5KKL
| Structure of ctPRC2 in complex with H3K27me3 and H3K27M | Descriptor: | ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA, Putative uncharacterized protein,Histone H3.1 peptide,Zinc finger domain-containing protein, S-ADENOSYLMETHIONINE, ... | Authors: | Jiao, L, Liu, X. | Deposit date: | 2016-06-21 | Release date: | 2017-04-19 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2". Science, 354, 2016
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7TD5
| Structure of human PRC2-EZH1 containing phosphorylated SUZ12 | Descriptor: | Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, Polycomb protein SUZ12, ... | Authors: | Gong, L, Jiao, L, Liu, X. | Deposit date: | 2021-12-30 | Release date: | 2022-11-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.994 Å) | Cite: | CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site. Nat Commun, 13, 2022
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7MBN
| Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode02 | Descriptor: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Park, S.H, Ayoub, A, Lee, Y.T, Dou, Y, Cho, U. | Deposit date: | 2021-04-01 | Release date: | 2021-12-29 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY | Cite: | Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes. Biochemistry, 61, 2022
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7MBM
| Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode01 | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Park, S.H, Ayoub, A, Lee, Y.T, Dou, Y, Cho, U. | Deposit date: | 2021-04-01 | Release date: | 2021-12-29 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY | Cite: | Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes. Biochemistry, 61, 2022
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5F6L
| The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L | Descriptor: | Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Li, Y, Lei, M, Chen, Y. | Deposit date: | 2015-12-06 | Release date: | 2016-02-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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5F6K
| Crystal structure of the MLL3-Ash2L-RbBP5 complex | Descriptor: | Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Li, Y, Lei, M, Chen, Y. | Deposit date: | 2015-12-06 | Release date: | 2016-02-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.411 Å) | Cite: | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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7AT8
| Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2. | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3.2, ... | Authors: | Finogenova, K, Benda, C, Schaefer, I.B, Poepsel, S, Strauss, M, Mueller, J. | Deposit date: | 2020-10-29 | Release date: | 2020-12-09 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3. Elife, 9, 2020
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7BRE
| The crystal structure of MLL2 in complex with ASH2L and RBBP5 | Descriptor: | Histone-lysine N-methyltransferase 2B, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Li, Y, Zhao, L, Chen, Y. | Deposit date: | 2020-03-28 | Release date: | 2020-07-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.803 Å) | Cite: | Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases. Structure, 28, 2020
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4W2R
| Structure of Hs/AcPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | Descriptor: | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of zeste 2 polycomb repressive complex 2 subunit, Polycomb protein EED, ... | Authors: | Gajiwala, K.S, Brooun, A, Liu, W, Deng, Y, Stewart, A.E. | Deposit date: | 2017-09-25 | Release date: | 2017-12-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J. Med. Chem., 61, 2018
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6NZO
| Set2 bound to nucleosome | Descriptor: | DNA (149-MER), Histone H2B 1.1, Histone H3, ... | Authors: | Halic, M, Bilokapic, S. | Deposit date: | 2019-02-14 | Release date: | 2019-08-28 | Last modified: | 2019-09-04 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Nucleosome and ubiquitin position Set2 to methylate H3K36. Nat Commun, 10, 2019
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8T9F
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8T9H
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8SWI
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8SR6
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5BJS
| Apo ctPRC2 in an autoinhibited state | Descriptor: | Histone-lysine N-methyltransferase EZH2, Polycomb protein SUZ12, Polycomb Protein EED, ... | Authors: | Bratkowski, M.A, Liu, X. | Deposit date: | 2016-10-22 | Release date: | 2017-06-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.189 Å) | Cite: | Polycomb repressive complex 2 in an autoinhibited state. J. Biol. Chem., 292, 2017
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8W9Z
| The cryo-EM structure of the Nicotiana tabacum PEP-PAP | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta'', ... | Authors: | Wu, X.X, Zhang, Y. | Deposit date: | 2023-09-06 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures of the plant plastid-encoded RNA polymerase. Cell, 187, 2024
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8WA1
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8WA0
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6KIX
| Cryo-EM structure of human MLL1-NCP complex, binding mode1 | Descriptor: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | Authors: | Huang, J, Xue, H, Yao, T. | Deposit date: | 2019-07-20 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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6KIV
| Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Huang, J, Xue, H, Yao, T. | Deposit date: | 2019-07-20 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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6KIZ
| Cryo-EM structure of human MLL1-NCP complex, binding mode2 | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Huang, J, Xue, H, Yao, T. | Deposit date: | 2019-07-20 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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5CZY
| Crystal structure of LegAS4 | Descriptor: | GLYCEROL, Legionella effector LegAS4, S-ADENOSYLMETHIONINE | Authors: | Son, J, Hwang, K.Y, Lee, W.C. | Deposit date: | 2015-08-01 | Release date: | 2015-09-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Legionella pneumophila type IV secretion system effector LegAS4 Biochem.Biophys.Res.Commun., 465, 2015
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7CRQ
| NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode) | Descriptor: | DNA (168-MER), Histone H2A, Histone H2B, ... | Authors: | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | Deposit date: | 2020-08-14 | Release date: | 2020-10-21 | Last modified: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Nature, 590, 2021
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7CRP
| NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode) | Descriptor: | DNA (168-MER), Histone H2A, Histone H2B, ... | Authors: | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | Deposit date: | 2020-08-14 | Release date: | 2020-10-21 | Last modified: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Nature, 590, 2021
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7E8D
| NSD2 E1099K mutant bound to nucleosome | Descriptor: | DNA (185-MER), Histone H2A type 1, Histone H2B type 1-J, ... | Authors: | Sengoku, T, Sato, K, Nishizawa, T, Nureki, O, Ogata, K. | Deposit date: | 2021-03-01 | Release date: | 2021-11-10 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2. Nat Commun, 12, 2021
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