4NAT

Inhibitors of 4-Phosphopanthetheine Adenylyltransferase

Summary for 4NAT

• Entry DOI: 10.2210/pdb4nat/pdb
• Related: 4NAH 4NAU
• Descriptor: Phosphopantetheine adenylyltransferase, (1R,2R)-N-(3,4-dichlorobenzyl)-2-(4,6-dimethoxypyrimidin-2-yl)cyclohexanecarboxamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (5 entities in total)
• Functional Keywords: coad, panthetheine, phosphopanthetheine adenylyltransferase, coabc, cytosolic, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Staphylococcus aureus
• Cellular location: Cytoplasm (By similarity): P63820
• Total number of polymer chains: 3
• Total formula weight: 58222.64

Authors

Lahiri, S.D. (deposition date: 2013-10-22, release date: 2014-03-12, Last modification date: 2024-02-28)

• Primary citation: de Jonge, B.L.,Walkup, G.K.,Lahiri, S.D.,Huynh, H.,Neckermann, G.,Utley, L.,Nash, T.J.,Brock, J.,San Martin, M.,Kutschke, A.,Johnstone, M.,Laganas, V.,Hajec, L.,Gu, R.F.,Ni, H.,Chen, B.,Hutchings, K.,Holt, E.,McKinney, D.,Gao, N.,Livchak, S.,Thresher, J.; Discovery of Inhibitors of 4'-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy.; Antimicrob.Agents Chemother., 57:6005-6015, 2013; PubMed: 24041904; DOI: 10.1128/AAC.01661-13

Experimental method

X-RAY DIFFRACTION (1.72 Å)