7PDT
Crystal structure of a mutated form of RXRalpha ligand binding domain in complex with BMS649 and a coactivator fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Retinoic acid receptor RXR-alpha | polymer | 245 | 27190.3 | 2 | UniProt (P28700) Pfam (PF00104) | Mus musculus (Mouse) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B, D (U, V) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | E, F (A, B) | 4-[2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-[1,3]DIOXOLAN-2-YL]-BENZOIC ACID | non-polymer | 379.5 | 2 | Chemie (BM6) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A, B: 227 - 467 (UniProt: P28700)
| PDB | External Database | Details |
|---|---|---|
| Gly 223 | - | expression tag |
| Pro 224 | - | expression tag |
| His 225 | - | expression tag |
| Met 226 | - | expression tag |
| Ala 315 | Ile 315 | engineered mutation |
| Ala 318 | Phe 318 | engineered mutation |
| Thr 332 | Ala 332 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57540.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 758.9 | |
| All* | Total formula weight | 58299.4 |
