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7NKE

Crystal structure of human RXRalpha ligand binding domain in complex with 2,4-di-tert-butylphenol and a coactivator fragment

Summary for 7NKE
Entry DOI10.2210/pdb7nke/pdb
DescriptorRetinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 2,4-di~{tert}-butylphenol, ... (5 entities in total)
Functional Keywordsnuclear receptor, complex, ligand, coactivator, gene regulation
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight58157.43
Authors
Carivenc, C.,Bourguet, W. (deposition date: 2021-02-17, release date: 2022-03-02, Last modification date: 2024-02-07)
Primary citationRen, X.M.,Chang, R.C.,Huang, Y.,Amorim Amato, A.,Carivenc, C.,Grimaldi, M.,Kuo, Y.,Balaguer, P.,Bourguet, W.,Blumberg, B.
2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors.
Endocrinology, 164:-, 2023
Cited by
PubMed: 36750942
DOI: 10.1210/endocr/bqad021
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

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