5EBE
Structure of human sphingomyelinase phosphodiesterase like 3A (SMPDL3A) with 5' CMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004767 | molecular_function | sphingomyelin phosphodiesterase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | obsolete extracellular space |
| A | 0006685 | biological_process | sphingomyelin catabolic process |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009143 | biological_process | nucleoside triphosphate catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0017111 | molecular_function | ribonucleoside triphosphate phosphatase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
| B | 0004767 | molecular_function | sphingomyelin phosphodiesterase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | obsolete extracellular space |
| B | 0006685 | biological_process | sphingomyelin catabolic process |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009143 | biological_process | nucleoside triphosphate catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0017111 | molecular_function | ribonucleoside triphosphate phosphatase activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
| C | 0004767 | molecular_function | sphingomyelin phosphodiesterase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | obsolete extracellular space |
| C | 0006685 | biological_process | sphingomyelin catabolic process |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0009143 | biological_process | nucleoside triphosphate catabolic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0017111 | molecular_function | ribonucleoside triphosphate phosphatase activity |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26783088","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26783088","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26783088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28104755","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26783088","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28104755","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26783088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28104755","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
