9FVD
 
 | | Cryo-EM structure of single-layered nucleoprotein-RNA helical assembly from Marburg virus, trimeric repeat unit | | Descriptor: | Nucleoprotein, RNA (5'-R(P*AP*GP*AP*CP*AP*CP*AP*CP*AP*AP*AP*AP*AP*CP*AP*AP*GP*A)-3') | | Authors: | Zinzula, L, Beck, F, Camasta, M, Bohn, S, Liu, C, Morado, D, Bracher, A, Plitzko, J.M, Baumeister, W. | | Deposit date: | 2024-06-26 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus
Nat Commun, 2024
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9IWS
 | | Cryo EM structure of human phosphate channel XPR1 in complex with IP7 | | Descriptor: | (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, Solute carrier family 53 member 1 | | Authors: | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | Deposit date: | 2024-07-25 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
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6XG6
 | | Full-length human mitochondrial Hsp90 (TRAP1) with ADP-BeF3 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Heat shock protein 75 kDa, ... | | Authors: | Liu, Y.X, Wang, F, Agard, D.A. | | Deposit date: | 2020-06-17 | | Release date: | 2020-09-30 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5F0L
 | | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Natural resistance-associated macrophage protein 2, ... | | Authors: | Lucas, M, Gershlick, D, Vidaurrazaga, A, Rojas, A.L, Bonifacino, J.S, Hierro, A. | | Deposit date: | 2015-11-27 | | Release date: | 2016-12-07 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural Mechanism for Cargo Recognition by the Retromer Complex.
Cell, 167, 2016
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9GCU
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9GCS
 | | Rho-ATP-Psu complex II | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Polarity suppression protein, ... | | Authors: | Gjorgjevikj, D, Wahl, M.C, Hilal, T, Loll, B. | | Deposit date: | 2024-08-02 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Rho-ATP-Psu complex II
To Be Published
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7TZO
 | | The apo structure of human mTORC2 complex | | Descriptor: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | | Authors: | Yu, Z, Chen, J, Pearce, D. | | Deposit date: | 2022-02-16 | | Release date: | 2023-01-11 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
J.Biol.Chem., 298, 2022
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9GCT
 | | Rho-ATP-Psu complex II expanded | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Polarity suppression protein, ... | | Authors: | Gjorgjevikj, D, Wahl, M.C, Hilal, T, Loll, B. | | Deposit date: | 2024-08-02 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Rho-ATP-Psu complex II expanded
To Be Published
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8TQ2
 | | Structure of the kinase lobe of human CDK8 kinase module | | Descriptor: | Cyclin-C, Cyclin-dependent kinase 8, Mediator of RNA polymerase II transcription subunit 12, ... | | Authors: | Chen, S.F, Chao, T.C, Kim, H.J, Tang, H.C, Khadka, S, Li, T, Murakami, K, Boyer, T.G, Tsai, K.L. | | Deposit date: | 2023-08-06 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module.
Mol.Cell, 2024
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1WXX
 | | Crystal structure of Tt1595, a putative SAM-dependent methyltransferase from Thermus thermophillus HB8 | | Descriptor: | PHOSPHATE ION, POTASSIUM ION, hypothetical protein TTHA1280 | | Authors: | Pioszak, A.A, Murayama, K, Nakagawa, N, Ebihara, A, Kuramitsu, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-02-02 | | Release date: | 2005-08-02 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structures of a putative RNA 5-methyluridine methyltransferase, Thermus thermophilus TTHA1280, and its complex with S-adenosyl-L-homocysteine.
Acta Crystallogr.,Sect.F, 61, 2005
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8YN3
 | | Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGs | | Descriptor: | CHOLESTEROL, Engineered guanine nucleotide,binding protein G(s) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhang, X, Liu, G, Li, X, Gong, W. | | Deposit date: | 2024-03-10 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.56 Å) | | Cite: | Structural basis of ligand recognition and activation of the histamine receptor family
Nat Commun, 15, 2024
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8K19
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8TQC
 | | Structure of the human CDK8 kinase module | | Descriptor: | Cyclin-C, Cyclin-dependent kinase 8, Mediator of RNA polymerase II transcription subunit 12, ... | | Authors: | Chen, S.F, Chao, T.C, Kim, H.J, Tang, H.C, Khadka, S, Li, T, Murakami, K, Boyer, T.G, Tsai, K.L. | | Deposit date: | 2023-08-06 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module.
Mol.Cell, 2024
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8TRH
 | | The IDRc bound human core Mediator complex | | Descriptor: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | | Authors: | Chen, S.F, Chao, T.C, Kim, H.J, Tang, H.C, Khadka, S, Li, T, Murakami, K, Boyer, T.G, Tsai, K.L. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module.
Mol.Cell, 2024
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8TQW
 | | Structure of human transcriptional Mediator complex | | Descriptor: | Cyclin-C, Cyclin-dependent kinase 8, Mediator of RNA polymerase II transcription subunit 1, ... | | Authors: | Chen, S.F, Chao, T.C, Kim, H.J, Tang, H.C, Khadka, S, Li, T, Murakami, K, Boyer, T.G, Tsai, K.L. | | Deposit date: | 2023-08-08 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (8.2 Å) | | Cite: | Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module.
Mol.Cell, 2024
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8UCP
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5F2B
 | | Expanding Nature's Catalytic Repertoire -Directed Evolution of an Artificial Metalloenzyme for In Vivo Metathesis | | Descriptor: | SULFATE ION, Streptavidin, [1-[4-[[5-[(3~{a}~{S},4~{S},6~{a}~{R})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]methyl]-2,6-dimethyl-phenyl]-3-(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-1-ium-2-yl]-bis(chloranyl)ruthenium | | Authors: | Heinisch, T, Jeschek, M, Reuter, R, Trindler, C, Panke, S, Ward, T.R. | | Deposit date: | 2015-12-01 | | Release date: | 2016-08-31 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Directed evolution of artificial metalloenzymes for in vivo metathesis.
Nature, 537, 2016
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8UCM
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8UCK
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8UCL
 | | Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Tetrabenazine | | Descriptor: | (3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one, COPPER (II) ION, Cytochrome c oxidase subunit 1, ... | | Authors: | Ye, J, Liu, B, Li, W. | | Deposit date: | 2023-09-26 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Tetrabenazine
To Be Published
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8UCN
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8UCJ
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5ILE
 | | H64A sperm whale myoglobin with a Fe-tolyl moiety | | Descriptor: | Myoglobin, SULFATE ION, [3,3'-(7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-diyl-kappa~4~N~21~,N~22~,N~23~,N~24~)di(propanoato)(2-)](3-methylphenyl)iron | | Authors: | Wang, B, Thomas, L.M, Richter-Addo, G.B. | | Deposit date: | 2016-03-03 | | Release date: | 2016-09-21 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Organometallic myoglobins: Formation of Fe-carbon bonds and distal pocket effects on aryl ligand conformations.
J. Inorg. Biochem., 164, 2016
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8VH5
 | | Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 dimer state | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, ... | | Authors: | Zhu, H, Sun, J. | | Deposit date: | 2023-12-30 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.
Nat Commun, 15, 2024
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8VH4
 | | Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 monomer state | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, ... | | Authors: | Zhu, H, Sun, J. | | Deposit date: | 2023-12-30 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.
Nat Commun, 15, 2024
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