7NKE
Crystal structure of human RXRalpha ligand binding domain in complex with 2,4-di-tert-butylphenol and a coactivator fragment
Summary for 7NKE
Entry DOI | 10.2210/pdb7nke/pdb |
Descriptor | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 2,4-di~{tert}-butylphenol, ... (5 entities in total) |
Functional Keywords | nuclear receptor, complex, ligand, coactivator, gene regulation |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 58157.43 |
Authors | Carivenc, C.,Bourguet, W. (deposition date: 2021-02-17, release date: 2022-03-02, Last modification date: 2024-02-07) |
Primary citation | Ren, X.M.,Chang, R.C.,Huang, Y.,Amorim Amato, A.,Carivenc, C.,Grimaldi, M.,Kuo, Y.,Balaguer, P.,Bourguet, W.,Blumberg, B. 2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors. Endocrinology, 164:-, 2023 Cited by PubMed: 36750942DOI: 10.1210/endocr/bqad021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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