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1PGZ	Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI) Descriptor: 5'-D(*T*TP*AP*GP*GP*GP*TP*TP*AP*GP*(6MI)P*G)-3', Heterogeneous nuclear ribonucleoprotein A1 Authors: Myers, J.C, Moore, S.A, Shamoo, Y. Deposit date: 2003-05-28 Release date: 2003-11-11 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure-based incorporation of 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine into the human telomeric repeat DNA as a probe for UP1 binding and destabilization of G-tetrad structures J.Biol.Chem., 278, 2003
8BPA	Cryo-EM structure of the human SIN3B histone deacetylase complex at 3.7 Angstrom Descriptor: CALCIUM ION, Histone deacetylase 2, Isoform 2 of Paired amphipathic helix protein Sin3b, ... Authors: Wan, M.S.M, Muhammad, R, Koliopolous, M.G, Alfieri, C. Deposit date: 2022-11-16 Release date: 2023-05-10 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. Nat Commun, 14, 2023
8BPB	Cryo-EM structure of the human SIN3B histone deacetylase core complex at 2.8 Angstrom Descriptor: ACETATE ION, CALCIUM ION, Histone deacetylase 2, ... Authors: Wan, M.S.M, Muhammad, R, Koliopolous, M.G, Alfieri, C. Deposit date: 2022-11-16 Release date: 2023-05-10 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. Nat Commun, 14, 2023
8BPC	Cryo-EM structure of the human SIN3B histone deacetylase core complex with SAHA at 2.8 Angstrom Descriptor: CALCIUM ION, Histone deacetylase 2, Isoform 2 of Paired amphipathic helix protein Sin3b, ... Authors: Wan, M.S.M, Muhammad, R, Koliopolous, M.G, Alfieri, C. Deposit date: 2022-11-16 Release date: 2023-05-10 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. Nat Commun, 14, 2023
8QO9	Cryo-EM structure of a human spliceosomal B complex protomer Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. Deposit date: 2023-09-28 Release date: 2024-01-24 Last modified: 2024-08-07 Method: ELECTRON MICROSCOPY (5.29 Å) Cite: Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. Embo J., 43, 2024
8Q7N	cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. Deposit date: 2023-08-16 Release date: 2024-01-24 Last modified: 2024-08-07 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. Embo J., 43, 2024
8CH6	Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex). Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... Authors: Cretu, C, Schmitzova, J, Pena, V. Deposit date: 2023-02-07 Release date: 2023-05-10 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (5.9 Å) Cite: Structural basis of catalytic activation in human splicing. Nature, 617, 2023
8CLJ	TFIIIC TauB-DNA dimer Descriptor: General transcription factor 3C polypeptide 1, General transcription factor 3C polypeptide 2, General transcription factor 3C polypeptide 4, ... Authors: Seifert-Davila, W, Girbig, M, Hauptmann, L, Hoffmann, T, Eustermann, S, Mueller, C.W. Deposit date: 2023-02-16 Release date: 2023-06-21 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural insights into human TFIIIC promoter recognition. Sci Adv, 9, 2023
8CLL	Structural insights into human TFIIIC promoter recognition Descriptor: General transcription factor 3C polypeptide 1, General transcription factor 3C polypeptide 2, General transcription factor 3C polypeptide 4, ... Authors: Seifert-Davila, W, Girbig, M, Hauptmann, L, Hoffmann, T, Eustermann, S, Mueller, C.W. Deposit date: 2023-02-16 Release date: 2023-06-21 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural insights into human TFIIIC promoter recognition. Sci Adv, 9, 2023
8CLI	TFIIIC TauB-DNA monomer Descriptor: DNA (35-MER), General transcription factor 3C polypeptide 1, General transcription factor 3C polypeptide 2, ... Authors: Seifert-Davila, W, Girbig, M, Hauptmann, L, Hoffmann, T, Eustermann, S, Mueller, C.W. Deposit date: 2023-02-16 Release date: 2023-06-21 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural insights into human TFIIIC promoter recognition. Sci Adv, 9, 2023
7SYN	Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 8(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S2, HCV IRES, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Method: ELECTRON MICROSCOPY (4 Å) Cite: Molecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA To Be Published
6H3A	Crystal structure of the KAP1 RBCC domain in complex with the SMARCAD1 CUE1 domain. Descriptor: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1, Transcription intermediary factor 1-beta, ZINC ION Authors: Newman, J.A, Aitkenhead, H, Lim, M, Williams, H.L, Svejstrup, J.Q, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2018-07-17 Release date: 2019-06-26 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (5.505 Å) Cite: A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin. Structure, 27, 2019
7SYG	Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 1(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S24, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Molecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA To Be Published
7SYM	Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 7(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S21, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Comprehensive structural overview of the HCV IRES-mediated translation initiation pathway To Be Published
7SYU	Structure of the delta dII IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2023-02-01 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYT	Structure of the wt IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(wt) Descriptor: 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2023-02-01 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYH	Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 2(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Molecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA To Be Published
6FF4	human Bact spliceosome core structure Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... Authors: Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H. Deposit date: 2018-01-03 Release date: 2018-08-29 Last modified: 2020-10-07 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure and Conformational Dynamics of the Human Spliceosomal BactComplex. Cell, 172, 2018
7SYP	Structure of the wt IRES and 40S ribosome binary complex, open conformation. Structure 10(wt) Descriptor: 18S rRNA, HCV IRES, HCV IRES partially loaded mRNA portion, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-27 Last modified: 2022-08-24 Method: ELECTRON MICROSCOPY (4 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7TM3	Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. Deposit date: 2022-01-19 Release date: 2022-10-19 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
1A3S	HUMAN UBC9 Descriptor: UBC9 Authors: Naismith, J.H, Giraud, M. Deposit date: 1998-01-23 Release date: 1998-05-27 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of ubiquitin-conjugating enzyme 9 displays significant differences with other ubiquitin-conjugating enzymes which may reflect its specificity for sumo rather than ubiquitin. Acta Crystallogr.,Sect.D, 54, 1998
5B7A	SOLUTION STRUCTURE OF LYS37 ACETYLATED HUMAN SUMO1 Descriptor: Small ubiquitin-related modifier 1 Authors: Naik, M.T, Naik, N, Shih, H, Huang, T. Deposit date: 2016-06-05 Release date: 2017-06-07 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Structures Of Human Sumo To Be Published
5WWF	Crystal structure of hnRNPA2B1 in complex with RNA Descriptor: Heterogeneous nuclear ribonucleoproteins A2/B1, RNA Authors: Wu, B.X, Su, S.C, Ma, J.B. Deposit date: 2017-01-01 Release date: 2018-01-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1. Nat Commun, 9, 2018
8Y0W	dormant ribosome with eIF5A, eEF2 and SERBP1 Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... Authors: Du, M, Zeng, F. Deposit date: 2024-01-23 Release date: 2024-02-07 Last modified: 2024-08-21 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes. Front Mol Biosci, 11, 2024
4FO9	Crystal structure of the E3 SUMO Ligase PIAS2 Descriptor: E3 SUMO-protein ligase PIAS2, UNKNOWN ATOM OR ION, ZINC ION Authors: Dong, A, Hu, J, Dobrovetsky, E, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) Deposit date: 2012-06-20 Release date: 2012-07-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Crystal structure of the E3 SUMO Ligase PIAS2 to be published

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