7JV9
Human CD73 (ecto 5'-nucleotidase) in complex with compound 12
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 5'-nucleotidase | polymer | 525 | 58305.3 | 2 | UniProt (P21589) Pfam (PF00149) Pfam (PF02872) | Homo sapiens (Human) | 5'-NT,Ecto-5'-nucleotidase |
| 2 | C, D, I, J (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | E, K (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | F, L (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | G, M (A, B) | 6-chloro-N-[(2-chlorophenyl)methyl]-1-[5-O-(phosphonomethyl)-beta-D-ribofuranosyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine | non-polymer | 520.3 | 2 | Chemie (VPG) | |||
| 6 | H, N (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 7 | O, P (A, B) | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 549 (UniProt: P21589)
| PDB | External Database | Details |
|---|---|---|
| Ser 25 | - | expression tag |
| Met 26 | - | expression tag |
| Asp 53 | Asn 53 | engineered mutation |
| Asp 333 | Asn 333 | engineered mutation |
| Asp 403 | Asn 403 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 116610.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2014.7 | |
| All* | Total formula weight | 118625.4 |
