2X23

crystal structure of M. tuberculosis InhA inhibited by PT70

Summary for 2X23

Entry DOI	10.2210/pdb2x23/pdb
Related	1BVR 1ENY 1ENZ 1P44 1P45 1ZID 2AQI 2AQK 2B35 2B36 2B37 2H7I 2H7M 2H7P 2NV6 2X22
Descriptor	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 5-HEXYL-2-(2-METHYLPHENOXY)PHENOL, ... (5 entities in total)
Functional Keywords	fatty acid biosynthesis, oxidoreductase, lipid synthesis, antibiotic resistance
Biological source	MYCOBACTERIUM TUBERCULOSIS
Total number of polymer chains	4
Total formula weight	118088.53
Authors	Luckner, S.R.,Liu, N.,am Ende, C.W.,Tonge, P.J.,Kisker, C. (deposition date: 2010-01-10, release date: 2010-03-02, Last modification date: 2011-07-13)
Primary citation	Luckner, S.R.,Liu, N.,Am Ende, C.W.,Tonge, P.J.,Kisker, C. A Slow, Tight Binding Inhibitor of Inha, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis. J.Biol.Chem., 285:14330-, 2010 Cited by PubMed: 20200152 DOI: 10.1074/JBC.M109.090373 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.807 Å)

Structure validation