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7W3P
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BU of 7w3p by Molmil
Crystal structure of RORgamma in complex with natural inverse agonist
Descriptor: (3S,5R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol, Nuclear receptor ROR-gamma, Peptide from Nuclear receptor coactivator 2
Authors:Tian, S.Y, Li, Y.
Deposit date:2021-11-25
Release date:2022-12-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of RORgamma in complex with natural inverse agonist
To Be Published
7SSA
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BU of 7ssa by Molmil
Cryo-EM structure of pioneer factor Cbf1 bound to the nucleosome
Descriptor: Centromere-binding protein 1, DNA (137-MER), Histone H2A.1, ...
Authors:Eek, P, Tan, S.
Deposit date:2021-11-10
Release date:2023-04-05
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions.
Mol.Cell, 83, 2023
7Q5X
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BU of 7q5x by Molmil
HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-2 ALPHA CODD (523-542)
Descriptor: 2-OXOGLUTARIC ACID, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Figg Jr, W.D, McDonough, M.A, Chowdhury, R, Nakashima, Y, Schofield, C.J.
Deposit date:2021-11-04
Release date:2022-11-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2 alpha to prolyl hydroxylase domain 2.
Proteins, 91, 2023
7Q5V
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BU of 7q5v by Molmil
HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) IN COMPLEX WITH N-OXALYLGLYCINE (NOG) AND HIF-2 ALPHA CODD (523-542)
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Egl nine homolog 1, ...
Authors:Figg Jr, W.D, McDonough, M.A, Chowdhury, R, Nakashima, Y, Schofield, C.J.
Deposit date:2021-11-04
Release date:2022-11-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2 alpha to prolyl hydroxylase domain 2.
Proteins, 91, 2023
7VNI
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BU of 7vni by Molmil
AHR-ARNT PAS-B heterodimer
Descriptor: Ahr homolog spineless, Aryl hydrocarbon receptor nuclear translocator, SULFATE ION
Authors:Dai, S.Y.
Deposit date:2021-10-11
Release date:2022-04-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor.
Nat Commun, 13, 2022
7VNH
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BU of 7vnh by Molmil
drosophlia AHR PAS-B domain bound by the antagonist alpha-naphthoflavone
Descriptor: 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE, Ahr homolog spineless
Authors:Dai, S.Y.
Deposit date:2021-10-11
Release date:2022-04-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor.
Nat Commun, 13, 2022
7VNA
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BU of 7vna by Molmil
drosophlia AHR PAS-B domain
Descriptor: Ahr homolog spineless
Authors:Dai, S.Y.
Deposit date:2021-10-10
Release date:2022-04-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.597 Å)
Cite:Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor.
Nat Commun, 13, 2022
7V7L
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BU of 7v7l by Molmil
Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex
Descriptor: Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha
Authors:Diao, X, Ren, X, Li, F.W, Sun, X, Wu, D.
Deposit date:2021-08-21
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha.
Nat Commun, 13, 2022
7PDT
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BU of 7pdt by Molmil
Crystal structure of a mutated form of RXRalpha ligand binding domain in complex with BMS649 and a coactivator fragment
Descriptor: 4-[2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-[1,3]DIOXOLAN-2-YL]-BENZOIC ACID, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha
Authors:le Maire, A, Bourguet, W, Guee, L.
Deposit date:2021-08-07
Release date:2022-08-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids.
J.Mol.Endocrinol., 69, 2022
7PDQ
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BU of 7pdq by Molmil
Crystal structure of a mutated form of RXRalpha ligand binding domain in complex with LG100268 and a coactivator fragment
Descriptor: 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha
Authors:le Maire, A, Bourguet, W, Guee, L.
Deposit date:2021-08-06
Release date:2022-08-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids.
J.Mol.Endocrinol., 69, 2022
7FDO
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BU of 7fdo by Molmil
Crystal structure of transcription factor CPC in complex with EGL3
Descriptor: CHLORIDE ION, SULFATE ION, Transcription factor CPC, ...
Authors:Wang, B, Luo, Q.
Deposit date:2021-07-17
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:Structural insights into partner selection for MYB and bHLH transcription factor complexes.
Nat.Plants, 8, 2021
7FDN
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BU of 7fdn by Molmil
Crystal structure of transcription factor WER in complex with EGL3
Descriptor: CHLORIDE ION, GLYCEROL, SODIUM ION, ...
Authors:Luo, Q, Wang, B.
Deposit date:2021-07-17
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into partner selection for MYB and bHLH transcription factor complexes.
Nat.Plants, 8, 2021
7FDM
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BU of 7fdm by Molmil
Crystal structure of transcription factor MYB29 in complex with MYC3
Descriptor: Transcription factor MYB29, Transcription factor MYC3
Authors:Luo, Q, Wang, B.
Deposit date:2021-07-17
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into partner selection for MYB and bHLH transcription factor complexes.
Nat.Plants, 8, 2021
7FDL
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BU of 7fdl by Molmil
Crystal structure of transcription factor WER in complex with EGL3
Descriptor: Transcription factor EGL1, Transcription factor WER
Authors:Luo, Q, Wang, B.
Deposit date:2021-07-17
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.897 Å)
Cite:Structural insights into partner selection for MYB and bHLH transcription factor complexes.
Nat.Plants, 8, 2021
7RCU
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BU of 7rcu by Molmil
Synthetic Max homodimer mimic in complex with DNA
Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 2-(2,5-dioxopyrrolidin-1-yl)acetamide, ACETAMIDE, ...
Authors:Speltz, T, Qiao, Z, Shangguan, S, Fanning, S, Greene, J, Moellering, R.
Deposit date:2021-07-08
Release date:2022-09-14
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains.
Nat.Biotechnol., 41, 2023
7OY4
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BU of 7oy4 by Molmil
VDR complex of a side-chain hydroxylated derivatives of lithocholic acid
Descriptor: (3S,6R)-6-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(2-methyl-2-oxidanyl-propyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]heptane-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A
Authors:Rochel, N.
Deposit date:2021-06-23
Release date:2021-09-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis and evaluation of side-chain hydroxylated derivatives of lithocholic acid as potent agonists of the vitamin D receptor (VDR).
Bioorg.Chem., 115, 2021
7OXZ
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BU of 7oxz by Molmil
VDR complex with a side-chain hydroxylated derivative of lithocholic acid
Descriptor: (3R,6R)-6-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(2-methyl-2-oxidanyl-propyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]heptane-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A
Authors:Rochel, N.
Deposit date:2021-06-23
Release date:2021-09-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design, synthesis and evaluation of side-chain hydroxylated derivatives of lithocholic acid as potent agonists of the vitamin D receptor (VDR).
Bioorg.Chem., 115, 2021
7F2F
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BU of 7f2f by Molmil
The complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae.
Descriptor: DNA (5'-D(*CP*AP*GP*AP*TP*CP*AP*TP*GP*TP*GP*TP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*CP*AP*CP*AP*CP*AP*TP*GP*AP*TP*CP*T)-3'), Serine-rich protein TYE7
Authors:Gui, W.
Deposit date:2021-06-10
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of the complex of DNA with the C-terminal domain of TYE7 from Saccharomyces cerevisiae.
Acta Crystallogr.,Sect.F, 77, 2021
7F09
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BU of 7f09 by Molmil
Crystal structure of the HLH-Lz domain of human TFE3
Descriptor: 1,2-ETHANEDIOL, Transcription factor E3, ZINC ION
Authors:Yang, G, Li, P, Liu, Z, Wu, S, Zhuang, C, Qiao, H, Fang, P, Wang, J.
Deposit date:2021-06-03
Release date:2021-07-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the dimerization mechanism of human transcription factor E3.
Biochem.Biophys.Res.Commun., 569, 2021
7OFK
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BU of 7ofk by Molmil
Ligand complex of RORg LBD
Descriptor: (1~{R})-2-ethanoyl-~{N}-[4-[1,1,1,3,3,3-hexakis(fluoranyl)-2-oxidanyl-propan-2-yl]phenyl]-5-methylsulfonyl-1,3-dihydroisoindole-1-carboxamide, DIMETHYL SULFOXIDE, Nuclear receptor ROR-gamma, ...
Authors:Xue, Y, Aagaard, A, Narjes, F.
Deposit date:2021-05-05
Release date:2022-03-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.
J.Med.Chem., 64, 2021
7OFI
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BU of 7ofi by Molmil
Ligand complex of RORg LBD
Descriptor: (2~{R})-2-(4-ethylsulfonylphenyl)-~{N}-[4-[1,1,1,3,3,3-hexakis(fluoranyl)-2-oxidanyl-propan-2-yl]phenyl]-~{N}'-methyl-butanediamide, DIMETHYL SULFOXIDE, Nuclear receptor ROR-gamma, ...
Authors:Xue, Y, Aagaard, A, Narjes, F.
Deposit date:2021-05-05
Release date:2022-03-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.953 Å)
Cite:AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.
J.Med.Chem., 64, 2021
7EOD
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BU of 7eod by Molmil
MITF HLHLZ Delta AKE
Descriptor: GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor
Authors:Li, P, Liu, Z, Fang, P, Wang, J.
Deposit date:2021-04-22
Release date:2022-04-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
7LVS
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BU of 7lvs by Molmil
The CBP TAZ1 Domain in Complex with a CITED2-HIF-1-Alpha Fusion Peptide
Descriptor: Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone lysine acetyltransferase CREBBP, ZINC ION
Authors:Appling, F.D, Berlow, R.B, Stanfield, R.L, Dyson, H.J, Wright, P.E.
Deposit date:2021-02-26
Release date:2021-07-28
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The molecular basis of allostery in a facilitated dissociation process.
Structure, 29, 2021
7NKE
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BU of 7nke by Molmil
Crystal structure of human RXRalpha ligand binding domain in complex with 2,4-di-tert-butylphenol and a coactivator fragment
Descriptor: 2,4-di~{tert}-butylphenol, FORMIC ACID, Nuclear receptor coactivator 2, ...
Authors:Carivenc, C, Bourguet, W.
Deposit date:2021-02-17
Release date:2022-03-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors.
Endocrinology, 164, 2023
7NFB
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BU of 7nfb by Molmil
ER-PRS*(+) (Y537S) in complex with genistein and SRC-2 coactivator peptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Estrogen receptor, ...
Authors:Kriegel, M, Muller, Y.A.
Deposit date:2021-02-05
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:A PROSS-designed extensively mutated estrogen receptor alpha variant displays enhanced thermal stability while retaining native allosteric regulation and structure.
Sci Rep, 11, 2021

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