PDB: 712 resultsInfo pagesStatus searchChemie searchBIRD

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7S4F	Protein Tyrosine Phosphatase 1B - F182Q mutant bound with Hepes Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, MAGNESIUM ION, ... Authors: Brandao, T.A.S, Hengge, A.C, Johnson, S.J. Deposit date: 2021-09-08 Release date: 2022-09-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
8XQD	The Crystal Structure of PTPRG from Biortus. Descriptor: Receptor-type tyrosine-protein phosphatase gamma Authors: Wang, F, Cheng, W, Lv, Z, Ju, C, Ni, C. Deposit date: 2024-01-05 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (2.55 Å) Cite: The Crystal Structure of PTPRG from Biortus. To Be Published
3ZV2	Human protein-tyrosine phosphatase 1b C215A, S216A mutant Descriptor: Tyrosine-protein phosphatase non-receptor type 1 Authors: Barford, D, Salmeen, A, Tonks, N.K. Deposit date: 2011-07-22 Release date: 2011-08-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell, 147, 2011
3ZMP	Src-derived peptide inhibitor complex of PTP1B Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 Authors: Temmerman, K, Pogenberg, V, Meyer, C, Koehn, M, Wilmanns, M. Deposit date: 2013-02-12 Release date: 2014-01-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.619 Å) Cite: Development of Accessible Peptidic Tool Compounds to Study the Phosphatase Ptp1B in Intact Cells. Acs Chem.Biol., 9, 2014
4BPC	Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form Descriptor: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S Authors: Jeon, T.J, Chien, P.N, Chun, H.J, Ryu, S.E. Deposit date: 2013-05-24 Release date: 2013-07-17 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form Mol.Cells, 36, 2013
3ZM3	Catalytic domain of human SHP2 Descriptor: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 Authors: Bohm, K, Schuetz, A, Roske, Y, Heinemann, U. Deposit date: 2013-02-04 Release date: 2014-04-23 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo. Chemmedchem, 10, 2015
3ZMQ	Src-derived mutant peptide inhibitor complex of PTP1B Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 Authors: Temmerman, K, Pogenberg, V, Meyer, C, Koehn, M, Wilmanns, M. Deposit date: 2013-02-12 Release date: 2014-01-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Development of Accessible Peptidic Tool Compounds to Study the Phosphatase Ptp1B in Intact Cells. Acs Chem.Biol., 9, 2014
3ZM1	Catalytic domain of human SHP2 Descriptor: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 Authors: Bohm, K, Schuetz, A, Roske, Y, Heinemann, U. Deposit date: 2013-02-04 Release date: 2014-04-23 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Selective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo. Chemmedchem, 10, 2015
4QBW	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. Deposit date: 2014-05-08 Release date: 2015-02-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.912 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
4QBE	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X. Deposit date: 2014-05-08 Release date: 2014-12-24 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.292 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
3BLT	Crystal structures of YopH complexed with PVSN and PVS, inhibitors of YopH which co-valent bind to Cys of active site Descriptor: Tyrosine-protein phosphatase yopH, phenyl ethenesulfonate Authors: Liu, S, Zhang, Z.-Y. Deposit date: 2007-12-11 Release date: 2009-02-10 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases. J.Am.Chem.Soc., 130, 2008
3BRH	Protein Tyrosine Phosphatase PTPN-22 (Lyp) bound to the mono-Phosphorylated Lck active site peptide Descriptor: Lck Active Site Peptide, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 22 Authors: Seidel, R.D, Love, J, Piserchio, A, Cowburn, D. Deposit date: 2007-12-21 Release date: 2009-02-17 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Lyp/PTPN22 Phosphatase Domain: Substrate Recognition and Specificity for Src family kinases To be Published
3CWE	PTP1B in complex with a phosphonic acid inhibitor Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1, [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid Authors: Scapin, G, Han, Y, Kennedy, B.P. Deposit date: 2008-04-21 Release date: 2008-06-10 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor Bioorg.Med.Chem.Lett., 18, 2008
3D9C	Crystal Structure PTP1B complex with aryl Seleninic acid Descriptor: (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid, Tyrosine-protein phosphatase non-receptor type 1 Authors: Abdo, M, Liu, S, Zhou, B, Walls, C.D, Knapp, S, Zhang, Z.-Y. Deposit date: 2008-05-27 Release date: 2008-09-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases. J.Am.Chem.Soc., 130, 2008
3B7O	Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site Descriptor: D-MALATE, Tyrosine-protein phosphatase non-receptor type 11 Authors: Ugochukwu, E, Barr, A, Patel, A, King, O, Niesen, F, Salah, E, Savitsky, P, Pilka, E.S, Elkins, J, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2007-10-31 Release date: 2007-11-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell(Cambridge,Mass.), 136, 2009
3BLU	crystal structure YopH complexed with inhibitor PVS Descriptor: (ethenylsulfonyl)benzene, Tyrosine-protein phosphatase yopH Authors: Liu, S, Zhang, Z.-Y. Deposit date: 2007-12-11 Release date: 2008-10-21 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases J.Am.Chem.Soc., 130, 2008
3D42	Crystal structure of HePTP in complex with a monophosphorylated Erk2 peptide Descriptor: D(-)-TARTARIC ACID, GLYCEROL, Mitogen-activated protein kinase 1 peptide, ... Authors: Critton, D.A, Tortajada, A, Page, R. Deposit date: 2008-05-13 Release date: 2009-03-17 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Structural basis of substrate recognition by hematopoietic tyrosine phosphatase. Biochemistry, 47, 2008
1A5Y	PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE Descriptor: PROTEIN TYROSINE PHOSPHATASE 1B Authors: Pannifer, A.D.P, Flint, A.J, Tonks, N.K, Barford, D. Deposit date: 1998-02-19 Release date: 1998-06-17 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography. J.Biol.Chem., 273, 1998
1AAX	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES Descriptor: 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN, MAGNESIUM ION, PROTEIN TYROSINE PHOSPHATASE 1B Authors: Puius, Y.A, Zhao, Y, Sullivan, M, Lawrence, D, Almo, S.C, Zhang, Z.-Y. Deposit date: 1997-01-16 Release date: 1998-03-04 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc.Natl.Acad.Sci.USA, 94, 1997
3BM8	crystal structure of YopH mutant D356A complexed with irreversible inhibitor PVSN Descriptor: Tyrosine-protein phosphatase yopH, phenyl ethenesulfonate Authors: Zhang, Z.Y, Liu, S.J. Deposit date: 2007-12-12 Release date: 2008-06-17 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases. J.Am.Chem.Soc., 130, 2008
3D44	Crystal structure of HePTP in complex with a dually phosphorylated Erk2 peptide mimetic Descriptor: CHLORIDE ION, GLYCEROL, Mitogen-activated protein kinase 1 peptide, ... Authors: Critton, D.A, Tortajada, A, Page, R. Deposit date: 2008-05-13 Release date: 2009-03-17 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis of substrate recognition by hematopoietic tyrosine phosphatase. Biochemistry, 47, 2008
3A5K	Crystal structure of protein-tyrosine phosphatase 1B Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 Authors: Ito, S. Deposit date: 2009-08-08 Release date: 2010-08-11 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Post-translational modification of a non-catalytic Cys121 of PTP1B To be Published
3EAX	Crystal structure PTP1B complex with small molecule compound LZP-6 Descriptor: 4,4'-piperazine-1,4-diylbis{1-[3-(benzyloxy)phenyl]-4-oxobutane-1,3-dione}, Tyrosine-protein phosphatase non-receptor type 1 Authors: Zhang, Z.-Y, Liu, S, Zhang, L.-F, Yu, X, Xue, T, Gunawan, A.M, Long, Y.-Q. Deposit date: 2008-08-26 Release date: 2009-07-07 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. J.Am.Chem.Soc., 130, 2008
4PVG	Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79 Descriptor: 2-[3-({4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutanoyl}amino)phenyl]-6-hydroxy-3-iodo-1-methyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Z.-Y, Zeng, L, Liu, D, Yu, Z. Deposit date: 2014-03-17 Release date: 2015-04-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of protein tyrosine Shp2 catalytic domain complex with compound L88N79 To be Published
4QAP	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. Deposit date: 2014-05-05 Release date: 2015-02-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.903 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014

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