8VH5

Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 dimer state

Summary for 8VH5

• Entry DOI: 10.2210/pdb8vh5/pdb
• EMDB information: 43235
• Descriptor: Leucine-rich repeat serine/threonine-protein kinase 2, Ras-related protein Rab-12, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: cryo-em, parkinson's disease, kinase, lrrk2, rab gtpases, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 616261.84

Authors

Zhu, H.,Sun, J. (deposition date: 2023-12-30, release date: 2024-10-09)

• Primary citation: Li, X.,Zhu, H.,Huang, B.T.,Li, X.,Kim, H.,Tan, H.,Zhang, Y.,Choi, I.,Peng, J.,Xu, P.,Sun, J.,Yue, Z.; RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.; Nat Commun, 15:8434-8434, 2024; PubMed: 39343966; DOI: 10.1038/s41467-024-52723-6

Experimental method

ELECTRON MICROSCOPY (4 Å)