6QVC
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2R9H
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4FG6
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![BU of 4fg6 by Molmil](/molmil-images/mine/4fg6) | Structure of EcCLC E148A mutant in Glutamate | Descriptor: | Fab fragment (Heavy chain), Fab fragment (Light chain), H(+)/Cl(-) exchange transporter ClcA | Authors: | Feng, L, MacKinnon, R. | Deposit date: | 2012-06-04 | Release date: | 2012-07-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.019 Å) | Cite: | Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters. Proc.Natl.Acad.Sci.USA, 109, 2012
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6LSC
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6V2J
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![BU of 6v2j by Molmil](/molmil-images/mine/6v2j) | Crystal structure of ClC-ec1 triple mutant (E113Q, E148Q, E203Q) | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Maduke, M, Mathews, I.I, Chavan, T.S. | Deposit date: | 2019-11-24 | Release date: | 2020-05-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl - /H + transport cycle. Elife, 9, 2020
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3Q17
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![BU of 3q17 by Molmil](/molmil-images/mine/3q17) | Structure of a slow CLC Cl-/H+ antiporter from a cyanobacterium in Bromide | Descriptor: | BROMIDE ION, Sll0855 protein | Authors: | Jayaram, H, Robertson, J.L, Fang, W, Williams, C, Miller, C. | Deposit date: | 2010-12-16 | Release date: | 2011-01-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structure of a Slow CLC Cl(-)/H(+) Antiporter from a Cyanobacterium. Biochemistry, 50, 2011
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8GQU
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![BU of 8gqu by Molmil](/molmil-images/mine/8gqu) | AK-42 inhibitor binding human ClC-2 TMD | Descriptor: | 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, Chloride channel protein 2 | Authors: | Wang, L. | Deposit date: | 2022-08-30 | Release date: | 2023-07-05 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42. Nat Commun, 14, 2023
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5HD8
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6AD8
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![BU of 6ad8 by Molmil](/molmil-images/mine/6ad8) | Crystal structure of the E148D mutant CLC-ec1 in 50 mM bromide | Descriptor: | BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | Authors: | Lim, H.-H, Park, K. | Deposit date: | 2018-07-31 | Release date: | 2019-08-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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4ENE
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![BU of 4ene by Molmil](/molmil-images/mine/4ene) | Structure of the N- and C-terminal trimmed ClC-ec1 Cl-/H+ antiporter and Fab Complex | Descriptor: | CHLORIDE ION, DECYL-BETA-D-MALTOPYRANOSIDE, H(+)/Cl(-) exchange transporter ClcA, ... | Authors: | Lim, H.H, Shane, T, Miller, C. | Deposit date: | 2012-04-13 | Release date: | 2012-12-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Intracellular proton access in a cl(-)/h(+) antiporter. Plos Biol., 10, 2012
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7CVT
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![BU of 7cvt by Molmil](/molmil-images/mine/7cvt) | Crystal structure of the C85A/L194A/H234C mutant CLC-ec1 with Fab fragment | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | Authors: | Park, K, Mersch, K, Robertson, J, Lim, H.-H. | Deposit date: | 2020-08-27 | Release date: | 2021-09-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface. J.Mol.Biol., 433, 2021
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7CVS
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![BU of 7cvs by Molmil](/molmil-images/mine/7cvs) | Crystal structure of the C85A/L194A mutant CLC-ec1 with Fab fragment | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | Authors: | Park, K, Mersch, K, Robertson, J, Lim, H.-H. | Deposit date: | 2020-08-27 | Release date: | 2021-09-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface. J.Mol.Biol., 433, 2021
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7N8P
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![BU of 7n8p by Molmil](/molmil-images/mine/7n8p) | CLC-ec1 at pH 4.5 100mM Cl Swap | Descriptor: | H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Boudker, O, Accardi, A. | Deposit date: | 2021-06-15 | Release date: | 2022-11-16 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Structural basis of common gate activation in CLC transporters To Be Published
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7N9W
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![BU of 7n9w by Molmil](/molmil-images/mine/7n9w) | CLC-ec1 pH 4.5 100mM Cl Twist1 | Descriptor: | H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Boudker, O, Accardi, A. | Deposit date: | 2021-06-18 | Release date: | 2022-11-16 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.16 Å) | Cite: | Structural basis of common gate activation in CLC transporters To Be Published
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1KPK
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![BU of 1kpk by Molmil](/molmil-images/mine/1kpk) | Crystal Structure of the ClC Chloride Channel from E. coli | Descriptor: | putative channel transporter | Authors: | Dutzler, R, Campbell, E.B, Cadene, M, Chait, B.T, MacKinnon, R. | Deposit date: | 2001-12-31 | Release date: | 2002-01-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of
anion selectivity. Nature, 415, 2002
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1KPL
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![BU of 1kpl by Molmil](/molmil-images/mine/1kpl) | Crystal Structure of the ClC Chloride Channel from S. typhimurium | Descriptor: | CHLORIDE ION, N-OCTANE, PENTADECANE, ... | Authors: | Dutzler, R, Campbell, E.B, Cadene, M, Chait, B.T, MacKinnon, R. | Deposit date: | 2001-12-31 | Release date: | 2002-01-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of
anion selectivity. Nature, 415, 2002
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3ND0
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![BU of 3nd0 by Molmil](/molmil-images/mine/3nd0) | X-ray crystal structure of a slow cyanobacterial Cl-/H+ antiporter | Descriptor: | CHLORIDE ION, Sll0855 protein | Authors: | Jayaram, H, Robertson, J, Wu, F, Williams, C, Miller, C. | Deposit date: | 2010-06-06 | Release date: | 2011-01-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of a Slow CLC Cl(-)/H(+) Antiporter from a Cyanobacterium. Biochemistry, 50, 2011
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6K5F
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![BU of 6k5f by Molmil](/molmil-images/mine/6k5f) | Crystal structure of the CLC-ec1 deltaNC in presence of 200 mM NaBr | Descriptor: | BROMIDE ION, Fab fragment, heavy chain, ... | Authors: | Park, K, Lim, H.H. | Deposit date: | 2019-05-28 | Release date: | 2019-08-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.203 Å) | Cite: | Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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5TR1
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5TQQ
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3NMO
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6K5D
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7XJA
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![BU of 7xja by Molmil](/molmil-images/mine/7xja) | TMD masked refine map of human ClC-2 | Descriptor: | Chloride channel protein 2 | Authors: | Wang, L. | Deposit date: | 2022-04-15 | Release date: | 2023-05-17 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42 Nat Commun, 14, 2023
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7XF5
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![BU of 7xf5 by Molmil](/molmil-images/mine/7xf5) | Full length human CLC-2 channel in apo state | Descriptor: | Chloride channel protein 2 | Authors: | Wang, L. | Deposit date: | 2022-04-01 | Release date: | 2023-05-03 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42 Nat Commun, 14, 2023
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3DET
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![BU of 3det by Molmil](/molmil-images/mine/3det) | Structure of the E148A, Y445A doubly ungated mutant of E.coli CLC_Ec1, Cl-/H+ antiporter | Descriptor: | Fab fragment, Heavy chain, Light chain, ... | Authors: | Jayaram, H, Accardi, A, Wu, F, Williams, C, Miller, C. | Deposit date: | 2008-06-10 | Release date: | 2008-06-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger Proc.Natl.Acad.Sci.USA, 105, 2008
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