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6YII
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BU of 6yii by Molmil
Crystal structure of a Class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ...
Authors:Moniot, S, Steegborn, C.
Deposit date:2020-04-01
Release date:2020-06-17
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Crystal structure of a class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa.
J.Struct.Biol., 211, 2020
7D9R
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BU of 7d9r by Molmil
Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state
Descriptor: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ...
Authors:Chen, L, Liu, R, Kang, Y.
Deposit date:2020-10-14
Release date:2021-08-11
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
7D9S
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BU of 7d9s by Molmil
Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state
Descriptor: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ...
Authors:Chen, L, Liu, R, Kang, Y.
Deposit date:2020-10-14
Release date:2021-08-11
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
7D9T
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BU of 7d9t by Molmil
Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state
Descriptor: 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1
Authors:Chen, L, Liu, R, Kang, Y.
Deposit date:2020-10-14
Release date:2021-08-11
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
7D9U
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BU of 7d9u by Molmil
Structure of human soluble guanylate cyclase in the cinciguat-bound activated state
Descriptor: 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ...
Authors:Chen, L, Liu, R, Kang, Y.
Deposit date:2020-10-14
Release date:2021-08-11
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
7OVD
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BU of 7ovd by Molmil
Human soluble adenylyl cyclase in complex with the inhibitor TDI10229
Descriptor: 1,2-ETHANEDIOL, 4-chloranyl-6-[1,5-dimethyl-4-(phenylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ...
Authors:Steegborn, C, Quast, J.
Deposit date:2021-06-14
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
Acs Med.Chem.Lett., 12, 2021
7PD4
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BU of 7pd4 by Molmil
structure of Adenylyl cyclase 9 in complex with MANT-GTP
Descriptor: Adenylate cyclase 9
Authors:Qi, C, Korkhov, V.M.
Deposit date:2021-08-04
Release date:2022-01-19
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structural basis of adenylyl cyclase 9 activation.
Nat Commun, 13, 2022
7PD8
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BU of 7pd8 by Molmil
Structure of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP
Descriptor: Adenylate cyclase 9, DARPin C4
Authors:Qi, C, Korkhov, V.M.
Deposit date:2021-08-04
Release date:2022-01-19
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural basis of adenylyl cyclase 9 activation.
Nat Commun, 13, 2022
7PDD
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BU of 7pdd by Molmil
Focus refinement of soluble domain of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP
Descriptor: Adenylate cyclase 9, DARPin C4
Authors:Qi, C, Korkhov, V.M.
Deposit date:2021-08-05
Release date:2022-01-19
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural basis of adenylyl cyclase 9 activation.
Nat Commun, 13, 2022
7PDE
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BU of 7pde by Molmil
Structure of Adenylyl cyclase 9 in complex with Gs protein alpha subunit and MANT-GTP
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Qi, C, Korkhov, V.M.
Deposit date:2021-08-05
Release date:2022-01-19
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural basis of adenylyl cyclase 9 activation.
Nat Commun, 13, 2022
7PDF
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BU of 7pdf by Molmil
focus refinement of soluble domain of adenylyl cyclase 9 in complex with Gs protein alpha subunit and MANT-GTP
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase 9, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Qi, C, Korkhov, V.M.
Deposit date:2021-08-05
Release date:2022-01-26
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of adenylyl cyclase 9 activation.
Nat Commun, 13, 2022
7PDG
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BU of 7pdg by Molmil
structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS
Descriptor: Adenylate cyclase 9, DARPin C4
Authors:Qi, C, Korkhov, V.M.
Deposit date:2021-08-05
Release date:2022-01-19
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of adenylyl cyclase 9 activation.
Nat Commun, 13, 2022
7PDH
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BU of 7pdh by Molmil
structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS
Descriptor: Adenylate cyclase 9, DARPin C4
Authors:Qi, C, Korkhov, V.M.
Deposit date:2021-08-05
Release date:2022-01-19
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of adenylyl cyclase 9 activation.
Nat Commun, 13, 2022
7R65
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BU of 7r65 by Molmil
Crystal structure of a bacterial cyclic UMP synthase from Burkholderia cepacia LK29
Descriptor: Adenylate/guanylate cyclase
Authors:Morehouse, B.R, Kranzusch, P.J.
Deposit date:2021-06-22
Release date:2021-10-13
Last modified:2021-11-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.
Cell, 184, 2021
7YZ9
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BU of 7yz9 by Molmil
Structure of catalytic domain of Rv1625c bound to nanobody NB4
Descriptor: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, GLYCEROL, ...
Authors:Khanppnavar, B, Mehta, V.J, Iype, T, Korkhov, V.M.
Deposit date:2022-02-19
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases.
Elife, 11, 2022
7YZI
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BU of 7yzi by Molmil
Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya
Descriptor: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, MANGANESE (II) ION, ...
Authors:Mehta, V, Khanppnavar, B, Korkhov, V.M.
Deposit date:2022-02-20
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (3.83 Å)
Cite:Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases.
Elife, 11, 2022
7YZK
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BU of 7yzk by Molmil
Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya
Descriptor: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, MANGANESE (II) ION, ...
Authors:Mehta, V, Khanppnavar, B, Korkhov, V.M.
Deposit date:2022-02-20
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases.
Elife, 11, 2022
8B75
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BU of 8b75 by Molmil
CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLYL CYCLASE IN COMPLEX WITH THE INHIBITOR TDI-011861
Descriptor: Adenylate cyclase type 10, [(3~{R})-4-[2-[2-[[3-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-1-[bis(fluoranyl)methyl]pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol
Authors:Steegborn, C, Kehr, M.
Deposit date:2022-09-28
Release date:2023-03-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
J.Med.Chem., 65, 2022
8BUZ
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BU of 8buz by Molmil
Structure of Adenylyl cyclase 8 bound to stimulatory G-protein, Ca2+/Calmodulin, Forskolin and MANT-GTP
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ...
Authors:Khanppnavar, B, Korkhov, V.M, Mehta, V.
Deposit date:2022-12-01
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of Adenylyl cyclase 8 bound to stimulatory G-protein, Ca2+/Calmodulin, Forskolin and MANT-GTP
To Be Published
8BV5
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BU of 8bv5 by Molmil
Focus refinement of soluble domain of Adenylyl cyclase 8 bound to stimulatory G protein, Forskolin, ATPalphaS, and Ca2+/Calmodulin in lipid nanodisc conditions
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ...
Authors:Khanppnavar, B, Korkhov, V.M.
Deposit date:2023-01-04
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Focused refinement of the soluble domain of Adenylyl cyclase 8 bound to stimulatory G protein, Forskolin, ATPalphaS, and Ca2+/Calmodulin in lipid nanodisc
To Be Published
8CNH
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BU of 8cnh by Molmil
Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-10512
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Adenylate cyclase type 10, ...
Authors:Steegborn, C.
Deposit date:2023-02-23
Release date:2023-04-26
Last modified:2023-05-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
J.Chem.Inf.Model., 63, 2023
8CO7
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BU of 8co7 by Molmil
Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-09066
Descriptor: 1,2-ETHANEDIOL, 4-chloranyl-6-[1-methyl-4-(thiophen-2-ylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ...
Authors:Steegborn, C.
Deposit date:2023-02-27
Release date:2024-01-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
J.Chem.Inf.Model., 63, 2023
8COJ
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BU of 8coj by Molmil
Crystal structure of human soluble adenylyl cyclase catalytic domain in complex with the inhibitor TDI-10228
Descriptor: 1,2-ETHANEDIOL, 4-chloranyl-6-[4-[(3-fluorophenyl)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ...
Authors:Steegborn, C, Fushimi, M.
Deposit date:2023-02-28
Release date:2023-04-26
Last modified:2023-05-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
J.Chem.Inf.Model., 63, 2023
8COT
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BU of 8cot by Molmil
Complex of human soluble adenylyl cyclase 10 catalytic core with inhibitor TDI-10962
Descriptor: 1,2-ETHANEDIOL, 2-(dimethylamino)ethyl 5-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-2-methyl-4-(phenylmethyl)pyrazole-3-carboxylate, ACETATE ION, ...
Authors:Steegborn, C, Fushimi, M.
Deposit date:2023-02-28
Release date:2023-04-26
Last modified:2023-05-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
J.Chem.Inf.Model., 63, 2023
8FX4
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BU of 8fx4 by Molmil
GC-C-Hsp90-Cdc37 regulatory complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Guanylyl cyclase C, Heat shock protein HSP 90-beta, ...
Authors:Caveney, N.A, Garcia, K.C.
Deposit date:2023-01-23
Release date:2023-07-12
Last modified:2023-08-23
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.
Elife, 12, 2023

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