8VH5
Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 dimer state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 2527 | 286427.7 | 2 | UniProt (Q5S007) Pfam (PF13855) Pfam (PF08477) Pfam (PF16095) Pfam (PF00069) | Homo sapiens (human) | Dardarin |
| 2 | B, D (B, D) | Ras-related protein Rab-12 | polymer | 176 | 20207.4 | 2 | UniProt (Q6IQ22) Pfam (PF00071) | Homo sapiens (human) | |
| 3 | E, I (A, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 4 | F, J (A, C) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 5 | G, K (B, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | H, L (B, D) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 2 | Chemie (GNP) |
Sequence modifications
A, C: 1 - 2527 (UniProt: Q5S007)
B, D: 36 - 211 (UniProt: Q6IQ22)
| PDB | External Database | Details |
|---|---|---|
| His 50 | Arg 50 | conflict |
| Thr 1647 | Ser 1647 | conflict |
| Thr 2397 | Met 2397 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 101 | Gln 101 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 613270.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2991.8 | |
| All* | Total formula weight | 616261.8 |
