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2O1W
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BU of 2o1w by Molmil
Structure of N-terminal plus middle domains (N+M) of GRP94
Descriptor: Endoplasmin
Authors:Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
5TTH
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BU of 5tth by Molmil
Heterodimeric SpyCatcher/SpyTag-fused zebrafish TRAP1 in ATP/ADP-hybrid state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, C-terminal SpyCatcher fusion of wildtype zebrafish TNF receptor-associated protein 1, ...
Authors:Elnatan, D, Betegon, M, Liu, Y, Agard, D.A, Northeast Structural Genomics Consortium (NESG)
Deposit date:2016-11-03
Release date:2017-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.
Elife, 6, 2017
5TVX
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BU of 5tvx by Molmil
Crystal structure of mitochondrial Hsp90 (TRAP1) with ATP in absence of Mg, fully hydrolyzed
Descriptor: ADENOSINE-5'-DIPHOSPHATE, TNF receptor-associated protein 1
Authors:Elnatan, D, Betegon, M, Agard, D.A.
Deposit date:2016-11-10
Release date:2017-10-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.
Elife, 6, 2017
5TVU
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BU of 5tvu by Molmil
Crystal structure of mitochondrial Hsp90 (TRAP1) with ATP in absence of Mg
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, TNF receptor-associated protein 1
Authors:Elnatan, D, Betegon, M, Agard, D.A.
Deposit date:2016-11-10
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.
Elife, 6, 2017
5ULS
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BU of 5uls by Molmil
Structure of GRP94 in the active conformation
Descriptor: Endoplasmin, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Huck, J.D, Que, N.L.S, Gewirth, D.T.
Deposit date:2017-01-25
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.622 Å)
Cite:Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.
Cell Rep, 20, 2017
5TVW
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BU of 5tvw by Molmil
Crystal structure of mitochondrial Hsp90 (TRAP1) with ATP in absence of Mg, hemi-hydrolyzed
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, COBALT (II) ION, ...
Authors:Elnatan, D, Betegon, M, Agard, D.A, Northeast Structural Genomics Consortium (NESG)
Deposit date:2016-11-10
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.
Elife, 6, 2017
8FX4
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BU of 8fx4 by Molmil
GC-C-Hsp90-Cdc37 regulatory complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Guanylyl cyclase C, Heat shock protein HSP 90-beta, ...
Authors:Caveney, N.A, Garcia, K.C.
Deposit date:2023-01-23
Release date:2023-07-12
Last modified:2023-08-23
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.
Elife, 12, 2023
6XLE
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BU of 6xle by Molmil
Full-length Hsc82 in complex with two Aha1 CTD in the presence of AMP-PNP
Descriptor: ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ...
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published
6XLC
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BU of 6xlc by Molmil
Full-length Hsc82 bound to AMPPNP
Descriptor: ATP-dependent molecular chaperone HSC82, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Full-length Hsc82 bound to AMPPNP
To Be Published
6XLB
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BU of 6xlb by Molmil
Apo full-length Hsc82 in complex with Aha1
Descriptor: ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Apo full-length Hsc82 in complex with Aha1
To Be Published
6XLG
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BU of 6xlg by Molmil
Full-length Hsc82 in complex with two Aha1 CTD in the presence of ATPgammaS
Descriptor: ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ...
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.71 Å)
Cite:Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published
6XLF
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BU of 6xlf by Molmil
Full-length Hsc82 in complex with Aha1 in the presence of AMP-PNP
Descriptor: ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ...
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published
6XLH
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BU of 6xlh by Molmil
Asymmetric hydrolysis state of Hsc82 in complex with Aha1 bound with ADP and ATPgammaS
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, ...
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published
6XLD
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BU of 6xld by Molmil
Full-length Hsc82 in complex with Aha1 CTD in the presence of AMPPNP
Descriptor: ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ...
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Full-length Hsc82 in complex with Aha1 CTD in the presence of AMPPNP
To Be Published
7KCL
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BU of 7kcl by Molmil
Full-length human mitochondrial Hsp90 (TRAP1) in complex with SdhB in the presence of AMP-PNP
Descriptor: Heat shock protein 75 kDa, mitochondrial, MAGNESIUM ION, ...
Authors:Liu, Y.X, Agard, D.A.
Deposit date:2020-10-06
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates
To Be Published
7KCM
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BU of 7kcm by Molmil
Full-length human mitochondrial Hsp90 (TRAP1) in complex with SdhB in the presence of AMP-PNP
Descriptor: FE2/S2 (INORGANIC) CLUSTER, Heat shock protein 75 kDa, mitochondrial, ...
Authors:Liu, Y.X, Agard, D.A.
Deposit date:2020-10-06
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates
To Be Published
7L7J
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BU of 7l7j by Molmil
Cryo-EM structure of Hsp90:p23 closed-state complex
Descriptor: Heat shock protein HSP 90-alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Prostaglandin E synthase 3
Authors:Lee, K, Thwin, A.C, Tse, E, Gates, S.N, Southworth, D.R.
Deposit date:2020-12-28
Release date:2021-08-25
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.
Mol.Cell, 81, 2021
7L7I
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BU of 7l7i by Molmil
Cryo-EM structure of Hsp90:FKBP51:p23 closed-state complex
Descriptor: Heat shock protein HSP 90-alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Peptidyl-prolyl cis-trans isomerase FKBP5, ...
Authors:Lee, K, Thwin, A.C, Tse, E, Gates, S.N, Southworth, D.R.
Deposit date:2020-12-28
Release date:2021-08-25
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state.
Mol.Cell, 81, 2021
7KLV
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BU of 7klv by Molmil
Full-length human mitochondrial Hsp90 (TRAP1) SpyCatcher/SpyTag-SdhB heterodimer in the presence of AMP-PNP
Descriptor: Heat shock protein 75 kDa, mitochondrial, SpyCatcher, ...
Authors:Liu, Y.X, Agard, D.A.
Deposit date:2020-11-01
Release date:2021-11-03
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM analysis of human mitochondrial Hsp90 in multiple tetrameric states
To Be Published
7KLU
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BU of 7klu by Molmil
Tetrameric human mitochondrial Hsp90 (TRAP1) in the presence of AMP-PNP
Descriptor: Heat shock protein 75 kDa, mitochondrial, SpyCatcher, ...
Authors:Liu, Y.X, Agard, D.A.
Deposit date:2020-11-01
Release date:2021-11-03
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM analysis of human mitochondrial Hsp90 in multiple tetrameric states
To Be Published
7Z37
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BU of 7z37 by Molmil
Structure of the RAF1-HSP90-CDC37 complex (RHC-II)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G.
Deposit date:2022-03-01
Release date:2022-09-14
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation.
Mol.Cell, 82, 2022
7Z38
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BU of 7z38 by Molmil
Structure of the RAF1-HSP90-CDC37 complex (RHC-I)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G.
Deposit date:2022-03-01
Release date:2022-09-14
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation.
Mol.Cell, 82, 2022
7Y04
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BU of 7y04 by Molmil
Hsp90-AhR-p23 complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aryl hydrocarbon receptor, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F.
Deposit date:2022-06-03
Release date:2023-01-04
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of the cytosolic AhR complex.
Structure, 31, 2023
5FWM
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BU of 5fwm by Molmil
Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CYCLIN-DEPENDENT KINASE 4, HEAT SHOCK PROTEIN HSP 90 BETA, ...
Authors:Verba, K.A, Wang, R.Y.R, Arakawa, A, Liu, Y, Yokoyama, S, Agard, D.A.
Deposit date:2016-02-18
Release date:2016-07-06
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Atomic Structure of Hsp90-Cdc37-Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Science, 352, 2016
5FWK
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BU of 5fwk by Molmil
Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CYCLIN-DEPENDENT KINASE 4, HEAT SHOCK PROTEIN HSP 90 BETA, ...
Authors:Verba, K.A, Wang, R.Y.R, Arakawa, A, Liu, Y, Yokoyama, S, Agard, D.A.
Deposit date:2016-02-17
Release date:2016-07-06
Last modified:2019-08-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Atomic Structure of Hsp90-Cdc37-Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Science, 352, 2016

221051

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