7JV9

Human CD73 (ecto 5'-nucleotidase) in complex with compound 12

Summary for 7JV9

Entry DOI	10.2210/pdb7jv9/pdb
Descriptor	5'-nucleotidase, ZINC ION, CALCIUM ION, ... (7 entities in total)
Functional Keywords	5'-nucleotidase, hydrolase, phosphatase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	118625.37
Authors	Gibbons, P.,Du, X. (deposition date: 2020-08-20, release date: 2020-09-23, Last modification date: 2023-10-18)
Primary citation	Du, X.,Moore, J.,Blank, B.R.,Eksterowicz, J.,Sutimantanapi, D.,Yuen, N.,Metzger, T.,Chan, B.,Huang, T.,Chen, X.,Chen, Y.,Duong, F.,Kong, W.,Chang, J.H.,Sun, J.,Zavorotinskaya, T.,Ye, Q.,Junttila, M.R.,Ndubaku, C.,Friedman, L.S.,Fantin, V.R.,Sun, D. Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production. J.Med.Chem., 63:10433-10459, 2020 Cited by PubMed: 32865411 DOI: 10.1021/acs.jmedchem.0c01086 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation