PDB: 13252 resultsInfo pagesStatus searchChemie searchBIRD

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4J2R	Middle domain of influenza A virus RNA-dependent polymerase PB2 Descriptor: Polymerase basic protein 2 Authors: Qiu, H, Tsurumura, T, Tsumori, Y, Hatakeyama, D, Kuzuhara, T, Tsuge, H. Deposit date: 2013-02-05 Release date: 2014-02-05 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus ACTA CRYSTALLOGR.,SECT.F, 70, 2014
5EF9	Structure of Influenza B Lee PB2 cap-binding domain Descriptor: Polymerase basic protein 2 Authors: Ma, X, Shia, S. Deposit date: 2015-10-23 Release date: 2015-11-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit. J.Biol.Chem., 291, 2016
3T5J	Ternary complex of HNE Adduct modified DNA (5'-TXG-3' vs 13-mer) with Dpo4 and incoming dDTP Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*(HN1)P*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ... Authors: Banerjee, S, Christov, P.P, Kozekova, A, Rizzo, C.J, Stone, M.P. Deposit date: 2011-07-27 Release date: 2012-02-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV. Chem.Res.Toxicol., 25, 2012
3T5K	Ternary complex of HNE Adduct modified DNA (5'-TXG-3' vs 14-mer) with Dpo4 and incoming dDTP Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*(HN0)P*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ... Authors: Banerjee, S, Christov, P.P, Kozekova, A, Rizzo, C.J, Stone, M.P. Deposit date: 2011-07-27 Release date: 2012-02-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV. Chem.Res.Toxicol., 25, 2012
3T5L	Ternary complex of HNE Adduct modified DNA (5'-CXG-3' vs 14-mer) with Dpo4 and incoming dDGT Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*CP*(HN0)P*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ... Authors: Banerjee, S, Christov, P.P, Kozekova, A, Rizzo, C.J, Stone, M.P. Deposit date: 2011-07-27 Release date: 2012-02-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV. Chem.Res.Toxicol., 25, 2012
3T5H	Ternary complex of HNE Adduct modified DNA (5'-CXG-3' vs 13-mer) with Dpo4 and incoming dDGT Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*CP*(HN1)P*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ... Authors: Banerjee, S, Christov, P.P, Kozekova, A, Rizzo, C.J, Stone, M.P. Deposit date: 2011-07-27 Release date: 2012-02-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV. Chem.Res.Toxicol., 25, 2012
7LYG	Zika virus RNA promoter stem-loop A with tRNA-scaffold Descriptor: RNA promoter stem-loop A fused with tRNA Authors: Lee, E.H, Choi, K.H. Deposit date: 2021-03-06 Release date: 2021-05-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.804 Å) Cite: Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase. Nat Commun, 12, 2021
6N4O	Human Argonaute2-miR-122 bound to a seed and supplementary paired target Descriptor: Protein argonaute-2, RNA (5'-R(*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') Authors: Sheu-Gruttadauria, J, MacRae, I.J. Deposit date: 2018-11-19 Release date: 2019-05-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.899 Å) Cite: Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2. Embo J., 38, 2019
5IZH	Lassa virus L protein cap-snatching endonuclease. apo form Descriptor: RNA-directed RNA polymerase L Authors: Reguera, J, Cusack, S. Deposit date: 2016-03-25 Release date: 2016-06-29 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases. Plos Pathog., 12, 2016
4WBZ	tRNA-processing enzyme (apo form 2) Descriptor: Poly A polymerase Authors: Yamashita, S, Tomtia, K. Deposit date: 2014-09-04 Release date: 2015-04-15 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Measurement of Acceptor-T Psi C Helix Length of tRNA for Terminal A76-Addition by A-Adding Enzyme. Structure, 23, 2015
2W9A	Ternary complex of Dpo4 bound to N2,N2-dimethyl-deoxyguanosine modified DNA with incoming dGTP Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*DOC)-3', 5'-D(*TP*CP*AP*CP*O2GP*GP*AP*AP*TP*CP *CP*TP*TP*CP*CP*CP*CP*C)-3', ... Authors: Eoff, R.L, Zhang, H, Kosekov, I.D, Rizzo, C.J, Egli, M, Guengerich, F.P. Deposit date: 2009-01-22 Release date: 2009-05-12 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure-Function Relationships in Miscoding by Sulfolobus Solfataricus DNA Polymerase Dpo4: Guanine N2,N2-Dimethyl Substitution Produces Inactive and Miscoding Polymerase Complexes. J.Biol.Chem., 284, 2009
2W9C	Ternary complex of Dpo4 bound to N2,N2-dimethyl-deoxyguanosine modified DNA with incoming dTTP Descriptor: 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*DOCP)-3', 5'-D(*TP*CP*AP*CP*O2GP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', DNA POLYMERASE IV, ... Authors: Eoff, R.L, Zhang, H, Kosekov, I.D, Rizzo, C.J, Egli, M, Guengerich, F.P. Deposit date: 2009-01-22 Release date: 2009-05-12 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure-Function Relationships in Miscoding by Sulfolobus Solfataricus DNA Polymerase Dpo4: Guanine N2,N2-Dimethyl Substitution Produces Inactive and Miscoding Polymerase Complexes. J.Biol.Chem., 284, 2009
7Q2J	Quaternary Complex of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC Homer Descriptor: Elongin-B, Elongin-C, N-[5-[4-[[5-[[(2S)-3,3-dimethyl-1-[(2S,4R)-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-5-oxidanylidene-pentyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanylidene-4-(trifluoromethyl)-1H-pyridine-3-carboxamide, ... Authors: Kraemer, A, Doelle, A, Schwalm, M.P, Adhikari, B, Wolf, E, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2021-10-25 Release date: 2021-11-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30, 2023
8AS6	Structure of the SFTSV L protein bound to 5' cRNA hook [5' HOOK] Descriptor: RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*C)-3'), RNA-dependent RNA-polymerase L protein Authors: Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. Deposit date: 2022-08-18 Release date: 2023-01-18 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
5EWG	Ternary complex of human DNA polymerase eta inserting rATP opposite an 8-Oxodeoxyguanosine Lesion Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Su, Y, Egli, M, Guengerich, F.P. Deposit date: 2015-11-20 Release date: 2016-01-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta. J.Biol.Chem., 291, 2016
5EWF	Ternary complex of human DNA polymerase eta inserting rCTP opposite an 8-Oxodeoxyguanosine Lesion Descriptor: CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Su, Y, Egli, M, Guengerich, F.P. Deposit date: 2015-11-20 Release date: 2016-01-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.782 Å) Cite: Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta. J.Biol.Chem., 291, 2016
5EWE	Ternary complex of human DNA polymerase eta inserting rCTP opposite template G Descriptor: CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Su, Y, Egli, M, Guengerich, F.P. Deposit date: 2015-11-20 Release date: 2016-01-13 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta. J.Biol.Chem., 291, 2016
3H4D	Ternary complex of human DNA polymerase iota with template U/T and incoming dGTP Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC)), 5'-D(*TP*(BRU)P*GP*GP*GP*TP*CP*CP*T), ... Authors: Jain, R, Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. Deposit date: 2009-04-18 Release date: 2009-07-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Replication across template T/U by human DNA polymerase-iota. Structure, 17, 2009
3H4B	Ternary complex of human DNA polymerase iota with template U/T and incoming dATP Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*(BRU)P*GP*GP*GP*TP*CP*CP*T)-3', ... Authors: Jain, R, Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. Deposit date: 2009-04-18 Release date: 2009-07-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Replication across template T/U by human DNA polymerase-iota. Structure, 17, 2009
3ISD	Ternary complex of human DNA polymerase beta with an abasic site (THF): DAPCPP mismatch Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, 5'-D(*CP*CP*GP*AP*CP*(3DR)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', ... Authors: Beard, W.A, Shock, D.D, Batra, V.K, Pedersen, L.C, Wilson, S.H. Deposit date: 2009-08-25 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". J.Biol.Chem., 284, 2009
7KI3	Human Argonaute2:miR-122 bound to the HCV genotype 1a site-1 RNA Descriptor: BARIUM ION, HCV genotype 1a miR-122 site-1, Protein argonaute-2, ... Authors: Gebert, L.F.R, MacRae, I.J. Deposit date: 2020-10-22 Release date: 2021-10-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3 Å) Cite: A structured RNA motif locks Argonaute2:miR-122 onto the 5' end of the HCV genome. Nat Commun, 12, 2021
4JWM	Ternary complex of D256E mutant of DNA Polymerase Beta Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... Authors: Batra, V.K, Perera, L, Ping, L, Shock, D.D, Beard, W.A, Pedersen, L.C, Pedersen, L.G, Wilson, S.H. Deposit date: 2013-03-27 Release date: 2013-06-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Amino Acid Substitution in the Active Site of DNA Polymerase beta Explains the Energy Barrier of the Nucleotidyl Transfer Reaction. J.Am.Chem.Soc., 135, 2013
3WI0	P453H/I471T mutant of PB2 middle domain from influenza virus A/Puerto Rico/8/34(H1N1) Descriptor: Polymerase basic protein 2 Authors: Tsurumura, T, Yoshida, T, Tsuge, H. Deposit date: 2013-09-04 Release date: 2013-12-18 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.998 Å) Cite: Conformational Polymorphism of m7GTP in Crystal Structure of the PB2 Middle Domain from Human Influenza A Virus Plos One, 8, 2013
4L1P	Crystal Structure of Human Rtf1 Plus3 domain Descriptor: GLYCEROL, RNA polymerase-associated protein RTF1 homolog Authors: Wier, A.D, Heroux, A, VanDemark, A.P. Deposit date: 2013-06-03 Release date: 2013-10-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin. Proc.Natl.Acad.Sci.USA, 110, 2013
4L1U	Crystal Structure of Human Rtf1 Plus3 Domain in Complex with Spt5 CTR Phosphopeptide Descriptor: GLYCEROL, RNA polymerase-associated protein RTF1 homolog, SULFATE ION, ... Authors: Wier, A.D, Heroux, A, VanDemark, A.P. Deposit date: 2013-06-03 Release date: 2013-10-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.424 Å) Cite: Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin. Proc.Natl.Acad.Sci.USA, 110, 2013

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