4UUS
| CRYSTAL STRUCTURE OF A UBX-EXD-DNA COMPLEX INCLUDING THE UBDA MOTIF | Descriptor: | 5'-D(*AP*CP*GP*TP*GP*AP*TP*TP*TP*AP*TP*GP*GP*CP*G)-3', 5'-D(*GP*TP*CP*GP*CP*CP*AP*TP*AP*AP*AP*TP*CP*AP*C)-3', HOMEOTIC PROTEIN EXTRADENTICLE, ... | Authors: | Foos, N, Mate, M.J, Ortiz-Lombardia, M. | Deposit date: | 2014-07-31 | Release date: | 2015-02-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | A Flexible Extension of the Drosophila Ultrabithorax Homeodomain Defines a Novel Hox/Pbc Interaction Mode. Structure, 23, 2015
|
|
7U0I
| Structure of LIN28b nucleosome bound 2 OCT4 | Descriptor: | DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | Authors: | Tengfei, L, Guan, R, Bai, Y. | Deposit date: | 2022-02-18 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural mechanism of LIN28B nucleosome targeting by OCT4. Mol.Cell, 83, 2023
|
|
7U0G
| structure of LIN28b nucleosome bound 3 OCT4 | Descriptor: | DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | Authors: | Lian, T, Guan, R, Bai, Y. | Deposit date: | 2022-02-18 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural mechanism of LIN28B nucleosome targeting by OCT4. Mol.Cell, 83, 2023
|
|
3D1N
| Structure of human Brn-5 transcription factor in complex with corticotrophin-releasing hormone gene promoter | Descriptor: | 5'-D(*DAP*DGP*DCP*DAP*DTP*DAP*DAP*DAP*DTP*DAP*DAP*DTP*DAP*DA)-3', 5'-D(*DTP*DTP*DAP*DTP*DTP*DAP*DTP*DTP*DTP*DAP*DTP*DGP*DCP*DT)-3', POU domain, ... | Authors: | Pereira, J.H, Ha, S.C, Kim, S.-H. | Deposit date: | 2008-05-06 | Release date: | 2009-05-26 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structure of human Brn-5 transcription factor in complex with CRH gene promoter. J.Struct.Biol., 167, 2009
|
|
1S7E
| Solution structure of HNF-6 | Descriptor: | Hepatocyte nuclear factor 6 | Authors: | Liao, X, Sheng, W. | Deposit date: | 2004-01-29 | Release date: | 2004-12-28 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNA. J.Biol.Chem., 279, 2004
|
|
5NO6
| TEAD4-HOXB13 complex bound to DNA | Descriptor: | DNA, Homeobox protein Hox-B13, Transcriptional enhancer factor TEF-3 | Authors: | Morgunova, E, Jolma, A, Yin, Y, Popov, A, Taipale, J. | Deposit date: | 2017-04-11 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | TEAD4-HOXB13 complex bound to DNA To Be Published
|
|
6WC5
| Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex | Descriptor: | Homeobox protein Nkx-2.5, Myocardin enhancer DNA, Myocyte-specific enhancer factor 2B | Authors: | Chen, L, Lei, X. | Deposit date: | 2020-03-29 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J.Mol.Biol., 432, 2020
|
|
6WC2
| Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex | Descriptor: | Homeobox protein Nkx-2.5, MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A, Myocardin Enhancer DNA | Authors: | Lei, X, Chen, L. | Deposit date: | 2020-03-29 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J.Mol.Biol., 432, 2020
|
|
8SPS
| High resolution structure of ESRRB nucleosome bound OCT4 at site a and site b | Descriptor: | DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | Authors: | Lian, T, Guan, R, Bai, Y. | Deposit date: | 2023-05-03 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural mechanism of LIN28B nucleosome targeting by OCT4. Mol.Cell, 83, 2023
|
|
8SPU
| Structure of ESRRB nucleosome bound OCT4 at site c | Descriptor: | DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | Authors: | Lian, T, Guan, R, Bai, Y. | Deposit date: | 2023-05-03 | Release date: | 2023-06-28 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural mechanism of LIN28B nucleosome targeting by OCT4. Mol.Cell, 83, 2023
|
|
2XSD
| Crystal Structure of the dimeric Oct-6 (Pou3f1) POU domain bound to palindromic MORE DNA | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*AP)-3', 5'-D(*CP*CP*TP*CP*AP*TP*GP*CP*AP*TP*AP)-3', ... | Authors: | Jauch, R, Choo, S.H, Ng, C.K.L, Kolatkar, P.R. | Deposit date: | 2010-09-28 | Release date: | 2010-10-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.049 Å) | Cite: | Crystal Structure of the Dimeric Oct6 (POU3F1) POU Domain Bound to Palindromic More DNA. Proteins, 79, 2011
|
|
5EGO
| HOXB13-MEIS1 heterodimer bound to methylated DNA | Descriptor: | DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... | Authors: | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | Deposit date: | 2015-10-27 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
|
|
5EG0
| HOXB13-MEIS1 heterodimer bound to DNA | Descriptor: | DNA (5'-D(*CP*CP*TP*CP*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... | Authors: | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | Deposit date: | 2015-10-26 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.101 Å) | Cite: | Molecular basis of recognition of two distinct DNA sequences by a single transcription factor To Be Published
|
|
6T90
| OCT4-SOX2-bound nucleosome - SHL-6 | Descriptor: | DNA (146-MER), Green fluorescent protein,POU domain, class 5, ... | Authors: | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | Deposit date: | 2019-10-25 | Release date: | 2020-05-06 | Last modified: | 2020-07-08 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science, 368, 2020
|
|
1HF0
| Crystal structure of the DNA-binding domain of Oct-1 bound to DNA as a dimer | Descriptor: | DNA 5'-D(*CP*AP*CP*AP*TP*TP*TP*GP*AP*AP*AP*GP*GP* CP*AP*AP*AP*TP*GP*GP*AP*G)-3', DNA 5'-D(*CP*TP*CP*CP*AP*TP*TP*TP*GP*CP*CP*TP*TP* TP*CP*AP*AP*AP*TP*GP*TP*G)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1 | Authors: | Remenyi, A, Tomilin, A, Pohl, E, Scholer, H.R, Wilmanns, M. | Deposit date: | 2000-11-27 | Release date: | 2001-11-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Differential Dimer Activities of the Transcription Factor Oct-1 by DNA-Induced Interface Swapping Mol.Cell, 8, 2001
|
|
1GT0
| Crystal structure of a POU/HMG/DNA ternary complex | Descriptor: | 5'-D(*AP*TP*CP*CP*CP*AP*TP*TP*AP*GP* CP*AP*TP*CP*CP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3', 5'-D(*TP*TP*CP*TP*TP*TP*GP*TP*TP*TP* GP*GP*AP* TP*GP*CP*TP*AP*AP*TP*GP*GP*GP*A)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1, ... | Authors: | Remenyi, A, Wilmanns, M. | Deposit date: | 2002-01-09 | Release date: | 2003-01-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of a POU/Hmg/DNA Ternary Complex Suggests Differential Assembly of Oct4 and Sox2 on Two Enhancers Genes Dev., 17, 2003
|
|
8G8E
| Human Oct4 bound to nucleosome with human LIN28B sequence | Descriptor: | LIN28B DNA (32-MER), POU domain, class 5, ... | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | Deposit date: | 2023-02-17 | Release date: | 2023-03-22 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
|
|
8G87
| Human Oct4 bound to nucleosome with human nMatn1 sequence (focused refinement of Oct4 bound region) | Descriptor: | POU domain, class 5, transcription factor 1, ... | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | Deposit date: | 2023-02-17 | Release date: | 2023-03-22 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (8.1 Å) | Cite: | Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
|
|
8G8B
| Nucleosome with human nMatn1 sequence in complex with Human Oct4 | Descriptor: | Histone H2A, Histone H2B, Histone H3, ... | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | Deposit date: | 2023-02-17 | Release date: | 2023-03-22 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
|
|
8G8G
| Interaction of H3 tail in LIN28B nucleosome with Oct4 | Descriptor: | Histone H2A, Histone H2B, Histone H3, ... | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | Deposit date: | 2023-02-17 | Release date: | 2023-03-22 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
|
|
8G88
| Human Oct4 bound to nucleosome with human nMatn1 sequence | Descriptor: | Histone H2A, Histone H2B, Histone H3, ... | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | Deposit date: | 2023-02-17 | Release date: | 2023-03-22 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
|
|
1MH3
| maltose binding-a1 homeodomain protein chimera, crystal form I | Descriptor: | maltose binding-a1 homeodomain protein chimera | Authors: | Ke, A, Wolberger, C. | Deposit date: | 2002-08-19 | Release date: | 2002-09-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera Protein Sci., 12, 2003
|
|
1MH4
| maltose binding-a1 homeodomain protein chimera, crystal form II | Descriptor: | maltose binding-a1 homeodomain protein chimera | Authors: | Ke, A, Wolberger, C. | Deposit date: | 2002-08-19 | Release date: | 2002-09-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera Protein Sci., 12, 2003
|
|
1MNM
| |
1O4X
| |