8W8D
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5ELY
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![BU of 5ely by Molmil](/molmil-images/mine/5ely) | X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a hydroxamate inhibitor JHU242 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(2~{R})-2-carboxy-5-(oxidanylamino)-5-oxidanylidene-pentyl]benzoic acid, ... | Authors: | Barinka, C, Novakova, Z, Pavlicek, J. | Deposit date: | 2015-11-05 | Release date: | 2016-04-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity. J.Med.Chem., 59, 2016
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8WPZ
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7R85
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![BU of 7r85 by Molmil](/molmil-images/mine/7r85) | Structure of mouse Bai1 (ADGRB1) TSR3 domain | Descriptor: | Vasculostatin-120, alpha-D-mannopyranose, beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | Deposit date: | 2021-06-26 | Release date: | 2021-11-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. Cell, 184, 2021
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5GKH
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![BU of 5gkh by Molmil](/molmil-images/mine/5gkh) | Structure of EndoMS-dsDNA2 complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*AP*CP*GP*GP*CP*AP*CP*TP*TP*GP*GP*CP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*GP*CP*CP*AP*GP*GP*TP*GP*CP*CP*GP*T)-3'), ... | Authors: | Nakae, S, Hijikata, A, Tsuji, T, Yonezawa, K, Kouyama, K, Mayanagi, K, Ishino, S, Ishino, Y, Shirai, T. | Deposit date: | 2016-07-04 | Release date: | 2016-11-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of the EndoMS-DNA Complex as Mismatch Restriction Endonuclease Structure, 24, 2016
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4IDB
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![BU of 4idb by Molmil](/molmil-images/mine/4idb) | Structure of the Fragaria x ananassa enone oxidoreductase in complex with NADP+ | Descriptor: | 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Ripening-induced protein, ... | Authors: | Schiefner, A, Skerra, A. | Deposit date: | 2012-12-12 | Release date: | 2013-04-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone J.Biol.Chem., 288, 2013
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4NAT
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![BU of 4nat by Molmil](/molmil-images/mine/4nat) | Inhibitors of 4-Phosphopanthetheine Adenylyltransferase | Descriptor: | (1R,2R)-N-(3,4-dichlorobenzyl)-2-(4,6-dimethoxypyrimidin-2-yl)cyclohexanecarboxamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Lahiri, S.D. | Deposit date: | 2013-10-22 | Release date: | 2014-03-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Discovery of Inhibitors of 4'-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy. Antimicrob.Agents Chemother., 57, 2013
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4IE6
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2X23
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![BU of 2x23 by Molmil](/molmil-images/mine/2x23) | crystal structure of M. tuberculosis InhA inhibited by PT70 | Descriptor: | 5-HEXYL-2-(2-METHYLPHENOXY)PHENOL, DIMETHYL SULFOXIDE, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], ... | Authors: | Luckner, S.R, Liu, N, am Ende, C.W, Tonge, P.J, Kisker, C. | Deposit date: | 2010-01-10 | Release date: | 2010-03-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.807 Å) | Cite: | A Slow, Tight Binding Inhibitor of Inha, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis. J.Biol.Chem., 285, 2010
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7K3R
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![BU of 7k3r by Molmil](/molmil-images/mine/7k3r) | Cryo-EM structure of AIM2-PYD filament | Descriptor: | Interferon-inducible protein AIM2 | Authors: | Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H. | Deposit date: | 2020-09-12 | Release date: | 2021-05-26 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome. Nat Commun, 12, 2021
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8VSP
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![BU of 8vsp by Molmil](/molmil-images/mine/8vsp) | Cryo-EM structure of human invariant chain in complex with HLA-DQ | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, ... | Authors: | Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. | Deposit date: | 2024-01-24 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structural insights into human MHC-II association with invariant chain. Proc.Natl.Acad.Sci.USA, 121, 2024
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2CMD
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2CAR
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![BU of 2car by Molmil](/molmil-images/mine/2car) | Crystal Structure Of Human Inosine Triphosphatase | Descriptor: | INOSINE TRIPHOSPHATE PYROPHOSPHATASE | Authors: | Stenmark, P, Kursula, P, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Hogbom, M, Holmberg Schiavone, L, Kotenyova, T, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Schuler, H, Sundstrom, M, Thorsell, A.G, van den Berg, S, Weigelt, J, Nordlund, P. | Deposit date: | 2005-12-22 | Release date: | 2006-01-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Crystal Structure of Human Inosine Triphosphatase. Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T. J.Biol.Chem., 282, 2007
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3AUJ
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![BU of 3auj by Molmil](/molmil-images/mine/3auj) | Structure of diol dehydratase complexed with glycerol | Descriptor: | CALCIUM ION, COBALAMIN, Diol dehydrase alpha subunit, ... | Authors: | Yamanishi, M, Kinoshita, K, Fukuoka, M, Shibata, T, Tobimatsu, T, Toraya, T. | Deposit date: | 2011-02-07 | Release date: | 2012-02-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Redesign of coenzyme B(12) dependent diol dehydratase to be resistant to the mechanism-based inactivation by glycerol and act on longer chain 1,2-diols Febs J., 279, 2012
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4LGH
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5DAZ
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7KCJ
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5DB3
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![BU of 5db3 by Molmil](/molmil-images/mine/5db3) | Menin in complex with MI-574 | Descriptor: | 6-methoxy-4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | Authors: | Pollock, J, Borkin, D, Cierpicki, T, Grembecka, J. | Deposit date: | 2015-08-20 | Release date: | 2016-03-30 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J.Med.Chem., 59, 2016
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4LHC
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![BU of 4lhc by Molmil](/molmil-images/mine/4lhc) | Crystal structure of Synechocystis sp. PCC 6803 glycine decarboxylase (P-protein), holo form with pyridoxal-5'-phosphate and glycine | Descriptor: | 1,2-ETHANEDIOL, BICARBONATE ION, BICINE, ... | Authors: | Hasse, D, Andersson, E, Carlsson, G, Masloboy, A, Hagemann, M, Bauwe, H, Andersson, I. | Deposit date: | 2013-07-01 | Release date: | 2013-10-16 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.899 Å) | Cite: | Structure of the Homodimeric Glycine Decarboxylase P-protein from Synechocystis sp. PCC 6803 Suggests a Mechanism for Redox Regulation. J.Biol.Chem., 288, 2013
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4LIW
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7JSR
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![BU of 7jsr by Molmil](/molmil-images/mine/7jsr) | Crystal structure of the large glutamate dehydrogenase composed of 180 kDa subunits from Mycobacterium smegmatis | Descriptor: | NAD-specific glutamate dehydrogenase | Authors: | Lazaro, M, Melero, R, Huet, C, Lopez-Alonso, J.P, Delgado, S, Dodu, A, Bruch, E.M, Abriata, L.A, Alzari, P.M, Valle, M, Lisa, M.N. | Deposit date: | 2020-08-15 | Release date: | 2021-06-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (6.27 Å) | Cite: | 3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme. Commun Biol, 4, 2021
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7RHE
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5GM7
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![BU of 5gm7 by Molmil](/molmil-images/mine/5gm7) | Crystal structure of Ribosome inactivating protein from Momordica balsamina at 1.78 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Ribosome inactivating protein | Authors: | Singh, B, Singh, P.K, Pandey, S.N, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2016-07-13 | Release date: | 2016-07-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Crystal structure of Ribosome inactivating protein from Momordica balsamina at 1.78 Angstrom resolution To Be Published
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8VRW
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![BU of 8vrw by Molmil](/molmil-images/mine/8vrw) | Cryo-EM structure of human invariant chain in complex with HLA-DR15 | Descriptor: | HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DR alpha chain, ... | Authors: | Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. | Deposit date: | 2024-01-22 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Structural insights into human MHC-II association with invariant chain. Proc.Natl.Acad.Sci.USA, 121, 2024
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7JOF
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![BU of 7jof by Molmil](/molmil-images/mine/7jof) | Calcium-bound C2A Domain from Human Dysferlin | Descriptor: | CALCIUM ION, Isoform 6 of Dysferlin | Authors: | Tadayon, R, Wang, Y, Santamaria, L, Mercier, P, Forristal, C, Shaw, G.S. | Deposit date: | 2020-08-06 | Release date: | 2021-06-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner. Biochem.J., 478, 2021
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