6DRK
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![BU of 6drk by Molmil](/molmil-images/mine/6drk) | Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, Apo state | Descriptor: | Transient receptor potential cation channel, subfamily M, member 2 | Authors: | Du, J, Lu, W, Huang, Y, Winkler, P, Sun, W. | Deposit date: | 2018-06-12 | Release date: | 2018-09-19 | Last modified: | 2018-10-10 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature, 562, 2018
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6DRJ
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![BU of 6drj by Molmil](/molmil-images/mine/6drj) | Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, ADPR/Ca2+ bound state | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, Transient receptor potential cation channel, ... | Authors: | Du, J, Lu, W, Huang, Y, Winkler, P, Sun, W. | Deposit date: | 2018-06-12 | Release date: | 2018-09-19 | Last modified: | 2018-10-10 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature, 562, 2018
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6DRC
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![BU of 6drc by Molmil](/molmil-images/mine/6drc) | High IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptor | Descriptor: | CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ... | Authors: | Hite, R.K, Paknejad, N. | Deposit date: | 2018-06-11 | Release date: | 2018-08-01 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.92 Å) | Cite: | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3. Nat. Struct. Mol. Biol., 25, 2018
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6DRA
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![BU of 6dra by Molmil](/molmil-images/mine/6dra) | Low IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptor | Descriptor: | CALCIUM ION, Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION | Authors: | Hite, R.K, Paknejad, N. | Deposit date: | 2018-06-11 | Release date: | 2018-08-01 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3. Nat. Struct. Mol. Biol., 25, 2018
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6DR2
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![BU of 6dr2 by Molmil](/molmil-images/mine/6dr2) | Ca2+-bound human type 3 1,4,5-inositol trisphosphate receptor | Descriptor: | CALCIUM ION, Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION | Authors: | Hite, R.K, Paknejad, N. | Deposit date: | 2018-06-11 | Release date: | 2018-07-18 | Last modified: | 2018-08-15 | Method: | ELECTRON MICROSCOPY (4.33 Å) | Cite: | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3. Nat. Struct. Mol. Biol., 25, 2018
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6DR0
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![BU of 6dr0 by Molmil](/molmil-images/mine/6dr0) | Class 5 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION | Authors: | Hite, R.K, Paknejad, N. | Deposit date: | 2018-06-11 | Release date: | 2018-08-01 | Last modified: | 2018-08-15 | Method: | ELECTRON MICROSCOPY (4.47 Å) | Cite: | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3. Nat. Struct. Mol. Biol., 25, 2018
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6DQZ
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![BU of 6dqz by Molmil](/molmil-images/mine/6dqz) | Class 4 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION | Authors: | Hite, R.K, Paknejad, N. | Deposit date: | 2018-06-11 | Release date: | 2018-08-01 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (6.01 Å) | Cite: | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3. Nat. Struct. Mol. Biol., 25, 2018
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6DQV
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![BU of 6dqv by Molmil](/molmil-images/mine/6dqv) | Class 2 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION | Authors: | Hite, R.K, Paknejad, N. | Deposit date: | 2018-06-11 | Release date: | 2018-08-01 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3. Nat. Struct. Mol. Biol., 25, 2018
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6DQS
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![BU of 6dqs by Molmil](/molmil-images/mine/6dqs) | Class 3 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION | Authors: | Hite, R.K, Paknejad, N. | Deposit date: | 2018-06-11 | Release date: | 2018-08-01 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (4.12 Å) | Cite: | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3. Nat. Struct. Mol. Biol., 25, 2018
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6DQN
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![BU of 6dqn by Molmil](/molmil-images/mine/6dqn) | Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION | Authors: | Hite, R.K, Paknejad, N. | Deposit date: | 2018-06-11 | Release date: | 2018-08-01 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3. Nat. Struct. Mol. Biol., 25, 2018
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6DQJ
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![BU of 6dqj by Molmil](/molmil-images/mine/6dqj) | Human type 3 1,4,5-inositol trisphosphate receptor in a ligand-free state | Descriptor: | Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION | Authors: | Hite, R.K, Paknejad, N. | Deposit date: | 2018-06-11 | Release date: | 2018-08-01 | Last modified: | 2018-08-15 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3. Nat. Struct. Mol. Biol., 25, 2018
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6DMW
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![BU of 6dmw by Molmil](/molmil-images/mine/6dmw) | |
6DMU
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![BU of 6dmu by Molmil](/molmil-images/mine/6dmu) | PI(4,5)P2 bound full-length rbTRPV5 | Descriptor: | Transient receptor potential cation channel subfamily V member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Hughes, T.E.T, Pumroy, R.A, Moiseenkova-Bell, V.Y. | Deposit date: | 2018-06-05 | Release date: | 2018-10-24 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural insights on TRPV5 gating by endogenous modulators. Nat Commun, 9, 2018
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6DMR
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![BU of 6dmr by Molmil](/molmil-images/mine/6dmr) | |
6D7X
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![BU of 6d7x by Molmil](/molmil-images/mine/6d7x) | Crystal Structure of Rat TRPV6*-Y466A- in complex with brominated 2-Aminoethoxydiphenyl borate (2-APB-Br) | Descriptor: | 2-aminoethyl (4-bromophenyl)phenylborinate, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, ... | Authors: | Singh, A.K, Saotome, K, McGoldrick, L.L, Sobolevsky, A.I. | Deposit date: | 2018-04-25 | Release date: | 2018-07-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB. Nat Commun, 9, 2018
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6D7V
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![BU of 6d7v by Molmil](/molmil-images/mine/6d7v) | Crystal Structure of Rat TRPV6*- in complex with brominated 2-Aminoethoxydiphenyl borate (2-APB-Br) | Descriptor: | 2-aminoethyl (4-bromophenyl)phenylborinate, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | Authors: | Singh, A.K, Saotome, K, McGoldrick, L.L, Sobolevsky, A.I. | Deposit date: | 2018-04-25 | Release date: | 2018-07-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.3 Å) | Cite: | Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB. Nat Commun, 9, 2018
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6D7T
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![BU of 6d7t by Molmil](/molmil-images/mine/6d7t) | Cryo-EM structure of human TRPV6-Y467A in complex with 2-Aminoethoxydiphenyl borate (2-APB) | Descriptor: | 2-aminoethyl diphenylborinate, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | Authors: | Singh, A.K, Saotome, K, McGoldrick, L.L, Sobolevsky, A.I. | Deposit date: | 2018-04-25 | Release date: | 2018-07-18 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.44 Å) | Cite: | Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB. Nat Commun, 9, 2018
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6D7S
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![BU of 6d7s by Molmil](/molmil-images/mine/6d7s) | |
6D7Q
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![BU of 6d7q by Molmil](/molmil-images/mine/6d7q) | Crystal Structure of Rat TRPV6*-Y466A in complex with 2-Aminoethoxydiphenyl borate (2-APB) | Descriptor: | 2-aminoethyl diphenylborinate, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, ... | Authors: | Singh, A.K, Saotome, K, McGoldrick, L.L, Sobolevsky, A.I. | Deposit date: | 2018-04-25 | Release date: | 2018-07-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.497 Å) | Cite: | Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB. Nat Commun, 9, 2018
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6D7P
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![BU of 6d7p by Molmil](/molmil-images/mine/6d7p) | Crystal Structure of Rat TRPV6*-Y466A | Descriptor: | 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | Authors: | Singh, A.K, Saotome, K, McGoldrick, L.L, Sobolevsky, A.I. | Deposit date: | 2018-04-25 | Release date: | 2018-07-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.37 Å) | Cite: | Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB. Nat Commun, 9, 2018
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6D7O
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![BU of 6d7o by Molmil](/molmil-images/mine/6d7o) | Crystal Structure of Rat TRPV6* in complex with 2-Aminoethoxydiphenyl borate (2-APB) | Descriptor: | 2-aminoethyl diphenylborinate, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, ... | Authors: | Singh, A.K, Saotome, K, McGoldrick, L.L, Sobolevsky, A.I. | Deposit date: | 2018-04-25 | Release date: | 2018-07-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB. Nat Commun, 9, 2018
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6D7L
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![BU of 6d7l by Molmil](/molmil-images/mine/6d7l) | |
6D1W
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![BU of 6d1w by Molmil](/molmil-images/mine/6d1w) | human PKD2 F604P mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | Authors: | Zheng, W, Yang, X, Bulkley, D, Chen, X.Z, Cao, E. | Deposit date: | 2018-04-12 | Release date: | 2018-06-27 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. Nat Commun, 9, 2018
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6CX0
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![BU of 6cx0 by Molmil](/molmil-images/mine/6cx0) | Structure of AtTPC1 D376A | Descriptor: | (1S,3R)-1-(3-{[4-(2-fluorophenyl)piperazin-1-yl]methyl}-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid, CALCIUM ION, Two pore calcium channel protein 1 | Authors: | Kintzer, A.F, Stroud, R.M. | Deposit date: | 2018-04-02 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.501 Å) | Cite: | Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6CV9
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![BU of 6cv9 by Molmil](/molmil-images/mine/6cv9) | |