2V1T
| CRYSTAL STRUCTURE OF RAT TOM20-ALDH PRESEQUENCE COMPLEX | Descriptor: | ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 HOMOLOG | Authors: | Obita, T, Igura, M, Ose, T, Endo, T, Maenaka, K, Kohda, D. | Deposit date: | 2007-05-29 | Release date: | 2007-06-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Tom20 Recognizes Mitochondrial Presequences Through Dynamic Equilibrium Among Multiple Bound States. Embo J., 26, 2007
|
|
5N3E
| cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule 6-dimethylaminopyridine-3-carboxylic acid | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 6-(dimethylamino)pyridine-3-carboxylic acid, DIMETHYL SULFOXIDE, ... | Authors: | Siefker, C, Heine, A, Klebe, G. | Deposit date: | 2017-02-08 | Release date: | 2018-03-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.529 Å) | Cite: | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 2020
|
|
2UUU
| alkyldihydroxyacetonephosphate synthase in P212121 | Descriptor: | ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, FLAVIN-ADENINE DINUCLEOTIDE, HEXADECAN-1-OL | Authors: | Razeto, A, Mattiroli, F, Carpanelli, E, Aliverti, A, Pandini, V, Coda, A, Mattevi, A. | Deposit date: | 2007-03-07 | Release date: | 2007-06-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The Crucial Step in Ether Phospholipid Biosynthesis: Structural Basis of a Noncanonical Reaction Associated with a Peroxisomal Disorder. Structure, 15, 2007
|
|
7CFN
| Cryo-EM structure of the INT-777-bound GPBAR-Gs complex | Descriptor: | (2S,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-ethyl-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-pentanoic acid, CHOLESTEROL, G-protein coupled bile acid receptor 1, ... | Authors: | Yang, F, Mao, C, Guo, L, Lin, J, Ming, Q, Xiao, P, Wu, X, Shen, Q, Guo, S, Shen, D, Lu, R, Zhang, L, Huang, S, Ping, Y, Zhang, C, Ma, C, Zhang, K, Liang, X, Shen, Y, Nan, F, Yi, F, Luca, V, Zhou, J, Jiang, C, Sun, J, Xie, X, Yu, X, Zhang, Y. | Deposit date: | 2020-06-27 | Release date: | 2020-09-09 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of GPBAR activation and bile acid recognition. Nature, 587, 2020
|
|
2VLQ
| F86A mutant of E9 DNase domain in complex with Im9 | Descriptor: | COLICIN E9, COLICIN-E9 IMMUNITY PROTEIN, MALONIC ACID | Authors: | Keeble, A.H, Joachimiak, L.A, Mate, M.J, Meenan, N, Kirkpatrick, N, Baker, D, Kleanthous, C. | Deposit date: | 2008-01-15 | Release date: | 2008-05-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Experimental and Computational Analyses of the Energetic Basis for Dual Recognition of Immunity Proteins by Colicin Endonucleases. J.Mol.Biol., 379, 2008
|
|
6RWX
| |
7WOX
| PPARgamma antagonist (MMT-160)- PPARgamma LBD complex | Descriptor: | N-[[5-(3-phenylprop-2-ynoylamino)-2-propoxy-phenyl]methyl]-4-pyrimidin-2-yl-benzamide, Peroxisome proliferator-activated receptor gamma | Authors: | Yoshizawa, M, Aoyama, T, Itoh, T, Miyachi, H. | Deposit date: | 2022-01-22 | Release date: | 2022-04-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Arylalkynyl amide-type peroxisome proliferator-activated receptor gamma (PPAR gamma )-selective antagonists covalently bind to the PPAR gamma ligand binding domain with a unique binding mode. Bioorg.Med.Chem.Lett., 64, 2022
|
|
7W0D
| Dicer2-LoqsPD-dsRNA complex at mid-translocation state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dicer-2, isoform A, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
|
|
7W0B
| Dicer2-LoqsPD complex at apo status | Descriptor: | Dicer-2, isoform A, Loquacious, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
|
|
4WQS
| Thermus thermophilus RNA polymerase backtracked complex | Descriptor: | DNA (28-MER), DNA (5'-D(P*GP*TP*AP*GP*CP*TP*TP*GP*TP*GP*GP*TP*AP*GP*TP*GP*AP*CP*GP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Murayama, Y, Sekine, S, Yokoyama, S. | Deposit date: | 2014-10-22 | Release date: | 2015-02-18 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (4.306 Å) | Cite: | The Ratcheted and Ratchetable Structural States of RNA Polymerase Underlie Multiple Transcriptional Functions. Mol.Cell, 57, 2015
|
|
7W0E
| dmDicer2-LoqsPD-dsRNA Active-dicing status | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dicer-2, isoform A, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (4.03 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
|
|
7W0F
| dmDicer2-LoqsPD-dsRNA Post-dicing status | Descriptor: | Dicer-2, isoform A, Loquacious, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (4.55 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
|
|
3JRV
| |
7W0A
| dmDicer2-LoqsPD-dsRNA Dimer status | Descriptor: | Dicer-2, isoform A, Loquacious, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
|
|
7W0C
| Dicer2-Loqs-PD-dsRNA complex at early-translocation state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dicer-2, isoform A, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
|
|
5NQ5
| Mtb TMK crystal structure in complex with compound 1 | Descriptor: | 5-methyl-1-[(3~{S})-1-[(3-phenoxyphenyl)methyl]piperidin-3-yl]pyrimidine-2,4-dione, Thymidylate kinase | Authors: | Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S. | Deposit date: | 2017-04-19 | Release date: | 2018-03-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors. J. Med. Chem., 61, 2018
|
|
6U7E
| HCoV-229E RBD Class III in complex with human APN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | Authors: | Tomlinson, A.C.A, Li, Z, Rini, J.M. | Deposit date: | 2019-09-02 | Release date: | 2019-11-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The human coronavirus HCoV-229E S-protein structure and receptor binding. Elife, 8, 2019
|
|
7AZ9
| Perdeuterated E65Q-TIM complexed with PHOSPHOGLYCOLOHYDROXAMATE | Descriptor: | PHOSPHOGLYCOLOHYDROXAMIC ACID, Triosephosphate isomerase | Authors: | Kelpsas, V, Caldararu, O, von Wachenfeldt, C, Oksanen, E. | Deposit date: | 2020-11-16 | Release date: | 2021-07-28 | Last modified: | 2024-05-01 | Method: | NEUTRON DIFFRACTION (1.1 Å), X-RAY DIFFRACTION | Cite: | Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps. Iucrj, 8, 2021
|
|
7AZ3
| Perdeuterated E65Q-TIM complexed with 2-PHOSPHOGLYCOLIC ACID | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate isomerase | Authors: | Kelpsas, V, Caldararu, O, von Wachenfeldt, C, Oksanen, E. | Deposit date: | 2020-11-16 | Release date: | 2021-07-28 | Last modified: | 2024-05-01 | Method: | NEUTRON DIFFRACTION (1.15 Å), X-RAY DIFFRACTION | Cite: | Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps. Iucrj, 8, 2021
|
|
7AZA
| Perdeuterated E65Q-TIM complexed with PHOSPHOGLYCOLOHYDROXAMATE | Descriptor: | PHOSPHOGLYCOLOHYDROXAMIC ACID, Triosephosphate isomerase | Authors: | Kelpsas, V, Caldararu, O, von Wachenfeldt, C, Oksanen, E. | Deposit date: | 2020-11-16 | Release date: | 2021-07-28 | Last modified: | 2024-05-01 | Method: | NEUTRON DIFFRACTION (1.1 Å), X-RAY DIFFRACTION | Cite: | Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps. Iucrj, 8, 2021
|
|
7AZ4
| Perdeuterated E65Q-TIM complexed with 2-PHOSPHOGLYCOLIC ACID | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate isomerase | Authors: | Kelpsas, V, Caldararu, O, von Wachenfeldt, C, Oksanen, E. | Deposit date: | 2020-11-16 | Release date: | 2021-07-28 | Last modified: | 2024-05-01 | Method: | NEUTRON DIFFRACTION (1.15 Å), X-RAY DIFFRACTION | Cite: | Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps. Iucrj, 8, 2021
|
|
4WH5
| Crystal structure of lincosamide antibiotic adenylyltransferase LnuA, lincomycin-bound | Descriptor: | CHLORIDE ION, LINCOMYCIN, Lincosamide resistance protein, ... | Authors: | Stogios, P.J, Dong, A, Minasov, G, Evdokimova, E, Egorova, O, Kudritska, M, Yim, O, Courvalin, P, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2014-09-20 | Release date: | 2014-11-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | CRYSTAL STRUCTURE OF LINCOSAMIDE ANTIBIOTIC ADENYLYLTRANSFERASE LNUA, LINCOMYCIN BOUND To Be Published
|
|
4NWG
| Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | Authors: | Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battalie, K, Chirgadze, N.Y. | Deposit date: | 2013-12-06 | Release date: | 2014-12-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation To be Published
|
|
7JMS
| Structure of the Hazara virus OTU bound to ubiquitin | Descriptor: | CALCIUM ION, GLYCEROL, Polyubiquitin-B, ... | Authors: | Dzimianski, J.V, Pegan, S.D. | Deposit date: | 2020-08-02 | Release date: | 2020-10-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis. Acta Crystallogr D Struct Biol, 76, 2020
|
|
4WIA
| |