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5B42
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BU of 5b42 by Molmil
Crystal structure of the C-terminal endonuclease domain of Aquifex aeolicus MutL.
Descriptor: CADMIUM ION, DI(HYDROXYETHYL)ETHER, DNA mismatch repair protein MutL
Authors:Fukui, K, Baba, S, Kumasaka, T, Yano, T.
Deposit date:2016-03-30
Release date:2016-07-13
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural Features and Functional Dependency on beta-Clamp Define Distinct Subfamilies of Bacterial Mismatch Repair Endonuclease MutL
J.Biol.Chem., 291, 2016
8PEP
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BU of 8pep by Molmil
H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex - pose 2
Descriptor: Histone H2A, Histone H2B 1.1, Histone H3, ...
Authors:Koutna, E, Kouba, T, Veverka, V.
Deposit date:2023-06-14
Release date:2023-08-16
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
8PEO
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BU of 8peo by Molmil
H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex
Descriptor: (2R)-2-amino-3-(2-dimethylaminoethylsulfanyl)propanoic acid, Histone H2A, Histone H2B 1.1, ...
Authors:Koutna, E, Kouba, T, Veverka, V.
Deposit date:2023-06-14
Release date:2023-08-16
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
6HZ6
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BU of 6hz6 by Molmil
Structure of McrBC without DNA binding domains (Class 2)
Descriptor: 5-methylcytosine-specific restriction enzyme B, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Itoh, Y, Nirwan, N, Saikrishnan, K, Amunts, A.
Deposit date:2018-10-22
Release date:2019-07-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC.
Nat Commun, 10, 2019
8Q2N
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BU of 8q2n by Molmil
Cas1-Cas2 CRISPR integrase bound to prespacer and target DNA, Streptococcus thermophilus DGCC 7710 CRISPR3 system
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, Integration target, ...
Authors:Sasnauskas, G, Gaizauskaite, U, Tamulaitiene, G.
Deposit date:2023-08-02
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structural basis for spacer acquisition in a type II-A CRISPR-Cas system
To be published
3Q22
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BU of 3q22 by Molmil
X-ray crystal structure of the N4 mini-VRNAP and P2_7a promoter transcription initiation complex with GTP and Magnesium: substrate complex I
Descriptor: DIHYDROGENPHOSPHATE ION, DNA (5'-D(*TP*GP*CP*CP*TP*CP*CP*CP*AP*GP*GP*CP*AP*TP*CP*CP*AP*AP*AP*AP*GP*AP*AP*GP*CP*GP*GP*AP*GP*CP*TP*TP*CP*TP*TP*C)-3'), GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Gleghorn, M.L, Murakami, K.S.
Deposit date:2010-12-19
Release date:2011-02-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides.
Proc.Natl.Acad.Sci.USA, 108, 2011
1PWF
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BU of 1pwf by Molmil
One Sugar Pucker Fits All: Pairing Versatility Despite Conformational Uniformity in TNA
Descriptor: 5'-D(*GP*CP*GP*TP*AP*(2MU)P*(FA2)P*CP*GP*C)-3', SPERMINE
Authors:Pallan, P.S, Wilds, C.J, Wawrzak, Z, Krishnamurthy, R, Eschenmoser, A, Egli, M.
Deposit date:2003-07-01
Release date:2004-07-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Why does TNA cross-pair more strongly with RNA than with DNA? an answer from X-ray analysis.
ANGEW.CHEM.INT.ED.ENGL., 42, 2003
6VWB
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BU of 6vwb by Molmil
Solution structure of the N-terminal helix-hairpin-helix domain of human MUS81
Descriptor: Crossover junction endonuclease MUS81
Authors:Payliss, B, Houliston, S, Lemak, A, Arrowsmith, C.H, Wyatt, H.D.M.
Deposit date:2020-02-19
Release date:2021-02-24
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease
Cell Rep, 41, 2022
5AY8
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BU of 5ay8 by Molmil
Crystal structure of human nucleosome containing H3.Y
Descriptor: CHLORIDE ION, DNA (146-MER), H3.Y, ...
Authors:Kujirai, T, Horikoshi, N, Sato, K, Maehara, K, Machida, S, Osakabe, A, Kimura, H, Ohkawa, Y, Kurumizaka, H.
Deposit date:2015-08-10
Release date:2016-04-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and function of human histone H3.Y nucleosome
Nucleic Acids Res., 44, 2016
4B2H
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BU of 4b2h by Molmil
COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS
Descriptor: 3-[7,8-dimethyl-2,4-bis(oxidanylidene)benzo[g]pteridin-10-yl]propylcarbamic acid, CHLORIDE ION, DODECIN, ...
Authors:Yu, Y, Heidel, B, Parapugna, T.L, Wenderhold-Reeb, S, Song, B, Schoenherr, H, Grininger, M, Noell, G.
Deposit date:2012-07-16
Release date:2013-05-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Flavoprotein Dodecin as a Redox Probe for Electron Transfer Through DNA.
Angew.Chem.Int.Ed.Engl., 52, 2013
8D2N
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BU of 8d2n by Molmil
Structure of Acidothermus cellulolyticus Cas9 ternary complex (Pre-cleavage)
Descriptor: CRISPR-associated endonuclease, Csn1 family, DNA non-target strand (5'-D(P*TP*AP*CP*AP*CP*CP*AP*AP*GP*CP*T)-3'), ...
Authors:Rai, J, Das, A, Li, H.
Deposit date:2022-05-30
Release date:2023-12-20
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Coupled catalytic states and the role of metal coordination in Cas9.
Nat Catal, 6, 2023
6HZ4
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BU of 6hz4 by Molmil
Structure of McrBC without DNA binding domains (one half of the full complex)
Descriptor: 5-methylcytosine-specific restriction enzyme B, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Itoh, Y, Nirwan, N, Saikrishnan, K, Amunts, A.
Deposit date:2018-10-22
Release date:2019-07-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC.
Nat Commun, 10, 2019
6HZ9
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BU of 6hz9 by Molmil
Structure of McrBC without DNA binding domains (Class 5)
Descriptor: 5-methylcytosine-specific restriction enzyme B, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Itoh, Y, Nirwan, N, Saikrishnan, K, Amunts, A.
Deposit date:2018-10-22
Release date:2019-07-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC.
Nat Commun, 10, 2019
8GM6
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BU of 8gm6 by Molmil
Structure of apurinic/apyrimidinic DNA lyase TK0353 from Thermococcus kodakarensis (Selenomethionine)
Descriptor: GLYCEROL, SULFATE ION, TK0353
Authors:Eckenroth, B.E, Gardner, A.F, Doublie, S.
Deposit date:2023-03-24
Release date:2023-12-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold.
J.Biol.Chem., 300, 2023
8GM7
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BU of 8gm7 by Molmil
Structure of apurinic/apyrimidinic DNA Lyase TK0353 from Thermococcus kodakarensis (Native Crystal Form)
Descriptor: GLYCEROL, SULFATE ION, TK0353
Authors:Eckenroth, B.E, Gardner, A.F, Doublie, S.
Deposit date:2023-03-24
Release date:2023-12-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold.
J.Biol.Chem., 300, 2023
6HZ7
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BU of 6hz7 by Molmil
Structure of McrBC without DNA binding domains (Class 3)
Descriptor: 5-methylcytosine-specific restriction enzyme B, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Itoh, Y, Nirwan, N, Saikrishnan, K, Amunts, A.
Deposit date:2018-10-22
Release date:2019-07-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC.
Nat Commun, 10, 2019
1N0K
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BU of 1n0k by Molmil
NMR Structure of duplex DNA d(CCAAGGXCTTGGG), X is a 3' phosphoglycolate, 5'phosphate gapped lesion
Descriptor: 2-PHOSPHOGLYCOLIC ACID, 5'-D(*CP*CP*AP*AP*GP*G)-3', 5'-D(*CP*CP*CP*AP*AP*GP*GP*CP*CP*TP*TP*GP*G)-3', ...
Authors:Junker, H.-D, Hoehn, S.T, Bunt, R.C, Marathius, V, Chen, J, Turner, C.J, Stubbe, J.
Deposit date:2002-10-14
Release date:2003-01-07
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Synthesis, Characterization and Solution Structure of Tethered Oligonucleotides Containing an Internal 3'-Phosphoglycolate, 5'-Phosphate Gapped Lesion
Nucleic Acids Res., 30, 2002
1QEY
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BU of 1qey by Molmil
NMR Structure Determination of the Tetramerization Domain of the MNT Repressor: An Asymmetric A-Helical Assembly in Slow Exchange
Descriptor: PROTEIN (REGULATORY PROTEIN MNT)
Authors:Nooren, I.M.A, George, A.V.E, Kaptein, R, Sauer, R.T, Boelens, R.
Deposit date:1999-04-03
Release date:1999-08-18
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:The tetramerization domain of the Mnt repressor consists of two right-handed coiled coils.
Nat.Struct.Biol., 6, 1999
6HZ5
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BU of 6hz5 by Molmil
Structure of McrBC without DNA binding domains (Class 1)
Descriptor: 5-methylcytosine-specific restriction enzyme B, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Itoh, Y, Nirwan, N, Saikrishnan, K, Amunts, A.
Deposit date:2018-10-22
Release date:2019-07-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC.
Nat Commun, 10, 2019
3UNN
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BU of 3unn by Molmil
Monomeric structure of the human MDC1 FHA domain in complex with an MDC1 phospho-T4 peptide
Descriptor: Mediator of DNA damage checkpoint protein 1, phospho-T4 peptide from Mediator of DNA damage checkpoint protein 1
Authors:Luo, S, Ye, K.
Deposit date:2011-11-16
Release date:2012-01-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain
Nucleic Acids Res., 40, 2012
6HZ8
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BU of 6hz8 by Molmil
Structure of McrBC without DNA binding domains (Class 4)
Descriptor: 5-methylcytosine-specific restriction enzyme B, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Itoh, Y, Nirwan, N, Saikrishnan, K, Amunts, A.
Deposit date:2018-10-22
Release date:2019-07-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC.
Nat Commun, 10, 2019
5DCF
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BU of 5dcf by Molmil
C-terminal domain of XerD recombinase in complex with gamma domain of FtsK
Descriptor: Tyrosine recombinase XerD,DNA translocase FtsK
Authors:Keller, A.N, Xin, Y, Lowe, J, Grainge, I.
Deposit date:2015-08-24
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Activation of Xer-recombination at dif: structural basis of the FtsK gamma-XerD interaction.
Sci Rep, 6, 2016
2KQ5
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BU of 2kq5 by Molmil
Solution NMR structure of a section of the repeat domain of the type III effector protein PthA
Descriptor: Avirulence protein
Authors:Neves, J.L, Sforca, M.L, Murakami, M.T, Benedetti, C.E, Zeri, A.C.
Deposit date:2009-10-28
Release date:2010-09-01
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:An NMR-based structural model of the PthA repeat region reveals a TPR fold that would account for protein-protein and protein-DNA interactions
To be Published
1IN6
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BU of 1in6 by Molmil
THERMOTOGA MARITIMA RUVB K64R MUTANT
Descriptor: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, COBALT (II) ION, ...
Authors:Putnam, C.D, Clancy, S.B, Tsuruta, H, Wetmur, J.G, Tainer, J.A.
Deposit date:2001-05-12
Release date:2001-08-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and mechanism of the RuvB Holliday junction branch migration motor.
J.Mol.Biol., 311, 2001
3Q23
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BU of 3q23 by Molmil
X-ray crystal structure of the N4 mini-VRNAP and P2_7a promoter transcription initiation complex with GMPCPP and Manganese: sustrate complex II
Descriptor: DIHYDROGENPHOSPHATE ION, DNA (5'-D(*TP*GP*CP*CP*TP*CP*CP*CP*AP*GP*GP*CP*AP*TP*CP*CP*AP*AP*AP*AP*GP*AP*AP*GP*CP*GP*GP*AP*GP*CP*TP*TP*CP*TP*TP*C)-3'), MANGANESE (II) ION, ...
Authors:Gleghorn, M.L, Murakami, K.S.
Deposit date:2010-12-19
Release date:2011-02-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides.
Proc.Natl.Acad.Sci.USA, 108, 2011

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