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6NVP
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Crystal structure of Pseudomonas putida nuclease MPE
Descriptor: MANGANESE (II) ION, Nuclease MPE
Authors:Goldgur, Y, Shuman, S, Ejaz, A.
Deposit date:2019-02-05
Release date:2019-03-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activity and structure ofPseudomonas putidaMPE, a manganese-dependent single-strand DNA endonuclease encoded in a nucleic acid repair gene cluster.
J.Biol.Chem., 294, 2019
6NVO
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BU of 6nvo by Molmil
Crystal structure of Pseudomonas putida nuclease MPE
Descriptor: MANGANESE (II) ION, Nuclease MPE
Authors:Goldgur, Y, Shuman, S, Ejaz, A.
Deposit date:2019-02-05
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:Activity and structure ofPseudomonas putidaMPE, a manganese-dependent single-strand DNA endonuclease encoded in a nucleic acid repair gene cluster.
J.Biol.Chem., 294, 2019
6UNC
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BU of 6unc by Molmil
The crystal structure of Phosphopantetheinyl Hydrolase (PptH) from Mycobacterium tuberculosis
Descriptor: FE (III) ION, MANGANESE (II) ION, Metallophos domain-containing protein
Authors:Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2019-10-11
Release date:2020-04-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis.
Protein Sci., 29, 2020
6UUQ
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BU of 6uuq by Molmil
Structure of Calcineurin bound to RCAN1
Descriptor: Calcipressin-1, FE (III) ION, PHOSPHATE ION, ...
Authors:Sheftic, S, Page, R, Peti, W.
Deposit date:2019-10-31
Release date:2020-09-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin.
Sci Adv, 6, 2020
6PIB
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BU of 6pib by Molmil
Structure of the Klebsiella pneumoniae LpxH-AZ1 complex
Descriptor: 1-[5-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one, MANGANESE (II) ION, TETRAETHYLENE GLYCOL, ...
Authors:Cho, J, Zhou, P.
Deposit date:2019-06-26
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics.
Proc.Natl.Acad.Sci.USA, 117, 2020
4NZV
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DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Descriptor: Exonuclease, putative, MANGANESE (II) ION
Authors:Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A.
Deposit date:2013-12-12
Release date:2014-01-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.
Mol.Cell, 53, 2014
4O24
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BU of 4o24 by Molmil
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Descriptor: (5~{Z})-5-[(4-hydroxyphenyl)methylidene]-3-(2-methylpropyl)-2-sulfanylidene-1,3-thiazolidin-4-one, Exonuclease, putative, ...
Authors:Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A.
Deposit date:2013-12-16
Release date:2014-01-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.
Mol.Cell, 53, 2014
4O4K
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BU of 4o4k by Molmil
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Descriptor: (5~{E})-2-azanylidene-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one, Exonuclease, putative, ...
Authors:Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A.
Deposit date:2013-12-18
Release date:2014-01-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.
Mol.Cell, 53, 2014
4O43
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BU of 4o43 by Molmil
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Descriptor: (5~{E})-3-[(2~{R})-butan-2-yl]-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, Exonuclease, putative, ...
Authors:Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A.
Deposit date:2013-12-18
Release date:2014-01-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.
Mol.Cell, 53, 2014
4O5G
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BU of 4o5g by Molmil
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Descriptor: (5~{E})-5-[(4-aminophenyl)methylidene]-2-azanylidene-1,3-thiazolidin-4-one, Exonuclease, putative, ...
Authors:Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A.
Deposit date:2013-12-19
Release date:2014-01-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.
Mol.Cell, 53, 2014
3GVE
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BU of 3gve by Molmil
Crystal structure of calcineurin-like phosphoesterase YfkN from Bacillus subtilis
Descriptor: CITRIC ACID, MAGNESIUM ION, MANGANESE (II) ION, ...
Authors:Kim, Y, Marshall, N, Cobb, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2009-03-30
Release date:2009-04-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal Structure of Calcineurin-like Phosphoesterase from Bacillus subtilis
To be Published
8QK5
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BU of 8qk5 by Molmil
Structure of K. pneumoniae LpxH in complex with EBL-3647
Descriptor: 5-[[3-(aminomethyl)azetidin-1-yl]methyl]-N-[4-[4-(4-cyano-6-methyl-pyrimidin-2-yl)piperazin-1-yl]sulfonylphenyl]-2-[methyl(methylsulfonyl)amino]benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase
Authors:Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
Deposit date:2023-09-14
Release date:2024-04-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc.Natl.Acad.Sci.USA, 121, 2024
8QJZ
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BU of 8qjz by Molmil
Crystal structure of E. coli LpxH in complex with lipid X
Descriptor: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase
Authors:Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
Deposit date:2023-09-14
Release date:2024-04-17
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc.Natl.Acad.Sci.USA, 121, 2024
8QKA
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BU of 8qka by Molmil
Structure of K. pneumoniae LpxH in complex with JEDI-852
Descriptor: 2-[methyl(methylsulfonyl)amino]-~{N}-(4-piperidin-1-ylsulfonylphenyl)benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase
Authors:Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
Deposit date:2023-09-14
Release date:2024-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc.Natl.Acad.Sci.USA, 121, 2024
8QK2
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BU of 8qk2 by Molmil
Structure of K.pneumoniae LpxH in complex with EBL-3339
Descriptor: MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase, ~{N}-[4-[4-(4-cyano-6-methyl-pyrimidin-2-yl)piperazin-1-yl]sulfonylphenyl]-2-[methyl(methylsulfonyl)amino]benzamide
Authors:Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
Deposit date:2023-09-14
Release date:2024-04-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc.Natl.Acad.Sci.USA, 121, 2024
8QK9
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BU of 8qk9 by Molmil
Structure of E. coli LpxH in complex with JEDI-1444
Descriptor: 2-[methyl(methylsulfonyl)amino]-~{N}-[4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonylphenyl]benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase
Authors:Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L.
Deposit date:2023-09-14
Release date:2024-04-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc.Natl.Acad.Sci.USA, 121, 2024
2USH
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BU of 2ush by Molmil
5'-NUCLEOTIDASE FROM E. COLI
Descriptor: 5'-NUCLEOTIDASE, TUNGSTATE(VI)ION, ZINC ION
Authors:Knofel, T, Strater, N.
Deposit date:1998-09-24
Release date:1999-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site.
Nat.Struct.Biol., 6, 1999
4Q7F
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BU of 4q7f by Molmil
1.98 Angstrom Crystal Structure of Putative 5'-Nucleotidase from Staphylococcus aureus in complex with Adenosine.
Descriptor: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, 5' nucleotidase family protein, MAGNESIUM ION, ...
Authors:Minasov, G, Nocadello, S, Shuvalova, L, Dubrovska, I, Winsor, J, Bagnoli, F, Falugi, F, Bottomley, M, Grandi, G, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2014-04-24
Release date:2014-05-07
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:1.98 Angstrom Crystal Structure of Putative 5'-Nucleotidase from Staphylococcus aureus in complex with Adenosine.
TO BE PUBLISHED
3N5U
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BU of 3n5u by Molmil
Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1
Descriptor: CHLORIDE ION, MANGANESE (II) ION, Retinoblastoma-associated protein, ...
Authors:Hirschi, A.M, Cecchini, M, Steinhardt, R.C, Dick, F.A, Rubin, S.M.
Deposit date:2010-05-25
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein.
Nat.Struct.Mol.Biol., 17, 2010
5JJT
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BU of 5jjt by Molmil
Crystal structure of a type 5 serine/threonine protein phosphatase from Arabidopsis thaliana
Descriptor: NICKEL (II) ION, Serine/threonine-protein phosphatase 5
Authors:Li, H.M, Pu, H.
Deposit date:2016-04-25
Release date:2017-04-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Crystal structure of a type 5 serine/threonine protein phosphatase from Arabidopsis thaliana
To Be Published
5JG8
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BU of 5jg8 by Molmil
Crystal structure of human acid sphingomyelinase
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Xiong, Z.J, Prive, G.G.
Deposit date:2016-04-19
Release date:2016-07-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis.
J.Mol.Biol., 428, 2016
7SOY
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BU of 7soy by Molmil
The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex
Descriptor: Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Protein phosphatase methylesterase 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Li, Y, Balakrishnan, V.K, Rowse, M, Novikova, I.V, Xing, Y.
Deposit date:2021-11-01
Release date:2022-08-31
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition.
Elife, 11, 2022
5SVE
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BU of 5sve by Molmil
Structure of Calcineurin in complex with NFATc1 LxVP peptide
Descriptor: CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ...
Authors:Sheftic, S.R, Page, R, Peti, W.
Deposit date:2016-08-05
Release date:2017-01-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Investigating the human Calcineurin Interaction Network using the pi LxVP SLiM.
Sci Rep, 6, 2016
7OBE
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BU of 7obe by Molmil
X-ray structure of the phosphatase PAPP5 from Arabidopsis thaliana
Descriptor: CHLORIDE ION, Isoform 2 of Serine/threonine-protein phosphatase 5, MANGANESE (II) ION
Authors:von Horsten, S, Essen, L.-O.
Deposit date:2021-04-22
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Conformational Change of Tetratricopeptide Repeats Region Triggers Activation of Phytochrome-Associated Protein Phosphatase 5.
Front Plant Sci, 12, 2021
5UI1
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BU of 5ui1 by Molmil
Crystal Structure of Human Protein Phosphatase 5C (PP5C) in complex with a triazole inhibitor
Descriptor: 5-phenyl-1H-1,2,3-triazole-4-carboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5
Authors:Chattopadhyay, D, Swingle, M.R, Salter, E.A, Banerjee, S, Honkanen, R.E.
Deposit date:2017-01-12
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structure Human PP5C in Complex with an Inhibitor
To Be Published

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