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8GWE	SARS-CoV-2 E-RTC complex with RNA-nsp9 and GMPPNP Descriptor: Helicase nsp13, MAGNESIUM ION, Non-structural protein 8, ... Authors: Yan, L.M, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-16 Release date: 2023-01-11 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (2.66 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWO	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: Helicase, Non-structural protein 7, Non-structural protein 8, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-11-30 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWI	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-12-14 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWF	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... Authors: Yan, L.Y, Huang, Y.C, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2023-01-11 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWG	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-12-14 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWN	A mechanism for SARS-CoV-2 RNA capping and its inhibitor of AT-527 Descriptor: Helicase, Non-structural protein 7, Non-structural protein 8, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-12-14 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
5N8X	Trigonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus Descriptor: 3D polymerase, GLYCEROL, MANGANESE (II) ION Authors: Ferrer-Orta, C, Verdaguer, N. Deposit date: 2017-02-24 Release date: 2017-05-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus. Genome Biol Evol, 9, 2017
7F0R	Cryo-EM structure of Pseudomonas aeruginosa SutA transcription activation complex Descriptor: DNA (70-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: He, D.W, You, L.L, Zhang, Y. Deposit date: 2021-06-06 Release date: 2022-07-27 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
5FJ7	Structure of the P2 polymerase inside in vitro assembled bacteriophage phi6 polymerase complex, with P1 included Descriptor: MAJOR INNER PROTEIN P1, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE Authors: Ilca, S, Kotecha, A, Sun, X, Poranen, M.P, Stuart, D.I, Huiskonen, J.T. Deposit date: 2015-10-06 Release date: 2015-11-04 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (7.9 Å) Cite: Localized Reconstruction of Subunits from Electron Cryomicroscopy Images of Macromolecular Complexes. Nat.Commun., 6, 2015
8QJ7	Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ... Authors: Yin, Z, Pellegrini, L. Deposit date: 2023-09-12 Release date: 2024-02-21 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.07 Å) Cite: CryoEM insights into RNA primer synthesis by the human primosome. Febs J., 291, 2024
5FJ6	Structure of the P2 polymerase inside in vitro assembled bacteriophage phi6 polymerase complex Descriptor: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE Authors: Ilca, S, Kotecha, A, Sun, X, Poranen, M.P, Stuart, D.I, Huiskonen, J.T. Deposit date: 2015-10-06 Release date: 2015-11-04 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (7.9 Å) Cite: Localized Reconstruction of Subunits from Electron Cryomicroscopy Images of Macromolecular Complexes. Nat.Commun., 6, 2015
7ORM	La Crosse virus polymerase at transcription early-elongation stage Descriptor: MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3'), RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*C)-3'), ... Authors: Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. Deposit date: 2021-06-06 Release date: 2022-02-16 Last modified: 2022-03-02 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription. Nat Commun, 13, 2022
3J7P	Structure of the 80S mammalian ribosome bound to eEF2 Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... Authors: Voorhees, R.M, Fernandez, I.S, Scheres, S.H.W, Hegde, R.S. Deposit date: 2014-08-01 Release date: 2014-09-03 Last modified: 2018-07-18 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution. Cell(Cambridge,Mass.), 157, 2014
3Q23	X-ray crystal structure of the N4 mini-VRNAP and P2_7a promoter transcription initiation complex with GMPCPP and Manganese: sustrate complex II Descriptor: DIHYDROGENPHOSPHATE ION, DNA (5'-D(*TP*GP*CP*CP*TP*CP*CP*CP*AP*GP*GP*CP*AP*TP*CP*CP*AP*AP*AP*AP*GP*AP*AP*GP*CP*GP*GP*AP*GP*CP*TP*TP*CP*TP*TP*C)-3'), MANGANESE (II) ION, ... Authors: Gleghorn, M.L, Murakami, K.S. Deposit date: 2010-12-19 Release date: 2011-02-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.8 Å) Cite: X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides. Proc.Natl.Acad.Sci.USA, 108, 2011
7EGQ	Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading Descriptor: Helicase, MAGNESIUM ION, Non-structural protein 10, ... Authors: Yan, L.M, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2021-03-25 Release date: 2021-07-21 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell, 184, 2021
8FYH	G4 RNA-mediated PRC2 dimer Descriptor: G4 RNA, Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, ... Authors: Song, J, Kasinath, V. Deposit date: 2023-01-26 Release date: 2023-10-04 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science, 381, 2023
7EIZ	Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading Descriptor: Helicase, MAGNESIUM ION, Non-structural protein 10, ... Authors: Yan, L, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2021-04-01 Release date: 2021-09-22 Last modified: 2023-07-26 Method: ELECTRON MICROSCOPY Cite: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading Cell, 184, 2021
8CWT	Complex structure of WhiB3 and the SigmaAr4-RNAP Beta flap tip chimera in space group P43212 Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IRON/SULFUR CLUSTER, NICKEL (II) ION, ... Authors: Wan, T, Zhang, L. Deposit date: 2022-05-19 Release date: 2023-05-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis. J.Biol.Chem., 299, 2023
8CWR	Complex structure of WhiB3 and the SigmaAr4-RNAP Beta flap tip chimera in space group R3 Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IRON/SULFUR CLUSTER, NICKEL (II) ION, ... Authors: Wan, T, Zhang, L. Deposit date: 2022-05-19 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis. J.Biol.Chem., 299, 2023
7BEG	Structures of class I bacterial transcription complexes Descriptor: Class I pacrA promoter non-template DNA, Class I pacrA promoter template DNA, DNA-directed RNA polymerase subunit alpha, ... Authors: Ye, F.Z, Hao, M, Zhang, X.D. Deposit date: 2020-12-23 Release date: 2021-12-01 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA-Dependent Transcription Activation. Adv Sci, 9, 2022
8GWK	SARS-CoV-2 RNA E-RTC complex with RMP-nsp9 and GMPPNP Descriptor: Helicase, MAGNESIUM ION, Non-structural protein 7, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2024-02-28 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
4AWH	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with rUMP Descriptor: MANGANESE (II) ION, POLYMERASE PA, URIDINE-5'-MONOPHOSPHATE Authors: Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. Deposit date: 2012-06-03 Release date: 2012-08-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
4AVG	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 2 Descriptor: (Z)-4-[4-[(4-chlorophenyl)methyl]-1-(cyclohexylmethyl)piperidin-4-yl]-2-oxidanyl-4-oxidanylidene-but-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA Authors: Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. Deposit date: 2012-05-25 Release date: 2012-08-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
4AWG	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 3 Descriptor: (2Z)-4-[(3S)-1-benzyl-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA, ... Authors: Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. Deposit date: 2012-06-03 Release date: 2012-08-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
4ZQQ	Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region Descriptor: MANGANESE (II) ION, Polymerase acidic protein,Polymerase acidic protein, SULFATE ION Authors: Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Neya, S, Hoshino, T. Deposit date: 2015-05-11 Release date: 2015-06-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit. Biochemistry, 55, 2016

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