7OVD

Human soluble adenylyl cyclase in complex with the inhibitor TDI10229

Summary for 7OVD

• Entry DOI: 10.2210/pdb7ovd/pdb
• Descriptor: Adenylate cyclase type 10, 4-chloranyl-6-[1,5-dimethyl-4-(phenylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... (6 entities in total)
• Functional Keywords: soluble adenylyl cyclase, adcy10, signaling enzyme, class iii cyclase, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 55504.57

Authors

Steegborn, C.,Quast, J. (deposition date: 2021-06-14, release date: 2021-10-06, Last modification date: 2024-01-31)

• Primary citation: Fushimi, M.,Buck, H.,Balbach, M.,Gorovyy, A.,Ferreira, J.,Rossetti, T.,Kaur, N.,Levin, L.R.,Buck, J.,Quast, J.,van den Heuvel, J.,Steegborn, C.,Finkin-Groner, E.,Kargman, S.,Michino, M.,Foley, M.A.,Miller, M.,Liverton, N.J.,Huggins, D.J.,Meinke, P.T.; Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).; Acs Med.Chem.Lett., 12:1283-1287, 2021; PubMed: 34413957; DOI: 10.1021/acsmedchemlett.1c00273

Experimental method

X-RAY DIFFRACTION (2.2 Å)