5F2B

Expanding Nature's Catalytic Repertoire -Directed Evolution of an Artificial Metalloenzyme for In Vivo Metathesis

Summary for 5F2B

Entry DOI	10.2210/pdb5f2b/pdb
Descriptor	Streptavidin, [1-[4-[[5-[(3~{a}~{S},4~{S},6~{a}~{R})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]methyl]-2,6-dimethyl-phenyl]-3-(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-1-ium-2-yl]-bis(chloranyl)ruthenium, SULFATE ION, ... (4 entities in total)
Functional Keywords	biotin-binding protein, beta barrel, metathesis, organometallic complex
Biological source	Streptomyces avidinii
Cellular location	Secreted: P22629
Total number of polymer chains	1
Total formula weight	17413.85
Authors	Heinisch, T.,Jeschek, M.,Reuter, R.,Trindler, C.,Panke, S.,Ward, T.R. (deposition date: 2015-12-01, release date: 2016-08-31, Last modification date: 2024-01-10)
Primary citation	Jeschek, M.,Reuter, R.,Heinisch, T.,Trindler, C.,Klehr, J.,Panke, S.,Ward, T.R. Directed evolution of artificial metalloenzymes for in vivo metathesis. Nature, 537:661-665, 2016 Cited by PubMed: 27571282 DOI: 10.1038/nature19114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation