Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with Pantothenol

Summary for 3AVP

Related3AEZ 3AF0 3AF1 3AF2 3AF3 3AF4 3AVO 3AVQ
DescriptorPantothenate kinase, (2S)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, CITRATE ANION, ... (6 entities in total)
Functional Keywordshomodimer, coa biosynthesis, nucleotide binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMycobacterium tuberculosis
Cellular locationCytoplasm (Probable) P63810
Total number of polymer chains1
Total molecular weight37158.21
Chetnani, B.,Kumar, P.,Abhinav, K.V.,Chhibber, M.,Surolia, A.,Vijayan, M. (deposition date: 2011-03-06, release date: 2011-08-17, Last modification date: 2011-11-02)
Primary citation
Chetnani, B.,Kumar, P.,Abhinav, K.V.,Chhibber, M.,Surolia, A.,Vijayan, M.
Location and conformation of pantothenate and its derivatives in Mycobacterium tuberculosis pantothenate kinase: insights into enzyme action
Acta Crystallogr.,Sect.D, 67:774-783, 2011
PubMed: 21904030 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444911024462
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23418 2.3% 2.3% 2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28