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4KQR
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid
Descriptor: (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J.
Deposit date:2013-05-15
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
Acs Chem.Biol., 8, 2013
5OJ1
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Penicillin Binding Protein 2x (PBP2x) from S.pneumoniae in complex with Oxacillin and a tetrasaccharide
Descriptor: (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, Penicillin-binding protein 2X, SODIUM ION
Authors:Bernardo-Garcia, N, Hermoso, J.A.
Deposit date:2017-07-20
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae.
ACS Chem. Biol., 13, 2018
6SYN
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BU of 6syn by Molmil
Crystal structure of Y. pestis penicillin-binding protein 3
Descriptor: (2R,4S)-2-[(1R)-1-{[(2S)-2-carboxy-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ACETATE ION, Peptidoglycan D,D-transpeptidase FtsI
Authors:Pankov, G, Hunter, W.N, Dawson, A.
Deposit date:2019-09-30
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:The structure of penicillin-binding protein 3 from Yersinia pestis
To Be Published
4L0L
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Crystal structure of P.aeruginosa PBP3 in complex with compound 4
Descriptor: (6R,7S,10Z)-10-(2-amino-1,3-thiazol-4-yl)-1-(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)-7-formyl-13,13-dimethyl-3,9-dioxo-6-(sulfoamino)-12-oxa-2,4,8,11-tetraazatetradec-10-en-14-oic acid, Penicillin-binding protein 3
Authors:Han, S, Marr, E.S.
Deposit date:2013-05-31
Release date:2013-08-21
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Pyridone-conjugated monobactam antibiotics with gram-negative activity.
J.Med.Chem., 56, 2013
5DF8
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH CEFOPERAZONE
Descriptor: (2R,4R,5R)-2-[(1R)-1-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-2-oxoethyl]-5-methyl-1,3-thiazinane-4-carboxylic acid, CHLORIDE ION, Cell division protein, ...
Authors:Ren, J, Nettleship, J.E, Males, A, Stuart, D.I, Owens, R.J.
Deposit date:2015-08-26
Release date:2016-01-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms.
Febs Lett., 590, 2016
5DF9
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BU of 5df9 by Molmil
CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 IN COMPLEX WITH DEACYLATED PRODUCT OF CEFOPERAZONE
Descriptor: (2R,5R)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}methyl]-5-methyl-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Cell division protein, GLYCEROL, ...
Authors:Ren, J, Nettleship, J.E, Males, A, Stuart, D.I, Owens, R.J.
Deposit date:2015-08-26
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms.
Febs Lett., 590, 2016
1K25
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BU of 1k25 by Molmil
PBP2x from a Highly Penicillin-resistant Streptococcus pneumoniae Clinical Isolate
Descriptor: low-affinity PENICILLIN-BINDING PROTEIN 2X
Authors:Dessen, A, Mouz, N, Hopkins, J, Dideberg, O.
Deposit date:2001-09-26
Release date:2001-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations.
J.Biol.Chem., 276, 2001
1PYY
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BU of 1pyy by Molmil
Double mutant PBP2x T338A/M339F from Streptococcus pneumoniae strain R6 at 2.4 A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 6-O-octanoyl-beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, Penicillin-binding protein 2X, ...
Authors:Chesnel, L, Pernot, L, Lemaire, D, Champelovier, D, Croize, J, Dideberg, O, Vernet, T, Zapun, A.
Deposit date:2003-07-09
Release date:2003-09-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:The Structural Modifications Induced by the M339F Substitution in PBP2x from Streptococcus pneumoniae Further Decreases the Susceptibility to beta-Lactams of Resistant Strains
J.Biol.Chem., 278, 2003
2WAD
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PENICILLIN-BINDING PROTEIN 2B (PBP-2B) FROM STREPTOCOCCUS PNEUMONIAE (STRAIN 5204)
Descriptor: PENICILLIN-BINDING PROTEIN 2B, ZINC ION
Authors:Contreras-Martel, C, Dahout-Gonzalez, C, Dos-Santos-Martins, A, Kotnik, M, Dessen, A.
Deposit date:2009-02-05
Release date:2009-02-24
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Pbp Active Site Flexibility as the Key Mechanism for Beta-Lactam Resistance in Pneumococci
J.Mol.Biol., 387, 2009
1PMD
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BU of 1pmd by Molmil
PENICILLIN-BINDING PROTEIN 2X (PBP-2X)
Descriptor: PEPTIDOGLYCAN SYNTHESIS MULTIFUNCTIONAL ENZYME
Authors:Pares, S, Mouz, N, Dideberg, O.
Deposit date:1996-02-05
Release date:1997-02-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme.
Nat.Struct.Biol., 3, 1996
2WAF
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BU of 2waf by Molmil
PENICILLIN-BINDING PROTEIN 2B (PBP-2B) FROM STREPTOCOCCUS PNEUMONIAE (STRAIN R6)
Descriptor: CHLORIDE ION, PENICILLIN-BINDING PROTEIN 2B
Authors:Contreras-Martel, C, Dahout-Gonzalez, C, Dos-Santos-Martins, A, Kotnik, M, Dessen, A.
Deposit date:2009-02-05
Release date:2009-02-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Pbp Active Site Flexibility as the Key Mechanism for Beta-Lactam Resistance in Pneumococci
J.Mol.Biol., 387, 2009
2WAE
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BU of 2wae by Molmil
PENICILLIN-BINDING PROTEIN 2B (PBP-2B) FROM STREPTOCOCCUS PNEUMONIAE (STRAIN 5204)
Descriptor: PENICILLIN-BINDING PROTEIN 2B, ZINC ION
Authors:Contreras-Martel, C, Dahout-Gonzalez, C, Dos-Santos-Martins, A, Kotnik, M, Dessen, A.
Deposit date:2009-02-05
Release date:2009-02-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Pbp Active Site Flexibility as the Key Mechanism for Beta-Lactam Resistance in Pneumococci
J.Mol.Biol., 387, 2009
5E31
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BU of 5e31 by Molmil
2.3 Angstrom Crystal Structure of the Monomeric Form of Penicillin Binding Protein 2 Prime from Enterococcus faecium.
Descriptor: Penicillin binding protein 2 prime
Authors:Minasov, G, Wawrzak, Z, Shuvalova, L, Dubrovska, I, Flores, K, Filippova, E, Grimshaw, S, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2015-10-01
Release date:2015-10-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:2.3 Angstrom Crystal Structure of the Monomeric Form of Penicillin Binding Protein 2 Prime from Enterococcus faecium.
To Be Published
7RD0
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BU of 7rd0 by Molmil
Crystal structure of C. difficile penicillin-binding protein 3 in apo form
Descriptor: GLYCEROL, Penicillin-binding protein, ZINC ION
Authors:Sacco, M, Chen, Y.
Deposit date:2021-07-08
Release date:2022-03-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.
Nat Commun, 13, 2022
7RCW
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BU of 7rcw by Molmil
Crystal structure of C. difficile penicillin-binding protein 2 in complex with ampicillin
Descriptor: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Sacco, M, Chen, Y.
Deposit date:2021-07-08
Release date:2022-03-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.
Nat Commun, 13, 2022
7RCX
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BU of 7rcx by Molmil
Crystal structure of C. difficile penicillin-binding protein 2 in apo form
Descriptor: GLYCEROL, Penicillin-binding protein, SULFATE ION, ...
Authors:Sacco, M, Chen, Y.
Deposit date:2021-07-08
Release date:2022-03-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.
Nat Commun, 13, 2022
7RCZ
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Crystal structure of C. difficile SpoVD in complex with ampicillin
Descriptor: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Sacco, M, Chen, Y.
Deposit date:2021-07-08
Release date:2022-03-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.
Nat Commun, 13, 2022
7RCY
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BU of 7rcy by Molmil
Crystal structure of C. difficile penicillin-binding protein 2 in complex with ceftobiprole
Descriptor: (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Penicillin-binding protein, ZINC ION
Authors:Sacco, M, Chen, Y.
Deposit date:2021-07-08
Release date:2022-03-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.
Nat Commun, 13, 2022
5DVY
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BU of 5dvy by Molmil
2.95 Angstrom Crystal Structure of the Dimeric Form of Penicillin Binding Protein 2 Prime from Enterococcus faecium
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Penicillin binding protein 2 prime, SULFATE ION
Authors:Minasov, G, Wawrzak, Z, Shuvalova, L, Dubrovska, I, Flores, K, Filippova, E, Grimshaw, S, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2015-09-21
Release date:2015-10-07
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:2.95 Angstrom Crystal Structure of the Dimeric Form of Penicillin Binding Protein 2 Prime from Enterococcus faecium.
To Be Published
7JWL
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Crystal Structure of Pseudomonas aeruginosa Penicillin Binding Protein 3 (PAE-PBP3) bound to ETX0462
Descriptor: CHLORIDE ION, ETX0462 (Bound form), Peptidoglycan D,D-transpeptidase FtsI
Authors:Mayclin, S.J, Abendroth, J, Horanyi, P.S, Sylvester, M, Wu, X, Shapiro, A, Moussa, S, Durand-Reville, T.F.
Deposit date:2020-08-25
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational design of a new antibiotic class for drug-resistant infections.
Nature, 597, 2021
5DF7
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BU of 5df7 by Molmil
CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH AZLOCILLIN
Descriptor: (2R,4S)-5,5-dimethyl-2-[(1R)-2-oxo-1-{[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}ethyl]-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, Cell division protein, ...
Authors:Ren, J, Nettleship, J.E, Males, A, Stuart, D.I, Owens, R.J.
Deposit date:2015-08-26
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms.
Febs Lett., 590, 2016
1QME
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BU of 1qme by Molmil
PENICILLIN-BINDING PROTEIN 2X (PBP-2X)
Descriptor: PENICILLIN-BINDING PROTEIN 2X, SULFATE ION
Authors:Gordon, E.J, Mouz, N, Duee, E, Dideberg, O.
Deposit date:1999-09-28
Release date:2000-05-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Crystal Structure of the Penicillin-Binding Protein 2X from Streptococcus Pneumoniae and its Acyl-Enzyme Form: Implication in Drug Resistance.
J.Mol.Biol., 299, 2000
7KIS
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BU of 7kis by Molmil
Crystal structure of Pseudomonas aeruginosa PBP2 in complex with WCK 5153
Descriptor: (2S,5R)-1-formyl-N'-[(3R)-pyrrolidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, CHLORIDE ION, Peptidoglycan D,D-transpeptidase MrdA
Authors:Rajavel, M, van den Akker, F.
Deposit date:2020-10-24
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.869 Å)
Cite:Structural Characterization of Diazabicyclooctane beta-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa.
Mbio, 12, 2021
7KIV
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BU of 7kiv by Molmil
Crystal structure of Pseudomonas aeruginosa PBP3 in complex with avibactam
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Peptidoglycan D,D-transpeptidase FtsI
Authors:van den Akker, F.
Deposit date:2020-10-24
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.389 Å)
Cite:Structural Characterization of Diazabicyclooctane beta-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa.
Mbio, 12, 2021
7KIW
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Crystal structure of Pseudomonas aeruginosa PBP3 in complex with zidebactam
Descriptor: (2S,5R)-1-formyl-N'-[(3R)-piperidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, Peptidoglycan D,D-transpeptidase FtsI
Authors:van den Akker, F, Kumar, V.
Deposit date:2020-10-25
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural Characterization of Diazabicyclooctane beta-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa.
Mbio, 12, 2021

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