7NKE
Crystal structure of human RXRalpha ligand binding domain in complex with 2,4-di-tert-butylphenol and a coactivator fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Retinoic acid receptor RXR-alpha | polymer | 244 | 27269.5 | 2 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B, D (B, D) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | E, F (A, C) | 2,4-di~{tert}-butylphenol | non-polymer | 206.3 | 2 | Chemie (UGW) | |||
| 4 | G (C) | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
| 5 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A, C: 223 - 462 (UniProt: P19793)
| PDB | External Database | Details |
|---|---|---|
| Gly 219 | - | expression tag |
| Ser 220 | - | expression tag |
| His 221 | - | expression tag |
| Met 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57698.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 458.7 | |
| All* | Total formula weight | 58157.4 |
