08-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Location and conformation of pantothenate and its derivatives in Mycobacterium tuberculosis pantothenate kinase: insights into enzyme action
Acta Crystallogr.,Sect.D, 67, 2011
8WBH
DownloadVisualize
BU of 8wbh by Molmil
CryoEM structure of non-structural protein 1 tetramer from Japanese encephalitis virus
Descriptor: Genome polyprotein
Authors:Jiao, H.Z, Pan, Q, Hu, H.L.
Deposit date:2023-09-09
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The step-by-step assembly mechanism of secreted flavivirus NS1 tetramer and hexamer captured at atomic resolution.
Sci Adv, 10, 2024
3AVQ
DownloadVisualize
BU of 3avq by Molmil
Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan
Descriptor: (2S)-2,4-dihydroxy-3,3-dimethyl-N-[3-(nonylamino)-3-oxopropyl]butanamide, CITRATE ANION, GLYCEROL, ...
Authors:Chetnani, B, Kumar, P, Abhinav, K.V, Chhibber, M, Surolia, A, Vijayan, M.
Deposit date:2011-03-06
Release date:2011-08-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Location and conformation of pantothenate and its derivatives in Mycobacterium tuberculosis pantothenate kinase: insights into enzyme action
Acta Crystallogr.,Sect.D, 67, 2011
6AGF
DownloadVisualize
BU of 6agf by Molmil
Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pan, X.J, li, Z.Q, Zhou, Q, Shen, H.Z, Wu, K, Huang, X.S, Chen, J.F, Zhang, J.R, Zhu, X.C, Lei, J.L, Xiong, W, Gong, H.P, Xiao, B.L, Yan, N.
Deposit date:2018-08-11
Release date:2018-10-10
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta 1.
Science, 362, 2018
3WXK
DownloadVisualize
BU of 3wxk by Molmil
Crystal structure of trypanosoma brucei gambiense glycerol kinase in complex with glycerol
Descriptor: GLYCEROL, Glycerol kinase, HEXANE-1,6-DIOL
Authors:Balogun, E.O, Inaoka, D.K, Shiba, T, Kido, Y, Tsuge, C, Nara, T, Aoki, T, Honma, T, Tanaka, A, Inoue, M, Matsuoka, S, Michels, P.A.M, Kita, K, Harada, S.
Deposit date:2014-08-01
Release date:2014-12-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase.
Mol.Microbiol., 94, 2014

221716

数据于2024-06-26公开中

PDB statisticsPDBj update infoContact PDBjnumon