5DB3

Menin in complex with MI-574

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue DMS A 601

Chain	Residue
A	SER155
A	58Q610
A	HOH946
A	HOH994

---

site_id	AC2
Number of Residues	6
Details	binding site for residue PG4 A 602

Chain	Residue
A	HOH858
A	LEU75
A	THR76
A	PHE365
A	HOH704
A	HOH800

---

site_id	AC3
Number of Residues	1
Details	binding site for residue SO4 A 603

Chain	Residue
A	ARG14

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 604

Chain	Residue
A	ARG332
A	VAL334
A	ARG335
A	ALA403
A	HOH919
A	HOH965

---

site_id	AC5
Number of Residues	1
Details	binding site for residue SO4 A 605

Chain	Residue
A	ARG446

---

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 A 606

Chain	Residue
A	TYR133
A	PHE134
A	ARG137

---

site_id	AC7
Number of Residues	4
Details	binding site for residue DMS A 607

Chain	Residue
A	PHE43
A	PHE47
A	GLY386
A	HOH820

---

site_id	AC8
Number of Residues	6
Details	binding site for residue DMS A 608

Chain	Residue
A	VAL185
A	GLY190
A	GLU191
A	TYR227
A	ARG229
A	SER583

---

site_id	AC9
Number of Residues	3
Details	binding site for residue PEG A 609

Chain	Residue
A	TRP126
A	SER130
A	LYS135

---

site_id	AD1
Number of Residues	21
Details	binding site for residue 58Q A 610

Chain	Residue
A	SER155
A	LEU177
A	SER178
A	ASP180
A	HIS181
A	ALA182
A	PHE238
A	TYR276
A	MET278
A	MET322
A	TYR323
A	GLY326
A	TRP341
A	GLU363
A	GLU366
A	VAL371
A	DMS601
A	HOH813
A	HOH892
A	HOH909
A	HOH983

---

site_id	AD2
Number of Residues	6
Details	binding site for residue PG4 A 611

Chain	Residue
A	TYR268
A	ASP269
A	GLU274
A	LYS304
A	HOH748
A	HOH764

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