7SYN
| Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 8(delta dII) | Descriptor: | 18S rRNA, 40S ribosomal protein S2, HCV IRES, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA To Be Published
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7SYJ
| Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 4(delta dII) | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYL
| Structure of the HCV IRES bound to the 40S ribosomal subunit, closed conformation. Structure 6(delta dII) | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYX
| Structure of the delta dII IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(delta dII) | Descriptor: | 18S rRNA, 40S ribosomal protein S24, 40S ribosomal protein S25, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SRR
| 5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM) | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2B, G protein subunit q (Gi2-mini-Gq chimera), ... | Authors: | Barros-Alvarez, X, Kim, K, Panova, O, Cao, C, Roth, B.L, Skiniotis, G. | Deposit date: | 2021-11-08 | Release date: | 2022-09-21 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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7V35
| Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GCGR-Gs complex | Descriptor: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, F.h, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | Deposit date: | 2021-08-10 | Release date: | 2022-03-02 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022
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7TZF
| Human Amylin3 Receptor in complex with Gs and rat amylin peptide | Descriptor: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | Deposit date: | 2022-02-15 | Release date: | 2022-03-23 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | A structural basis for amylin receptor phenotype. Science, 375, 2022
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7TYL
| Calcitonin Receptor in complex with Gs and rat amylin peptide, bypass motif | Descriptor: | Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | Deposit date: | 2022-02-13 | Release date: | 2022-03-23 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A structural basis for amylin receptor phenotype. Science, 375, 2022
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7TYH
| Human Amylin2 Receptor in complex with Gs and human calcitonin peptide | Descriptor: | Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | Deposit date: | 2022-02-13 | Release date: | 2022-03-23 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A structural basis for amylin receptor phenotype. Science, 375, 2022
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7TYO
| Calcitonin receptor in complex with Gs and human calcitonin peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin, ... | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | Deposit date: | 2022-02-14 | Release date: | 2022-03-23 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | A structural basis for amylin receptor phenotype. Science, 375, 2022
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7TYY
| Human Amylin2 Receptor in complex with Gs and salmon calcitonin peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ... | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | Deposit date: | 2022-02-14 | Release date: | 2022-03-23 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | A structural basis for amylin receptor phenotype. Science, 375, 2022
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7TYN
| Calcitonin Receptor in complex with Gs and salmon calcitonin peptide | Descriptor: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | Deposit date: | 2022-02-13 | Release date: | 2022-03-30 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | A structural basis for amylin receptor phenotype. Science, 375, 2022
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7TYF
| Human Amylin1 Receptor in complex with Gs and rat amylin peptide | Descriptor: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | Deposit date: | 2022-02-13 | Release date: | 2022-03-23 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | A structural basis for amylin receptor phenotype. Science, 375, 2022
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7TYW
| Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ... | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | Deposit date: | 2022-02-14 | Release date: | 2022-03-23 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | A structural basis for amylin receptor phenotype. Science, 375, 2022
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7TYX
| Human Amylin2 Receptor in complex with Gs and rat amylin peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ... | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | Deposit date: | 2022-02-14 | Release date: | 2022-03-30 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | A structural basis for amylin receptor phenotype. Science, 375, 2022
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7UCJ
| Mammalian 80S translation initiation complex with mRNA and Harringtonine | Descriptor: | 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... | Authors: | Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. | Deposit date: | 2022-03-16 | Release date: | 2022-06-01 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Mol.Cell, 82, 2022
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7UCK
| 80S translation initiation complex with ac4c(-1) mRNA and Harringtonine | Descriptor: | 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... | Authors: | Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. | Deposit date: | 2022-03-16 | Release date: | 2022-06-01 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Mol.Cell, 82, 2022
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7UNG
| 48-nm repeat of the human respiratory doublet microtubule | Descriptor: | Cilia- and flagella-associated protein 161, Cilia- and flagella-associated protein 20, Cilia- and flagella-associated protein 45, ... | Authors: | Gui, M, Croft, J.T, Zabeo, D, Acharya, V, Kollman, J.M, Burgoyne, T, Hoog, J.L, Brown, A. | Deposit date: | 2022-04-11 | Release date: | 2022-10-05 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules. Proc.Natl.Acad.Sci.USA, 119, 2022
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7UD5
| Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome | Descriptor: | 601 DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Niklas, H.A, Rahman, S, Worden, E.J, Wolberger, C. | Deposit date: | 2022-03-18 | Release date: | 2022-09-21 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (4.25 Å) | Cite: | Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome. Proc.Natl.Acad.Sci.USA, 119, 2022
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7UM7
| CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine | Descriptor: | (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, S, Fay, J.F, Roth, B.L. | Deposit date: | 2022-04-06 | Release date: | 2022-07-20 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7UM5
| CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT | Descriptor: | 3-(2-azanylethyl)-1H-indole-5-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, S, Fay, J.F, Roth, B.L. | Deposit date: | 2022-04-06 | Release date: | 2022-07-20 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7UND
| Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | Authors: | Filipovski, M, Vos, S.M, Farnung, L. | Deposit date: | 2022-04-10 | Release date: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of nucleosome retention during transcription elongation. Science, 376, 2022
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7UNC
| Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | Authors: | Filipovski, M, Vos, S.M, Farnung, L. | Deposit date: | 2022-04-10 | Release date: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of nucleosome retention during transcription elongation. Science, 376, 2022
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7UM6
| CryoEM structure of Go-coupled 5-HT5AR in complex with Lisuride | Descriptor: | 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, S, Fay, J.F, Roth, B.L. | Deposit date: | 2022-04-06 | Release date: | 2022-07-20 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7V2Y
| cryo-EM structure of yeast THO complex with Sub2 | Descriptor: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2, ... | Authors: | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | Deposit date: | 2021-08-10 | Release date: | 2022-07-27 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing), 66, 2021
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