6D7T

Cryo-EM structure of human TRPV6-Y467A in complex with 2-Aminoethoxydiphenyl borate (2-APB)

Summary for 6D7T

• Entry DOI: 10.2210/pdb6d7t/pdb
• EMDB information: 7825
• Descriptor: Transient receptor potential cation channel subfamily V member 6, 2-aminoethyl diphenylborinate, CALCIUM ION (3 entities in total)
• Functional Keywords: ion channels, transporter, calcium channel, epithelial calcium channel, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 341287.97

Authors

Singh, A.K.,Saotome, K.,McGoldrick, L.L.,Sobolevsky, A.I. (deposition date: 2018-04-25, release date: 2018-07-18, Last modification date: 2019-12-18)

• Primary citation: Singh, A.K.,Saotome, K.,McGoldrick, L.L.,Sobolevsky, A.I.; Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB.; Nat Commun, 9:2465-2465, 2018; PubMed: 29941865; DOI: 10.1038/s41467-018-04828-y

Experimental method

ELECTRON MICROSCOPY (4.44 Å)