7OXZ

VDR complex with a side-chain hydroxylated derivative of lithocholic acid

Summary for 7OXZ

• Entry DOI: 10.2210/pdb7oxz/pdb
• Descriptor: Vitamin D3 receptor A, Nuclear receptor coactivator 1, (3R,6R)-6-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(2-methyl-2-oxidanyl-propyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]heptane-1,3-diol, ... (4 entities in total)
• Functional Keywords: nuclear recptor, agonist, transcription
• Biological source: Danio rerio (Zebrafish); More
• Total number of polymer chains: 2
• Total formula weight: 36299.49

Authors

Rochel, N. (deposition date: 2021-06-23, release date: 2021-09-01, Last modification date: 2024-01-31)

• Primary citation: Gonzalez, C.M.,Gaikwad, S.,Lasanta, G.,Loureiro, J.,Nilsson, N.,Peluso-Iltis, C.,Rochel, N.,Mourino, A.; Design, synthesis and evaluation of side-chain hydroxylated derivatives of lithocholic acid as potent agonists of the vitamin D receptor (VDR).; Bioorg.Chem., 115:105202-105202, 2021; PubMed: 34339974; DOI: 10.1016/j.bioorg.2021.105202

Experimental method

X-RAY DIFFRACTION (2.2 Å)