7PDT

Crystal structure of a mutated form of RXRalpha ligand binding domain in complex with BMS649 and a coactivator fragment

Summary for 7PDT

Entry DOI	10.2210/pdb7pdt/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 4-[2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-[1,3]DIOXOLAN-2-YL]-BENZOIC ACID, ... (4 entities in total)
Functional Keywords	nuclear hormone receptor, ligand binding, nuclear protein
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	4
Total formula weight	58299.36
Authors	le Maire, A.,Bourguet, W.,Guee, L. (deposition date: 2021-08-07, release date: 2022-08-03, Last modification date: 2024-01-31)
Primary citation	le Maire, A.,Rey, M.,Vivat, V.,Guee, L.,Blanc, P.,Malosse, C.,Chamot-Rooke, J.,Germain, P.,Bourguet, W. Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids. J.Mol.Endocrinol., 69:377-390, 2022 Cited by PubMed: 35900852 DOI: 10.1530/JME-22-0021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation