7PDT
Crystal structure of a mutated form of RXRalpha ligand binding domain in complex with BMS649 and a coactivator fragment
Summary for 7PDT
Entry DOI | 10.2210/pdb7pdt/pdb |
Descriptor | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 4-[2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-[1,3]DIOXOLAN-2-YL]-BENZOIC ACID, ... (4 entities in total) |
Functional Keywords | nuclear hormone receptor, ligand binding, nuclear protein |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 4 |
Total formula weight | 58299.36 |
Authors | le Maire, A.,Bourguet, W.,Guee, L. (deposition date: 2021-08-07, release date: 2022-08-03, Last modification date: 2024-01-31) |
Primary citation | le Maire, A.,Rey, M.,Vivat, V.,Guee, L.,Blanc, P.,Malosse, C.,Chamot-Rooke, J.,Germain, P.,Bourguet, W. Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids. J.Mol.Endocrinol., 69:377-390, 2022 Cited by PubMed: 35900852DOI: 10.1530/JME-22-0021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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