4CPK
Crystal structure of PBP2a double clinical mutant N146K-E150K from MRSA
Summary for 4CPK
| Entry DOI | 10.2210/pdb4cpk/pdb |
| Descriptor | Penicillin binding protein 2 prime, CADMIUM ION, CHLORIDE ION, ... (5 entities in total) |
| Functional Keywords | hydrolase, penicillin-binding protein, mrsa, allosteric site |
| Biological source | Staphylococcus aureus (strain Mu50 / ATCC 700699) |
| Total number of polymer chains | 2 |
| Total formula weight | 148742.77 |
| Authors | Otero, L.H.,Rojas-Altuve, A.,Hermoso, J.A. (deposition date: 2014-02-07, release date: 2014-09-10, Last modification date: 2023-12-20) |
| Primary citation | Fishovitz, J.,Rojas-Altuve, A.,Otero, L.H.,Dawley, M.,Carrasco-Lopez, C.,Chang, M.,Hermoso, J.A.,Mobashery, S. Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics. J.Am.Chem.Soc., 136:9814-, 2014 Cited by PubMed: 24955778DOI: 10.1021/JA5030657 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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