5DB3

Menin in complex with MI-574

Summary for 5DB3

Entry DOI	10.2210/pdb5db3/pdb
Related	5DB0 5DB1 5DB2
Descriptor	Menin, DIMETHYL SULFOXIDE, TETRAETHYLENE GLYCOL, ... (7 entities in total)
Functional Keywords	protein binding, protein binding-inhibitor complex, protein binding/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	56278.10
Authors	Pollock, J.,Borkin, D.,Cierpicki, T.,Grembecka, J. (deposition date: 2015-08-20, release date: 2016-03-30, Last modification date: 2024-03-06)
Primary citation	Borkin, D.,Pollock, J.,Kempinska, K.,Purohit, T.,Li, X.,Wen, B.,Zhao, T.,Miao, H.,Shukla, S.,He, M.,Sun, D.,Cierpicki, T.,Grembecka, J. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J.Med.Chem., 59:892-913, 2016 Cited by PubMed: 26744767 DOI: 10.1021/acs.jmedchem.5b01305 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation