6R8Z
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![BU of 6r8z by Molmil](/molmil-images/mine/6r8z) | Cryo-EM structure of NCP_THF2(-1)-UV-DDB | Descriptor: | DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... | Authors: | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-04-02 | Release date: | 2019-06-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
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6R8Y
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![BU of 6r8y by Molmil](/molmil-images/mine/6r8y) | Cryo-EM structure of NCP-6-4PP(-1)-UV-DDB | Descriptor: | DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... | Authors: | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-04-02 | Release date: | 2019-06-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
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7LFQ
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![BU of 7lfq by Molmil](/molmil-images/mine/7lfq) | Pyrococcus RNA ligase | Descriptor: | DNA (5'-D(*AP*TP*GP*TP*CP*C)-3'), POTASSIUM ION, RNA-splicing ligase RtcB, ... | Authors: | Goldgur, Y, Shuman, S, Banerjee, A. | Deposit date: | 2021-01-18 | Release date: | 2021-03-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of 3'-PO 4 /5'-OH RNA ligase RtcB in complex with a 5'-OH oligonucleotide. Rna, 27, 2021
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6M2V
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![BU of 6m2v by Molmil](/molmil-images/mine/6m2v) | Crystal structure of UHRF1 SRA complexed with fully-mCHG DNA. | Descriptor: | DNA (5'-D(*TP*CP*AP*CP*GP*(5CM)P*TP*GP*CP*GP*TP*GP*A)-3'), E3 ubiquitin-protein ligase UHRF1 | Authors: | Abhishek, S, Nakarakanti, N.K, Deeksha, W, Rajakumara, E. | Deposit date: | 2020-03-01 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Mechanistic insights into recognition of symmetric methylated cytosines in CpG and non-CpG DNA by UHRF1 SRA. Int.J.Biol.Macromol., 170, 2021
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6R92
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![BU of 6r92 by Molmil](/molmil-images/mine/6r92) | Cryo-EM structure of NCP-THF2(+1)-UV-DDB class B | Descriptor: | DNA damage-binding protein 1,DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... | Authors: | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-04-02 | Release date: | 2019-06-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | DNA damage detection in nucleosomes involves DNA register shifting. Nature, 571, 2019
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2ZKD
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![BU of 2zkd by Molmil](/molmil-images/mine/2zkd) | Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(*DCP*DTP*DAP*DCP*DCP*DGP*DGP*DAP*DTP*DTP*DGP*DC)-3'), ... | Authors: | Arita, K, Ariyoshi, M, Tochio, H, Nakamura, Y, Shirakawa, M. | Deposit date: | 2008-03-19 | Release date: | 2008-09-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism Nature, 455, 2008
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8EWV
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![BU of 8ewv by Molmil](/molmil-images/mine/8ewv) | DNA-encoded library (DEL)-enabled discovery of proximity inducing small molecules | Descriptor: | Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... | Authors: | Schreiber, S.L, Shu, W, Ma, X, Michaud, G, Bonazzi, S, Berst, F. | Deposit date: | 2022-10-24 | Release date: | 2023-10-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | DNA-encoded library-enabled discovery of proximity-inducing small molecules. Nat.Chem.Biol., 20, 2024
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4CI3
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![BU of 4ci3 by Molmil](/molmil-images/mine/4ci3) | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide | Descriptor: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ... | Authors: | Fischer, E.S, Boehm, K, Thoma, N.H. | Deposit date: | 2013-12-05 | Release date: | 2014-07-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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4CI2
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![BU of 4ci2 by Molmil](/molmil-images/mine/4ci2) | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide | Descriptor: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ... | Authors: | Fischer, E.S, Boehm, K, Thoma, N.H. | Deposit date: | 2013-12-05 | Release date: | 2014-07-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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4CI1
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![BU of 4ci1 by Molmil](/molmil-images/mine/4ci1) | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide | Descriptor: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Thalidomide, ... | Authors: | Fischer, E.S, Boehm, K, Thoma, N.H. | Deposit date: | 2013-12-05 | Release date: | 2014-07-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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6Q00
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![BU of 6q00 by Molmil](/molmil-images/mine/6q00) | TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 1 | Descriptor: | POTASSIUM ION, Tyrosyl-DNA phosphodiesterase 2, Ubiquitin | Authors: | Schellenberg, M.J, Krahn, J.M, Williams, R.S. | Deposit date: | 2019-08-01 | Release date: | 2020-04-29 | Last modified: | 2020-06-24 | Method: | X-RAY DIFFRACTION (0.85 Å) | Cite: | Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2. Nucleic Acids Res., 48, 2020
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5CKK
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![BU of 5ckk by Molmil](/molmil-images/mine/5ckk) | |
3SR2
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![BU of 3sr2 by Molmil](/molmil-images/mine/3sr2) | Crystal Structure of Human XLF-XRCC4 Complex | Descriptor: | DNA repair protein XRCC4, Non-homologous end-joining factor 1 | Authors: | Hammel, M, Classen, S, Tainer, J.A. | Deposit date: | 2011-07-06 | Release date: | 2011-07-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.9708 Å) | Cite: | XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair. J.Biol.Chem., 286, 2011
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6WGG
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![BU of 6wgg by Molmil](/molmil-images/mine/6wgg) | Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (41-MER), ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (8.1 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
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6WGI
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![BU of 6wgi by Molmil](/molmil-images/mine/6wgi) | Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at 10.5 A resolution | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (34-MER), ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
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6WGC
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![BU of 6wgc by Molmil](/molmil-images/mine/6wgc) | Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | Descriptor: | Cell division control protein 6, DNA (41-MER), DNA replication licensing factor MCM3, ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
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3RCZ
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![BU of 3rcz by Molmil](/molmil-images/mine/3rcz) | Rad60 SLD2 Ubc9 Complex | Descriptor: | DNA repair protein rad60, SUMO-conjugating enzyme ubc9 | Authors: | Perry, J.J.P, Arvai, A.S, Tainer, J.A. | Deposit date: | 2011-03-31 | Release date: | 2011-04-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes. Mol.Cell.Biol., 31, 2011
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7K01
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![BU of 7k01 by Molmil](/molmil-images/mine/7k01) | Structure of TFIIH in TFIIH/Rad4-Rad23-Rad33 DNA opening complex | Descriptor: | DNA repair helicase RAD25, DNA repair helicase RAD3, General transcription and DNA repair factor IIH subunit SSL1, ... | Authors: | van Eeuwen, T, Min, J.H, Murakami, K. | Deposit date: | 2020-09-02 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair. Nat Commun, 12, 2021
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5NP7
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![BU of 5np7 by Molmil](/molmil-images/mine/5np7) | |
4M6F
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![BU of 4m6f by Molmil](/molmil-images/mine/4m6f) | |
3SZQ
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![BU of 3szq by Molmil](/molmil-images/mine/3szq) | Structure of an S. pombe APTX/DNA/AMP/Zn complex | Descriptor: | 5'-D(*CP*CP*CP*TP*G)-3', 5'-D(*TP*AP*TP*CP*GP*GP*AP*AP*TP*CP*AP*GP*GP*G)-3', ADENOSINE MONOPHOSPHATE, ... | Authors: | Tumbale, P, Krahn, J, Williams, R.S. | Deposit date: | 2011-07-19 | Release date: | 2011-10-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.353 Å) | Cite: | Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease. Nat.Struct.Mol.Biol., 18, 2011
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2D8M
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![BU of 2d8m by Molmil](/molmil-images/mine/2d8m) | |
3Q4F
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![BU of 3q4f by Molmil](/molmil-images/mine/3q4f) | Crystal structure of xrcc4/xlf-cernunnos complex | Descriptor: | DNA repair protein XRCC4, Non-homologous end-joining factor 1 | Authors: | Ropars, V, Legrand, P, Charbonnier, J.B. | Deposit date: | 2010-12-23 | Release date: | 2011-08-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (5.5 Å) | Cite: | Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining. Proc.Natl.Acad.Sci.USA, 108, 2011
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6WJF
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![BU of 6wjf by Molmil](/molmil-images/mine/6wjf) | PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma | Descriptor: | DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit | Authors: | Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S. | Deposit date: | 2020-04-13 | Release date: | 2020-12-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (7.5 Å) | Cite: | Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. Plos Biol., 18, 2020
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6WJG
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![BU of 6wjg by Molmil](/molmil-images/mine/6wjg) | PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma | Descriptor: | DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha fusion, cAMP-dependent protein kinase type II-beta regulatory subunit | Authors: | Lu, T.-W, Aoto, P.C, Weng, J.-H, Nielsen, C, Cash, J.N, Hall, J, Zhang, P, Simon, S.M, Cianfrocco, M.A, Taylor, S.S. | Deposit date: | 2020-04-13 | Release date: | 2020-12-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Structural analyses of the PKA RII beta holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. Plos Biol., 18, 2020
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