6S8E
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![BU of 6s8e by Molmil](/molmil-images/mine/6s8e) | Cryo-EM structure of the type III-B Cmr-beta complex bound to non-cognate target RNA | Descriptor: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | Authors: | Sofos, N, Montoya, G, Stella, S. | Deposit date: | 2019-07-09 | Release date: | 2020-07-08 | Last modified: | 2020-09-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas. Mol.Cell, 79, 2020
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6SH8
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![BU of 6sh8 by Molmil](/molmil-images/mine/6sh8) | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 2, in the presence of ssDNA | Descriptor: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | Authors: | Sofos, N, Montoya, G, Stella, S. | Deposit date: | 2019-08-06 | Release date: | 2020-07-08 | Last modified: | 2020-09-16 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas. Mol.Cell, 79, 2020
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6YEM
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![BU of 6yem by Molmil](/molmil-images/mine/6yem) | H1N1 2009 PA Endonuclease in complex with Quambalarine B | Descriptor: | 3,5,6,8-tetrakis(oxidanyl)-2-pentanoyl-naphthalene-1,4-dione, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Radilova, K, Brynda, J. | Deposit date: | 2020-03-25 | Release date: | 2020-09-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors. Eur.J.Med.Chem., 208, 2020
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6EXP
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![BU of 6exp by Molmil](/molmil-images/mine/6exp) | Crystal structure of the SIRV3 AcrID1 (gp02) anti-CRISPR protein | Descriptor: | SIRV3 AcrID1 (gp02) anti-CRISPR protein | Authors: | He, F, Bhoobalan-Chitty, Y, Van, L.B, Kjeldsen, A.L, Dedola, M, Makarova, K.S, Koonin, E.V, Brodersen, D.E, Peng, X. | Deposit date: | 2017-11-08 | Release date: | 2018-01-31 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity. Nat Microbiol, 3, 2018
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6IWG
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![BU of 6iwg by Molmil](/molmil-images/mine/6iwg) | Crystal structure of rhesus macaque MHC class I molecule Mamu-B*05104 complexed with N-myristoylated 4-mer lipopeptide derived from SIV nef protein | Descriptor: | 1,2-ETHANEDIOL, BORIC ACID, Beta-2-microglobulin, ... | Authors: | Yamamoto, Y, Morita, D, Sugita, M. | Deposit date: | 2018-12-05 | Release date: | 2019-08-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Identification and Structure of an MHC Class I-Encoded Protein with the Potential to PresentN-Myristoylated 4-mer Peptides to T Cells. J Immunol., 202, 2019
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6M4D
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![BU of 6m4d by Molmil](/molmil-images/mine/6m4d) | Structural mechanism of nucleosome dynamics governed by human histone variants H2A.B and H2A.Z.2.2 | Descriptor: | DNA (125-MER), Histone H2A.V, Histone H2B type 2-E, ... | Authors: | Zhou, M, Dai, L.C, Li, C.M, Shi, L.X, Huang, Y, Guo, Z.Q. | Deposit date: | 2020-03-06 | Release date: | 2020-09-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2. Embo J., 40, 2021
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6SHB
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![BU of 6shb by Molmil](/molmil-images/mine/6shb) | Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1, in the presence of ssDNA | Descriptor: | CRISPR-associated RAMP protein, Cmr4 family, Cmr6 family, ... | Authors: | Sofos, N, Montoya, G, Stella, S. | Deposit date: | 2019-08-06 | Release date: | 2020-07-08 | Last modified: | 2020-09-16 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas. Mol.Cell, 79, 2020
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6B1B
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![BU of 6b1b by Molmil](/molmil-images/mine/6b1b) | STRUCTURE OF 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE (HPAB), OXYGENASE COMPONENT FROM ESCHERICHIA COLI MUTANT XS6 (APO Enzyme) | Descriptor: | 4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit, trimethylamine oxide | Authors: | Zhou, D, Kandavelu, P, Wang, B.C, Yan, Y, Rose, J.P. | Deposit date: | 2017-09-18 | Release date: | 2019-05-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.944 Å) | Cite: | Structural Insights into Catalytic Versatility of the Flavin-dependent Hydroxylase (HpaB) from Escherichia coli. Sci Rep, 9, 2019
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5KF8
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![BU of 5kf8 by Molmil](/molmil-images/mine/5kf8) | X-ray structure of a glucosamine N-Acetyltransferase from Clostridium acetobutylicum in complex with glucosamine | Descriptor: | 1,2-ETHANEDIOL, 2-amino-2-deoxy-beta-D-glucopyranose, 3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PROPANE-1-SULFONIC ACID, ... | Authors: | Holden, H.M, Thoden, J.B, Dopkins, B.J, Tipton, P.A. | Deposit date: | 2016-06-12 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Studies on a Glucosamine/Glucosaminide N-Acetyltransferase. Biochemistry, 55, 2016
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7KDU
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![BU of 7kdu by Molmil](/molmil-images/mine/7kdu) | Ricin bound to VHH antibody V5E4 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ricin chain A, ... | Authors: | Rudolph, M.J. | Deposit date: | 2020-10-09 | Release date: | 2021-08-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.809 Å) | Cite: | Structural Analysis of Toxin-Neutralizing, Single-Domain Antibodies that Bridge Ricin's A-B Subunit Interface. J.Mol.Biol., 433, 2021
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6SG4
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![BU of 6sg4 by Molmil](/molmil-images/mine/6sg4) | Structure of CDK2/cyclin A M246Q, S247EN | Descriptor: | Cyclin-A2, Cyclin-dependent kinase 2 | Authors: | Salamina, M, Basle, A, Massa, B, Noble, M.E.M, Endicott, J.A. | Deposit date: | 2019-08-02 | Release date: | 2021-01-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation. J.Mol.Biol., 433, 2021
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7KD2
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![BU of 7kd2 by Molmil](/molmil-images/mine/7kd2) | Ricin bound to VHH antibody V11B2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Ricin chain A, ... | Authors: | Rudolph, M.J. | Deposit date: | 2020-10-07 | Release date: | 2021-08-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural Analysis of Toxin-Neutralizing, Single-Domain Antibodies that Bridge Ricin's A-B Subunit Interface. J.Mol.Biol., 433, 2021
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5JE1
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![BU of 5je1 by Molmil](/molmil-images/mine/5je1) | Crystal structure of Burkholderia glumae ToxA with bound S-adenosylhomocysteine (SAH) and toxoflavin | Descriptor: | 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione, Methyl transferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Fenwick, M.K, Philmus, B, Begley, T.P, Ealick, S.E. | Deposit date: | 2016-04-17 | Release date: | 2016-05-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Burkholderia glumae ToxA Is a Dual-Specificity Methyltransferase That Catalyzes the Last Two Steps of Toxoflavin Biosynthesis. Biochemistry, 55, 2016
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7ZWN
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![BU of 7zwn by Molmil](/molmil-images/mine/7zwn) | Crystal structure of human BCL6 BTB domain in complex with a WVIP peptide | Descriptor: | 1,2-ETHANEDIOL, ALA-TRP-VAL-ILE-PRO-ALA, B-cell lymphoma 6 protein, ... | Authors: | Shetty, K, Le Bihan, Y.-V, van Montfort, R.L.M. | Deposit date: | 2022-05-19 | Release date: | 2022-11-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays. Sci Rep, 12, 2022
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7K81
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![BU of 7k81 by Molmil](/molmil-images/mine/7k81) | KIR3DL1*005 in complex with HLA-A*24:02 presenting the RYPLTFGW peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ARG-TYR-PRO-LEU-THR-PHE-GLY-TRP, Beta-2-microglobulin, ... | Authors: | MacLachlan, B.J, Rossjohn, J, Vivian, J.P. | Deposit date: | 2020-09-24 | Release date: | 2020-12-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Role of the HLA Class I alpha 2 Helix in Determining Ligand Hierarchy for the Killer Cell Ig-like Receptor 3DL1. J Immunol., 206, 2021
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6SL4
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![BU of 6sl4 by Molmil](/molmil-images/mine/6sl4) | The unique CBM-Cthe_0271 of Ruminiclostridium thermocellum | Descriptor: | CALCIUM ION, Type 3a cellulose-binding domain protein | Authors: | Milana, M.V, Almog, R, Yaniv, O, Oded, L, Inna, R.G, Felix, F, Edward, A.B, Raphael, L. | Deposit date: | 2019-08-18 | Release date: | 2020-03-18 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The unique CBM-Cthe_0271 of Ruminiclostridium thermocellum To Be Published
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8D8I
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![BU of 8d8i by Molmil](/molmil-images/mine/8d8i) | Crystal structure of Reverb alpha in complex with synthetic agonist | Descriptor: | (4S)-6-[([1,1'-biphenyl]-2-yl)oxy]-3-chloro[1,2,4]triazolo[4,3-b]pyridazine, Nuclear receptor corepressor 1, Nuclear receptor subfamily 1 group D member 1 | Authors: | Ronin, C, Ciesielski, F, Hegazy, L, Burris, P.T. | Deposit date: | 2022-06-08 | Release date: | 2022-12-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.504 Å) | Cite: | Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB. Nat Commun, 13, 2022
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7Z77
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![BU of 7z77 by Molmil](/molmil-images/mine/7z77) | Crystal structure of compound 6 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-~{N}-[(1~{S})-4-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]butyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Bader, G, Boettcher, J, Wolkerstorfer, B. | Deposit date: | 2022-03-15 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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1FXF
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![BU of 1fxf by Molmil](/molmil-images/mine/1fxf) | CARBOXYLIC ESTER HYDROLASE COMPLEX (DIMERIC PLA2 + MJ33 INHIBITOR + PHOSPHATE IONS) | Descriptor: | 1-HEXADECYL-3-TRIFLUOROETHYL-SN-GLYCERO-2-PHOSPHATE METHANE, CALCIUM ION, PHOSPHATE ION, ... | Authors: | Pan, Y.H, Epstein, T.M, Jain, M.K, Bahnson, B.J. | Deposit date: | 2000-09-25 | Release date: | 2001-09-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding. Biochemistry, 40, 2001
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7Z76
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![BU of 7z76 by Molmil](/molmil-images/mine/7z76) | Crystal structure of compound 10 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-~{N}-[(1~{R})-2-[(2~{R})-1-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propan-2-yl]oxy-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-1-[(2~{S})-2-[[1-(dimethylamino)cyclopropyl]carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Bader, G, Boettcher, J, Wolkerstorfer, B. | Deposit date: | 2022-03-15 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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6VBQ
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![BU of 6vbq by Molmil](/molmil-images/mine/6vbq) | |
4WZK
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![BU of 4wzk by Molmil](/molmil-images/mine/4wzk) | |
4WZT
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6Q8H
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![BU of 6q8h by Molmil](/molmil-images/mine/6q8h) | Structure of Fucosylated D-antimicrobial peptide SB10 in complex with the Fucose-binding lectin PA-IIL at 1.707 Angstrom resolution | Descriptor: | 3,7-anhydro-2,8-dideoxy-L-glycero-D-gluco-octonic acid, AMINO GROUP, CALCIUM ION, ... | Authors: | Baeriswyl, S, Stocker, A, Reymond, J.L. | Deposit date: | 2018-12-14 | Release date: | 2019-03-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.707 Å) | Cite: | X-ray Crystal Structures of Short Antimicrobial Peptides as Pseudomonas aeruginosa Lectin B Complexes. Acs Chem.Biol., 14, 2019
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5GM1
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![BU of 5gm1 by Molmil](/molmil-images/mine/5gm1) | Crystal structure of methyltransferase TleD complexed with SAH | Descriptor: | O-methylransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Yu, F, Li, M.J, Xu, C.Y, Zhou, H, Sun, B, Wang, Z.J, Xu, Q, Xie, M.Y, Zuo, G, Huang, P, Wang, Q.S, He, J.H. | Deposit date: | 2016-07-12 | Release date: | 2016-09-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Crystal structure and enantioselectivity of terpene cyclization in SAM-dependent methyltransferase TleD Biochem.J., 473, 2016
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