4JWM

Ternary complex of D256E mutant of DNA Polymerase Beta

Summary for 4JWM

• Entry DOI: 10.2210/pdb4jwm/pdb
• Related: 4JWN
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... (9 entities in total)
• Functional Keywords: nucleotidyl transfer, dntp, non-hydrolyzable analog, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 48409.46

Authors

Batra, V.K.,Perera, L.,Ping, L.,Shock, D.D.,Beard, W.A.,Pedersen, L.C.,Pedersen, L.G.,Wilson, S.H. (deposition date: 2013-03-27, release date: 2013-06-26, Last modification date: 2023-09-20)

• Primary citation: Batra, V.K.,Perera, L.,Lin, P.,Shock, D.D.,Beard, W.A.,Pedersen, L.C.,Pedersen, L.G.,Wilson, S.H.; Amino Acid Substitution in the Active Site of DNA Polymerase beta Explains the Energy Barrier of the Nucleotidyl Transfer Reaction.; J.Am.Chem.Soc., 135:8078-8088, 2013; PubMed: 23647366; DOI: 10.1021/ja403842j

Experimental method

X-RAY DIFFRACTION (2 Å)