6D7Q

Crystal Structure of Rat TRPV6*-Y466A in complex with 2-Aminoethoxydiphenyl borate (2-APB)

Summary for 6D7Q

• Entry DOI: 10.2210/pdb6d7q/pdb
• Descriptor: Transient receptor potential cation channel subfamily V member 6, 2-aminoethyl diphenylborinate, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, ... (4 entities in total)
• Functional Keywords: ion channels, transporter, calcium channel, epithelial calcium channel, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 1
• Total formula weight: 77520.83

Authors

Singh, A.K.,Saotome, K.,McGoldrick, L.L.,Sobolevsky, A.I. (deposition date: 2018-04-25, release date: 2018-07-18, Last modification date: 2023-10-04)

• Primary citation: Singh, A.K.,Saotome, K.,McGoldrick, L.L.,Sobolevsky, A.I.; Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB.; Nat Commun, 9:2465-2465, 2018; PubMed: 29941865; DOI: 10.1038/s41467-018-04828-y

Experimental method

X-RAY DIFFRACTION (3.497 Å)