6D7T

Cryo-EM structure of human TRPV6-Y467A in complex with 2-Aminoethoxydiphenyl borate (2-APB)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transient receptor potential cation channel subfamily V member 6	polymer	742	85076.9	4	UniProt (Q9H1D0) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520)	Homo sapiens (Human)	TrpV6,CaT-like,CaT-L,Calcium transport protein 1,CaT1,Epithelial calcium channel 2,ECaC2
2	E, H, I, J (A, B, C, D)	2-aminoethyl diphenylborinate	non-polymer		225.1	4	Chemie (FZ4)
3	F, G (A)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)

Sequence modifications

A, B, C, D: 1 - 725 (UniProt: Q9H1D0)

PDB	External Database	Details
Ala 467	Tyr 507	engineered mutation
Leu 726	-	expression tag
Val 727	-	expression tag
Pro 728	-	expression tag
Arg 729	-	expression tag
Gly 730	-	expression tag
Ser 731	-	expression tag
Ala 732	-	expression tag
Ala 733	-	expression tag
Ala 734	-	expression tag
Trp 735	-	expression tag
Ser 736	-	expression tag
His 737	-	expression tag
Pro 738	-	expression tag
Gln 739	-	expression tag
Phe 740	-	expression tag
Glu 741	-	expression tag
Lys 742	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	340307.4
Non-Polymers*	Number of molecules	6
	Total formula weight	980.5
All*	Total formula weight	341288.0

*Water molecules are not included.