PDB: 47720 resultsInfo pagesStatus searchChemie searchBIRD

---

6T5F	Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-195 Descriptor: 14-3-3 protein sigma, StARD1 peptide Authors: Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. Deposit date: 2019-10-16 Release date: 2020-11-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.63 Å) Cite: Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. Febs J., 287, 2020
6T5H	Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-57 Descriptor: 14-3-3 protein sigma,Steroidogenic acute regulatory protein, mitochondrial, IMIDAZOLE, ... Authors: Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. Deposit date: 2019-10-16 Release date: 2020-11-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. Febs J., 287, 2020
6TLG	Ligand-free state of human 14-3-3 sigma isoform Descriptor: 14-3-3 protein sigma, DI(HYDROXYETHYL)ETHER, SULFATE ION Authors: Tassone, G, Pozzi, C, Mangani, S. Deposit date: 2019-12-02 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction. Acs Chem.Biol., 15, 2020
7NPG	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 22 Descriptor: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-26 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
3NKX	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome Descriptor: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase Authors: Schumacher, B, Weyand, M, Ottmann, C. Deposit date: 2010-06-21 Release date: 2010-09-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling Mol.Cell.Biol., 30, 2010
8BYO	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2023-01-18 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYE	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075313) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclobutane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4G	Small molecule amidine soak in 14-3-3/ERa (AZ132) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2023-01-03 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.46 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYB	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074398) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX4	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074392) Descriptor: 14-3-3 protein sigma, 2-[3,4-bis(chloranyl)phenoxy]-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-07 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXO	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075287) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4,4-bis(fluoranyl)-1-phenoxy-cyclohexane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-09 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWZ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074393) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-ethanoylphenoxy)-2-methyl-propanamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-07 Release date: 2023-08-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXQ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075296) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-phenoxy-cyclohexane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-09 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYF	fragment-linked stabilizer for ERa - 14-3-3 interaction (1047455) Descriptor: 14-3-3 protein sigma, PHE-PRO-ALA-TPO-VAL, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-chloranylphenoxy)-2-methyl-propanamide Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BY9	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075292) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)-4,4-bis(fluoranyl)cyclohexane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZ0	single soak stabilizer for ERa - 14-3-3 interaction (AZ275) Descriptor: 14-3-3 protein sigma, 4-ethoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZA	single soak stabilizer for ERa - 14-3-3 interaction (AZ555) Descriptor: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.25 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXI	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-08 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYD	fragment-linked stabilizer for ERa - 14-3-3 interactions (1075288) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclopentane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYC	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075316) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C0K	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-17 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX3	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074372) Descriptor: 14-3-3 protein sigma, 2-(4-bromanylphenoxy)-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-07 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXN	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074399) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-phenoxy-oxane-4-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-09 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYY	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074395) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-[(4-chlorophenyl)amino]-2-methyl-propanamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4F	Small molecule amidine soak in 14-3-3/ERa (AZ037) Descriptor: 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2023-01-03 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023

<3456789101112131415161718>