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7Z76

Crystal structure of compound 10 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB

Summary for 7Z76
Entry DOI10.2210/pdb7z76/pdb
Related7Z6L
DescriptorElongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (7 entities in total)
Functional Keywordsprotac, complex, bromodomain, ligase
Biological sourceHomo sapiens (human)
More
Total number of polymer chains4
Total formula weight57771.36
Authors
Bader, G.,Boettcher, J.,Wolkerstorfer, B. (deposition date: 2022-03-15, release date: 2022-09-14, Last modification date: 2024-01-31)
Primary citationKofink, C.,Trainor, N.,Mair, B.,Wohrle, S.,Wurm, M.,Mischerikow, N.,Roy, M.J.,Bader, G.,Greb, P.,Garavel, G.,Diers, E.,McLennan, R.,Whitworth, C.,Vetma, V.,Rumpel, K.,Scharnweber, M.,Fuchs, J.E.,Gerstberger, T.,Cui, Y.,Gremel, G.,Chetta, P.,Hopf, S.,Budano, N.,Rinnenthal, J.,Gmaschitz, G.,Mayer, M.,Koegl, M.,Ciulli, A.,Weinstabl, H.,Farnaby, W.
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.
Nat Commun, 13:5969-5969, 2022
Cited by
PubMed: 36216795
DOI: 10.1038/s41467-022-33430-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.32 Å)
Structure validation

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