4CJN

Crystal structure of PBP2a from MRSA in complex with quinazolinone ligand

Summary for 4CJN

Entry DOI	10.2210/pdb4cjn/pdb
Descriptor	PENICILLIN BINDING PROTEIN 2 PRIME, CADMIUM ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	hydrolase, immune system, allosteric site
Biological source	STAPHYLOCOCCUS AUREUS SUBSP. AUREUS MU50
Total number of polymer chains	2
Total formula weight	148060.63
Authors	Bouley, R.,Otero, L.H.,Rojas-Altuve, A.,Hermoso, J.A. (deposition date: 2013-12-21, release date: 2015-02-11, Last modification date: 2023-12-20)
Primary citation	Bouley, R.,Kumarasiri, M.,Peng, Z.,Otero, L.H.,Song, W.,Suckow, M.A.,Schroeder, V.A.,Wolter, W.R.,Lastochkin, E.,Antunes, N.T.,Pi, H.,Vakulenko, S.,Hermoso, J.A.,Chang, M.,Mobashery, S. Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-Cyanostyryl)Quinazolin-4(3H)-One. J.Am.Chem.Soc., 137:1738-, 2015 Cited by PubMed: 25629446 DOI: 10.1021/JACS.5B00056 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.947 Å)

Structure validation