5EBE

Structure of human sphingomyelinase phosphodiesterase like 3A (SMPDL3A) with 5' CMP

Summary for 5EBE

Entry DOI	10.2210/pdb5ebe/pdb
Related	5EBB
Descriptor	Acid sphingomyelinase-like phosphodiesterase 3a, THIOCYANATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	calcineurin like phosphodiesterase, binuclear metallophosphodiesterase, acid sphingomyelinase like, hydrolase
Biological source	Homo sapiens (Human) More
Cellular location	Secreted : Q92484 Q92484
Total number of polymer chains	3
Total formula weight	146510.98
Authors	Lim, S.M.,Yeung, K.,Tresaugues, L.,Teo, H.L.,Nordlund, P. (deposition date: 2015-10-19, release date: 2016-01-20, Last modification date: 2024-01-10)
Primary citation	Lim, S.M.,Yeung, K.,Tresaugues, L.,Ling, T.H.,Nordlund, P. The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a - an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity. Febs J., 283:1107-1123, 2016 Cited by PubMed: 26783088 DOI: 10.1111/febs.13655 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation