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2K40	NMR structure of HESX-1 homeodomain double mutant R31L/E42L Descriptor: Homeobox expressed in ES cells 1 Authors: Asensio, J, Torrado, M, Gonzalez, C, Bastida, A. Deposit date: 2008-05-26 Release date: 2009-05-05 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: The role of conserved salt-bridges on homeodomain stability To be Published
4F8C	Structure of the Cif:Nedd8 complex - Yersinia pseudotuberculosis Cycle Inhibiting Factor in complex with human Nedd8 Descriptor: 1,2-ETHANEDIOL, Cycle Inhibiting Factor, NEDD8 Authors: Crow, A, Banfield, M. Deposit date: 2012-05-17 Release date: 2012-06-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.95 Å) Cite: The molecular basis of Nedd8 deamidation by the bacterial effector protein Cif Proc.Natl.Acad.Sci.USA, 2012
2KG4	Three-dimensional structure of human Gadd45alpha in solution by NMR Descriptor: Growth arrest and DNA-damage-inducible protein GADD45 alpha Authors: Sanchez, R, Pantoja-Uceda, D, Prieto, J, Diercks, T, Campos-Olivas, R, Blanco, F.J. Deposit date: 2009-03-04 Release date: 2009-03-31 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase J.Biol.Chem., 285, 2010
5VQF	Crystal Structure of pro-TGF-beta 1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A. Deposit date: 2017-05-08 Release date: 2017-11-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Prodomain-growth factor swapping in the structure of pro-TGF-beta 1. J. Biol. Chem., 293, 2018
5W3G	Solution Structure of ETS Transcription Factor PU.1 Descriptor: Transcription factor PU.1 Authors: Lau, D.K.W, Okon, M, McIntosh, L.P. Deposit date: 2017-06-07 Release date: 2018-06-13 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Conserved protein dynamics within the ETS transcription factor family To be published
1EKU	CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA Descriptor: Interferon gamma, SULFATE ION Authors: Landar, A, Curry, B, Parker, M.H, DiGiacomo, R, Indelicato, S.R, Walter, M.R. Deposit date: 2000-03-09 Release date: 2000-09-01 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma. J.Mol.Biol., 299, 2000
1HIG	THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA. Descriptor: INTERFERON-GAMMA Authors: Ealick, S.E, Cook, W.J, Vijay-Kumar, S, Carson, M, Nagabhushan, T.L, Trotta, P.P, Bugg, C.E. Deposit date: 1991-10-03 Release date: 1992-04-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Three-dimensional structure of recombinant human interferon-gamma. Science, 252, 1991
2R3J	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-bromo-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3H	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-methyl-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3L	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-bromo-6-phenyl-N-(pyrimidin-5-ylmethyl)imidazo[1,2-a]pyridin-8-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3O	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: (5-phenyl-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methanol, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3I	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3M	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: Cell division protein kinase 2, N-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amine Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3Q	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor Descriptor: 3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide, Cell division protein kinase 2 Authors: Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. Deposit date: 2007-08-29 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
8WDK	The complex structure of Cul2-VCB-Protac-Wee1 Descriptor: (2S,4R)-1-[(2S)-3,3-dimethyl-2-[3-[4-[4-[4-[[3-oxidanylidene-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]-2-prop-2-enyl-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]piperazin-1-yl]butoxy]propanoylamino]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... Authors: Wang, P, Zhang, T.T. Deposit date: 2023-09-15 Release date: 2024-09-18 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: Structure of Cul2-VCB-Protac-Wee1 complex at 3.6 Angstrom resolution. To Be Published
3RJR	Crystal Structure of pro-TGF beta 1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1 Authors: Zhu, J.H, Shi, M.L, Springer, T.A. Deposit date: 2011-04-15 Release date: 2011-06-15 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Latent TGF-Beta structure and activation Nature, 474, 2011
3RKQ	NKX2.5 Homeodomain dimer bound to ANF-242 DNA Descriptor: ANF-242 DNA, Homeobox protein Nkx-2.5, MAGNESIUM ION Authors: Genis, C, Scone, P, Kasahara, H, Nam, H.-J. Deposit date: 2011-04-18 Release date: 2012-05-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry, 51, 2012
5XYL	Solution Structure of Skp1 from Homo sapiens Descriptor: S-phase kinase-associated protein 1 Authors: Shukla, V.K, Kachariya, N.N, Bhattacharya, A, Dantu, S.C, Kumar, A. Deposit date: 2017-07-09 Release date: 2018-07-11 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Structural and dynamics insight of the recognition of Fbox protein by Skp1 To Be Published
6WNX	FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide Descriptor: Catenin beta-1, F-box/WD repeat-containing protein 11, GLYCEROL, ... Authors: Ivanochko, D, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Boettcher, J, Structural Genomics Consortium (SGC) Deposit date: 2020-04-23 Release date: 2020-05-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide To Be Published
7T1Y	Structure of the Fbw7-Skp1-MycCdegron complex Descriptor: F-box/WD repeat-containing protein 7, Myc proto-oncogene protein C terminal degron, S-phase kinase-associated protein 1, ... Authors: Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N. Deposit date: 2021-12-02 Release date: 2022-02-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor. Sci Adv, 8, 2022
2L7F	Solution Structure of the Pitx2 Homeodomain Descriptor: Pituitary homeobox 2 Authors: Doerdelmann, T, Rance, M, Baird-Titus, J.M, Kojetin, D.J. Deposit date: 2010-12-08 Release date: 2011-12-14 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution Structure of the Pitx2 Homeodomain To be Published
6FE8	Cryo-EM structure of the core Centromere Binding Factor 3 complex Descriptor: Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, Suppressor of kinetochore protein 1 Authors: Zhang, W.J, Lukoynova, N, Miah, S, Vaughan, C.K. Deposit date: 2017-12-30 Release date: 2018-08-01 Last modified: 2019-12-11 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Insights into Centromere DNA Bending Revealed by the Cryo-EM Structure of the Core Centromere Binding Factor 3 with Ndc10. Cell Rep, 24, 2018
6HG9	Crystal Structure of the human IL-17RC ECD in complex with human IL-17F, Crystal form II Descriptor: Interleukin-17 receptor C, Interleukin-17F Authors: Rondeau, J.M, Goepfert, A. Deposit date: 2018-08-23 Release date: 2020-03-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.62 Å) Cite: Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. Immunity, 52, 2020
6HG4	Crystal Structure of the human IL-17RC ECD in complex with human IL-17F Descriptor: Interleukin-17 receptor C, Interleukin-17F Authors: Rondeau, J.M, Goepfert, A. Deposit date: 2018-08-22 Release date: 2020-03-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.32 Å) Cite: Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. Immunity, 52, 2020
8SV1	Caspase-1 complex with interleukin-18 Descriptor: Caspase-1, Interleukin-18 Authors: Dong, Y, Pascal, D, Jon, K, Wu, H. Deposit date: 2023-05-15 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Caspase-1 complex with interleukin-18 To Be Published

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